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公开(公告)号：US20210070781A1
公开(公告)日：2021-03-11
申请号：US16771567
申请日：2018-06-25
申请人： OLON S.P.A.
发明人： Federico GASSA , Lazzaro FELICIANI , Alberto MAZZA , Marco QUARONI , Mara SADA , Giorgio BERTOLINI
IPC分类号： C07F5/02
摘要： The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):
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公开(公告)号：US20190194230A1
公开(公告)日：2019-06-27
申请号：US15927264
申请日：2018-03-21
申请人： OLON S.p.A.
发明人： Federico GASSA , Lazzaro FELICIANI , Alberto MAZZA , Marco QUARONI , Mara SADA , Giorgio BERTOLINI
IPC分类号： C07F5/02 , C07C37/02 , C07C39/15 , C07C39/205 , B01J23/42 , B01J23/44 , B01J27/053 , B01J27/232
CPC分类号： C07F5/027 , B01J23/42 , B01J23/44 , B01J27/053 , B01J27/232 , C07B47/00 , C07C37/02 , C07C39/15 , C07C39/205 , C07C255/50 , C07F5/025
摘要： The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):
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公开(公告)号：US20240150282A1
公开(公告)日：2024-05-09
申请号：US18273813
申请日：2021-07-07
申请人： OLON S.P.A.
发明人： Matteo VALLI , Alberto MAZZA , Lazzaro FELICIANI , Mara SADA , Giorgio BERTOLINI
IPC分类号： C07D205/04
CPC分类号： C07D205/04
摘要： The present invention relates to a novel crystalline compound of Siponimod Hemifumarate, to processes and to intermediates for its preparation, to pharmaceutical compositions containing it and to the use in therapy.
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公开(公告)号：US20230098051A1
公开(公告)日：2023-03-30
申请号：US17783449
申请日：2020-12-10
申请人： OLON S.P.A.
IPC分类号： C07D401/06
摘要： A process for the preparation of Lasmiditan and of a synthesis intermediate of formula (II): including reacting a compound of Formula (III) wherein X and Y, each independently, represent a halogen atom, with an aqueous solution of ammonia, in presence of at least one bidentate ligand and of at least one copper-based catalyst, and optionally converting the so-obtained compound of Formula (II) into a salt and/or solvate thereof.
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公开(公告)号：US20230322658A1
公开(公告)日：2023-10-12
申请号：US18017713
申请日：2021-07-30
申请人： OLON S.P.A.
发明人： Matteo VALLI , Mara SADA , Lazzaro FELICIANI , Giorgio BERTOLINI
IPC分类号： C07C249/12 , C07C251/52 , C07C249/08
CPC分类号： C07C249/12 , C07C249/08 , C07C251/52
摘要： The present invention relates to a process for the preparation of a key intermediate and other intermediates useful for the synthesis of Siponimod, a drug used for the treatment of multiple sclerosis. Object of the invention are also said novel intermediates.
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6.发明申请公开(公告)号：US20180282339A1
公开(公告)日：2018-10-04
申请号：US15772140
申请日：2016-11-16
申请人： OLON S.P.A.
IPC分类号： C07D487/04
摘要： Subject-matter of the invention is a process for the preparation of the amorphous form of ibrutinib and a novel crystalline form.
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公开(公告)号：US20170165247A1
公开(公告)日：2017-06-15
申请号：US15327138
申请日：2015-07-17
申请人： OLON S.p.A.
IPC分类号： A61K31/4439 , A61K31/19 , A61K9/14 , C07D401/12
CPC分类号： A61K31/4439 , A61K9/14 , A61K31/19 , C07D401/12
摘要： The present invention relates to new crystalline compounds of dabigatran etexilate, namely to crystalline compounds comprising mixtures of dabigatran etexilate and an acid. The invention also relates to processes for the preparation of the new crystalline compounds, pharmaceutical compositions comprising them and their use in therapy.
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公开(公告)号：US20170158645A1
公开(公告)日：2017-06-08
申请号：US15325907
申请日：2015-07-13
申请人： OLON S.p.A.
IPC分类号： C07D239/47
CPC分类号： C07D239/47 , C07B2200/13
摘要： The present invention relates to the amorphous form of macitentan and to new crystalline forms thereof. The invention also relates to processes for the preparation of the new compounds, to the pharmaceutical compositions comprising them and to the use thereof in the therapy.
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