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公开(公告)号：US11951307B2
公开(公告)日：2024-04-09
申请号：US17306314
申请日：2021-05-03
Applicant: Old Dominion University Research Foundation
Inventor： Andrei G. Pakhomov , Olga N. Pakhomova , Shu Xiao
CPC classification number: A61N1/323 , A61N1/327 , C12N13/00 , A61N1/0412 , A61N1/0476 , A61N1/36
Abstract: Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.
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2.发明申请ELECTROMANIPULATION OF CELLS AND OTHER BIOLOGICALTISSUES BY PULSED ELECTRIC FIELDS AT ELEVATED TEMPERATURES 审中-公开脉冲电场在高温下的细胞和其他生物学的电化学公开(公告)号：US20140364797A1
公开(公告)日：2014-12-11
申请号：US14366909
申请日：2012-12-20
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Karl H. Schoenbach , Richard Heller , James Camp , Stephen P. Beebe , Shu Xiao , Amy Donate
CPC classification number: A61B18/1206 , A61B18/12 , A61B18/1815 , A61B18/20 , A61B18/24 , A61B2018/00613 , A61B2018/00761 , A61B2018/00767 , A61B2018/00791 , A61B2018/00994 , A61N1/327 , A61N1/403 , A61N5/00 , A61N5/025 , A61N5/0625 , A61N2005/0651 , A61N2005/0666 , A61N2005/067
Abstract: Systems and methods for treatment of a biological tissues comprising target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.
Abstract translation: 用于治疗包含靶组织和其他组织的生物组织的系统和方法。 所述方法包括将目标组织的温度升高到生物组织的生理温度以上至处理温度，并且使用预定义的施加在at之间的短电压脉冲序列产生延伸穿过目标组织的至少一部分的电场 至少两个电极。 在该方法中，在生成期间维持处理温度。 此外，预定义的序列被选择为使得所产生的电场的量值足以在目标组织的部分中诱导电动势，而不会使目标组织的部分的温度基本上升高到处理温度以上。
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公开(公告)号：US11043745B2
公开(公告)日：2021-06-22
申请号：US16273112
申请日：2019-02-11
Applicant: Old Dominion University Research Foundation
Inventor： Shu Xiao , Xianbing Zou
Abstract: Resistively loaded dielectric biconical antenna apparatuses, including systems and devices, that may be used to transmit very short electrical pulses (e.g., nanosecond, sub-nanosecond, picosecond, etc.) into tissue non-invasively at energy levels sufficient to invoke biological changes in the tissue. These resistively loaded dielectric biconical antenna apparatuses may include a resistor ring reducing internal reflection and reducing energy loss, as well as delivering longer pulses (e.g. microsecond to millisecond) to tissue.
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公开(公告)号：US10660693B2
公开(公告)日：2020-05-26
申请号：US16057115
申请日：2018-08-07
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Karl H. Schoenbach , Richard Heller , James Camp , Stephen P. Beebe , Shu Xiao , Amy Donate
IPC: A61B18/12 , A61N1/40 , A61N1/32 , A61N5/00 , A61N5/02 , A61N5/06 , A61B18/18 , A61B18/20 , A61B18/00 , A61N5/067 , A61B18/24
Abstract: Systems and methods for treatment of a biological tissues including target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.
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公开(公告)号：US11351368B2
公开(公告)日：2022-06-07
申请号：US16669419
申请日：2019-10-30
Applicant: Old Dominion University Research Foundation
Inventor： Andrei G. Pakhomov , Shu Xiao , Olga N. Pakhomova , Maura Casciola
Abstract: Methods and apparatuses (systems, devices, etc.) for treating biological tissue to evoke one or more desirable biological and/or physiological effects using pulsed electric fields in the sub-microsecond range at very low electric field strength (e.g., less than 1 kV/cm) but at high (e.g., megahertz) frequencies.
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Patent Agency Ranking
公开(公告)号：US11020590B2
公开(公告)日：2021-06-01
申请号：US16104089
申请日：2018-08-16
Applicant: Old Dominion University Research Foundation
Inventor： Andrei G. Pakhomov , Olga N. Pakhomova , Shu Xiao
Abstract: Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.
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公开(公告)号：US10328259B2
公开(公告)日：2019-06-25
申请号：US16014822
申请日：2018-06-21
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Shu Xiao , Andrei Pakhomov , Karl H. Schoenbach
Abstract: A system for treatment of biological tissues is provided. The system can deliver electric pulses to a targeted region within a biological tissue. The system includes an antenna assembly and a lens. The antenna assembly is configured to generate and direct electromagnetic radiation. The lens is configured to be positioned between a surface of the biological tissue and the antenna assembly. The lens can have a plurality of lossy portions. The lens can be configured to be adjustable to create a patient-specific desired electric field distribution by selective positioning of the plurality of lossy portions within the lens.
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公开(公告)号：US10070914B2
公开(公告)日：2018-09-11
申请号：US14366909
申请日：2012-12-20
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Karl H. Schoenbach , Richard Heller , James Camp , Stephen P. Beebe , Shu Xiao , Amy Donate
IPC: A61N1/30 , A61B18/12 , A61N1/40 , A61N1/32 , A61N5/00 , A61N5/02 , A61N5/06 , A61B18/18 , A61B18/20 , A61B18/24 , A61B18/00 , A61N5/067
CPC classification number: A61B18/1206 , A61B18/12 , A61B18/1815 , A61B18/20 , A61B18/24 , A61B2018/00613 , A61B2018/00761 , A61B2018/00767 , A61B2018/00791 , A61B2018/00994 , A61N1/327 , A61N1/403 , A61N5/00 , A61N5/025 , A61N5/0625 , A61N2005/0651 , A61N2005/0666 , A61N2005/067
Abstract: Systems and methods for treatment of a biological tissues comprising target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.
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公开(公告)号：US09724011B2
公开(公告)日：2017-08-08
申请号：US14885023
申请日：2015-10-16
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Karl H. Schoenbach , Shu Xiao
CPC classification number: A61B5/0507 , A61B5/05 , A61B6/03 , A61B2576/00
Abstract: An imaging and recordation system is provided. The system includes a high-power, focusing antenna for illuminating biological tissue. The system further includes a power source for powering the antenna. The system further includes a data acquisition module, for recording the dielectric properties of tissues illuminated by the high-power, focusing antenna. The system illuminates the tissues using ultrashort electrical pulses.
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公开(公告)号：US10363093B2
公开(公告)日：2019-07-30
申请号：US15169154
申请日：2016-05-31
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Karl H. Schoenbach , Shu Xiao
Abstract: A method of inducing local cell death in patient tissue is provided. The method includes generating first and second radiation, conveying the radiation to a focusing element, and focusing the radiation on a target with the focusing element. A system for inducing local cell death in patient tissue is also provided. The system includes a power source for generating narrowband and/or ultra-wideband radiation, and a focusing element for focusing the radiation on a target.
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