公开(公告)号：US10070914B2

公开(公告)日：2018-09-11

申请号：US14366909

申请日：2012-12-20

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Karl H. Schoenbach ,  Richard Heller ,  James Camp ,  Stephen P. Beebe ,  Shu Xiao ,  Amy Donate

IPC: A61N1/30 ,  A61B18/12 ,  A61N1/40 ,  A61N1/32 ,  A61N5/00 ,  A61N5/02 ,  A61N5/06 ,  A61B18/18 ,  A61B18/20 ,  A61B18/24 ,  A61B18/00 ,  A61N5/067

CPC classification number: A61B18/1206 ,  A61B18/12 ,  A61B18/1815 ,  A61B18/20 ,  A61B18/24 ,  A61B2018/00613 ,  A61B2018/00761 ,  A61B2018/00767 ,  A61B2018/00791 ,  A61B2018/00994 ,  A61N1/327 ,  A61N1/403 ,  A61N5/00 ,  A61N5/025 ,  A61N5/0625 ,  A61N2005/0651 ,  A61N2005/0666 ,  A61N2005/067

Abstract: Systems and methods for treatment of a biological tissues comprising target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.

公开(公告)号：US20140364797A1

公开(公告)日：2014-12-11

申请号：US14366909

申请日：2012-12-20

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Karl H. Schoenbach ,  Richard Heller ,  James Camp ,  Stephen P. Beebe ,  Shu Xiao ,  Amy Donate

IPC: A61B18/12 ,  A61N5/02 ,  A61N5/06 ,  A61N1/32 ,  A61N5/00

CPC classification number: A61B18/1206 ,  A61B18/12 ,  A61B18/1815 ,  A61B18/20 ,  A61B18/24 ,  A61B2018/00613 ,  A61B2018/00761 ,  A61B2018/00767 ,  A61B2018/00791 ,  A61B2018/00994 ,  A61N1/327 ,  A61N1/403 ,  A61N5/00 ,  A61N5/025 ,  A61N5/0625 ,  A61N2005/0651 ,  A61N2005/0666 ,  A61N2005/067

Abstract: Systems and methods for treatment of a biological tissues comprising target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.

Abstract translation: 用于治疗包含靶组织和其他组织的生物组织的系统和方法。 所述方法包括将目标组织的温度升高到生物组织的生理温度以上至处理温度，并且使用预定义的施加在at之间的短电压脉冲序列产生延伸穿过目标组织的至少一部分的电场 至少两个电极。 在该方法中，在生成期间维持处理温度。 此外，预定义的序列被选择为使得所产生的电场的量值足以在目标组织的部分中诱导电动势，而不会使目标组织的部分的温度基本上升高到处理温度以上。

公开(公告)号：US10660693B2

公开(公告)日：2020-05-26

申请号：US16057115

申请日：2018-08-07

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Karl H. Schoenbach ,  Richard Heller ,  James Camp ,  Stephen P. Beebe ,  Shu Xiao ,  Amy Donate

IPC: A61B18/12 ,  A61N1/40 ,  A61N1/32 ,  A61N5/00 ,  A61N5/02 ,  A61N5/06 ,  A61B18/18 ,  A61B18/20 ,  A61B18/00 ,  A61N5/067 ,  A61B18/24

Abstract: Systems and methods for treatment of a biological tissues including target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.