公开(公告)号：US10309933B2

公开(公告)日：2019-06-04

申请号：US15191750

申请日：2016-06-24

Applicant: OLYMPUS CORPORATION

Inventor： Yoshiaki Murayama

IPC: G01N29/24 ,  G01N29/44 ,  G01N29/06 ,  A61B5/00 ,  G01N29/032

Abstract: A photoacoustic microscope includes a light source, an objective lens, a light scanner, a photoacoustic wave detector, and a calculation unit. The light source emits excitation light. The objective lens focuses the excitation light within a specimen. The light scanner scans the specimen with the excitation light. The photoacoustic wave detector detects photoacoustic waves. The calculation unit uses a correlation coefficient to calculate a shift in waveform due to a change over time in photoacoustic waves between a standard position and a calculation position. The calculation unit calculates the depth from the standard position at the calculation position based on the shift.

公开(公告)号：US11209532B2

公开(公告)日：2021-12-28

申请号：US16517627

申请日：2019-07-21

Applicant: OLYMPUS CORPORATION

Inventor： Yoshiaki Murayama

IPC: G01S7/52 ,  G01S15/89

Abstract: A signal processing device according to the present invention is a signal processing device that processes data of a detected ultrasound waveform representing a temporal change in the intensity of ultrasound generated at a measurement position in a specimen and includes: a comparison unit that compares a predetermined standard ultrasound waveform and the detected ultrasound waveform at the measurement position and that calculates a degree of similarity between the predetermined standard ultrasound waveform and the detected ultrasound waveform; and a discrimination unit for discriminating whether or not the measurement position corresponds to a predetermined examination subject on the basis of the degree of similarity.

公开(公告)号：US11002708B2

公开(公告)日：2021-05-11

申请号：US15637605

申请日：2017-06-29

Applicant: OLYMPUS CORPORATION

Inventor： Ikutoshi Fukushima ,  Asuka Mukai ,  Yoshiaki Murayama

IPC: G01N29/06 ,  G02B21/02 ,  G02B21/00 ,  G01N29/22 ,  G01N29/24 ,  A61B5/00 ,  A61B8/13 ,  G10K11/30

Abstract: A photoacoustic microscope objective lens unit includes: an objective lens which irradiates a sample with excitation light L; a photoacoustic wave detection unit which detects a photoacoustic wave U generated from the sample; and a photoacoustic wave guide system. The photoacoustic wave guide system includes: a photoacoustic wave separation member; and an acoustic lens that is disposed between the photoacoustic wave separation member and the sample and has a focus position that substantially matches with a focus position of the objective lens. The acoustic lens is obtained by cementing a main acoustic lens and a correction acoustic lens to each other. The main acoustic lens and the correction acoustic lens satisfy predetermined Conditional Expressions.

公开(公告)号：US10429353B2

公开(公告)日：2019-10-01

申请号：US15603857

申请日：2017-05-24

Applicant: OLYMPUS CORPORATION

Inventor： Yoshiaki Murayama

IPC: G01N29/24 ,  G02B21/00 ,  G02B21/36 ,  G01N29/44 ,  G02B21/06 ,  G01N29/06 ,  G01N29/11 ,  G01N29/48 ,  G01N21/17

Abstract: A photoacoustic microscope includes: a light source which generates pulse light; a focusing optical system which focuses the pulse light emitted from the light source and irradiate a sample with the focused pulse light; a photoacoustic signal detection unit which detects an acoustic signal generated from the sample through irradiation of the pulse light; an image signal formation unit which forms an image signal of the sample based on the acoustic signal; an information unit having information representing a relation between intensity of the pulse light entering the sample and intensity of the acoustic signal generated from the sample; and a pulse light intensity changing unit which changes intensity of the pulse light from the light source based on the information.