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1.发明申请ELECTROMANIPULATION OF CELLS AND OTHER BIOLOGICALTISSUES BY PULSED ELECTRIC FIELDS AT ELEVATED TEMPERATURES 审中-公开脉冲电场在高温下的细胞和其他生物学的电化学公开(公告)号：US20140364797A1
公开(公告)日：2014-12-11
申请号：US14366909
申请日：2012-12-20
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Karl H. Schoenbach , Richard Heller , James Camp , Stephen P. Beebe , Shu Xiao , Amy Donate
CPC classification number: A61B18/1206 , A61B18/12 , A61B18/1815 , A61B18/20 , A61B18/24 , A61B2018/00613 , A61B2018/00761 , A61B2018/00767 , A61B2018/00791 , A61B2018/00994 , A61N1/327 , A61N1/403 , A61N5/00 , A61N5/025 , A61N5/0625 , A61N2005/0651 , A61N2005/0666 , A61N2005/067
Abstract: Systems and methods for treatment of a biological tissues comprising target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.
Abstract translation: 用于治疗包含靶组织和其他组织的生物组织的系统和方法。 所述方法包括将目标组织的温度升高到生物组织的生理温度以上至处理温度，并且使用预定义的施加在at之间的短电压脉冲序列产生延伸穿过目标组织的至少一部分的电场 至少两个电极。 在该方法中，在生成期间维持处理温度。 此外，预定义的序列被选择为使得所产生的电场的量值足以在目标组织的部分中诱导电动势，而不会使目标组织的部分的温度基本上升高到处理温度以上。
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公开(公告)号：US20140360862A1
公开(公告)日：2014-12-11
申请号：US14362181
申请日：2012-12-03
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Muhammad Arif Malik , Karl H. Schoenbach
CPC classification number: B01J12/002 , B01J8/0242 , B01J19/088 , B01J2219/0809 , B01J2219/0811 , B01J2219/0828 , B01J2219/083 , B01J2219/0841 , B01J2219/0849 , B01J2219/0871 , B01J2219/0875 , B01J2219/0883 , B01J2219/0888 , B01J2219/0892 , B01J2219/0894 , C01B3/342 , C01B4/00 , C01B15/01 , C01B2203/0861 , C07C37/00 , G21F9/02 , H05B6/46 , Y02E60/36
Abstract: Gas treatment systems and methods are provided. A system includes at least one device defining a space and having a gas inlet and a gas outlet. The device also includes an electrode assembly, where the electrode assembly includes a dielectric plate, at least one first electrode, at least one second electrode, and a conductive layer. The electrodes are elongate electrodes disposed on a first major surface of the dielectric plate and arranged substantially in parallel. Further, the conductive layer extends over a second major surface of the dielectric plate, is electrically coupled to the one of the electrodes, and is electrically isolated from the other electrode. The system includes a circuit configured for generating a pulsed electric field between the electrodes.
Abstract translation: 提供了气体处理系统和方法。 一种系统包括至少一个限定空间并具有气体入口和气体出口的装置。 该装置还包括电极组件，其中电极组件包括电介质板，至少一个第一电极，至少一个第二电极和导电层。 电极是设置在电介质板的第一主表面上并且基本上平行布置的细长电极。 此外，导电层在电介质板的第二主表面上延伸，电耦合到电极之一，并且与另一个电极电隔离。 该系统包括被配置为在电极之间产生脉冲电场的电路。
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公开(公告)号：US10905874B2
公开(公告)日：2021-02-02
申请号：US15922758
申请日：2018-03-15
Inventor： Richard Nuccitelli , Stephen J. Beebe , Karl H. Schoenbach
Abstract: Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin.
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公开(公告)号：US10328259B2
公开(公告)日：2019-06-25
申请号：US16014822
申请日：2018-06-21
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Shu Xiao , Andrei Pakhomov , Karl H. Schoenbach
Abstract: A system for treatment of biological tissues is provided. The system can deliver electric pulses to a targeted region within a biological tissue. The system includes an antenna assembly and a lens. The antenna assembly is configured to generate and direct electromagnetic radiation. The lens is configured to be positioned between a surface of the biological tissue and the antenna assembly. The lens can have a plurality of lossy portions. The lens can be configured to be adjustable to create a patient-specific desired electric field distribution by selective positioning of the plurality of lossy portions within the lens.
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公开(公告)号：US10070914B2
公开(公告)日：2018-09-11
申请号：US14366909
申请日：2012-12-20
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Karl H. Schoenbach , Richard Heller , James Camp , Stephen P. Beebe , Shu Xiao , Amy Donate
IPC: A61N1/30 , A61B18/12 , A61N1/40 , A61N1/32 , A61N5/00 , A61N5/02 , A61N5/06 , A61B18/18 , A61B18/20 , A61B18/24 , A61B18/00 , A61N5/067
CPC classification number: A61B18/1206 , A61B18/12 , A61B18/1815 , A61B18/20 , A61B18/24 , A61B2018/00613 , A61B2018/00761 , A61B2018/00767 , A61B2018/00791 , A61B2018/00994 , A61N1/327 , A61N1/403 , A61N5/00 , A61N5/025 , A61N5/0625 , A61N2005/0651 , A61N2005/0666 , A61N2005/067
Abstract: Systems and methods for treatment of a biological tissues comprising target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.
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Patent Agency Ranking
公开(公告)号：US09724011B2
公开(公告)日：2017-08-08
申请号：US14885023
申请日：2015-10-16
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Karl H. Schoenbach , Shu Xiao
CPC classification number: A61B5/0507 , A61B5/05 , A61B6/03 , A61B2576/00
Abstract: An imaging and recordation system is provided. The system includes a high-power, focusing antenna for illuminating biological tissue. The system further includes a power source for powering the antenna. The system further includes a data acquisition module, for recording the dielectric properties of tissues illuminated by the high-power, focusing antenna. The system illuminates the tissues using ultrashort electrical pulses.
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公开(公告)号：US10660693B2
公开(公告)日：2020-05-26
申请号：US16057115
申请日：2018-08-07
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Karl H. Schoenbach , Richard Heller , James Camp , Stephen P. Beebe , Shu Xiao , Amy Donate
IPC: A61B18/12 , A61N1/40 , A61N1/32 , A61N5/00 , A61N5/02 , A61N5/06 , A61B18/18 , A61B18/20 , A61B18/00 , A61N5/067 , A61B18/24
Abstract: Systems and methods for treatment of a biological tissues including target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.
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公开(公告)号：US10653880B2
公开(公告)日：2020-05-19
申请号：US15654625
申请日：2017-07-19
Inventor： Stephen J. Beebe , Karl H. Schoenbach
Abstract: A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an agent into a cell via known methods followed by the application of nanosecond pulse electric fields to said cell in order to facilitate entry of the agent into the nucleus of the cell. In a preferred embodiment, the present invention is directed to a method of enhancing gene expression in a cell comprising the application of nanosecond pulse electric fields to said cell. An apparatus for generating long and short pulses according to the present invention is also provided. The apparatus includes a pulse generator capable of producing a first pulse having a long duration and low voltage amplitude and a second pulse having a short duration and high voltage amplitude.
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公开(公告)号：US09943684B2
公开(公告)日：2018-04-17
申请号：US14869286
申请日：2015-09-29
Inventor： Richard Nuccitelli , Stephen J. Beebe , Karl H. Schoenbach
Abstract: Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin.
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公开(公告)号：US10363093B2
公开(公告)日：2019-07-30
申请号：US15169154
申请日：2016-05-31
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Karl H. Schoenbach , Shu Xiao
Abstract: A method of inducing local cell death in patient tissue is provided. The method includes generating first and second radiation, conveying the radiation to a focusing element, and focusing the radiation on a target with the focusing element. A system for inducing local cell death in patient tissue is also provided. The system includes a power source for generating narrowband and/or ultra-wideband radiation, and a focusing element for focusing the radiation on a target.
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