公开(公告)号：US20200297531A1

公开(公告)日：2020-09-24

申请号：US16861472

申请日：2020-04-29

Applicant: ORBIT BIOMEDICAL LIMITED

Inventor： Daniel W. Price ,  Brendan J. Oberkircher ,  James G. Lee ,  Clinton Denlinger ,  Daniel J. Prenger ,  Geoffrey King ,  Scott Uhland ,  Mark C. Tsai ,  Michael F. Keane ,  Isaac J. Khan ,  Benjamin L. Ko ,  Thomas E. Meyer ,  Denis P. Turner

IPC: A61F9/00 ,  A61M25/02 ,  A61B50/30 ,  A61B46/23

Abstract: An apparatus includes a pad assembly, an injector assembly, an injector driver, and a fluid source. The pad assembly is sized and configured to be placed on a forehead of a patient. The injector assembly includes a body, a flexible cannula, and a needle. The body is configured to be removably secured to the pad assembly. The cannula is sized to be inserted through an incision in an eye of a patient. The needle is slidably disposed in the cannula. The injector driver is operable to drive the needle longitudinally relative to the flexible cannula. The fluid source assembly is in fluid communication with the needle.

公开(公告)号：US10806629B2

公开(公告)日：2020-10-20

申请号：US15609457

申请日：2017-05-31

Applicant: ORBIT BIOMEDICAL LIMITED

Inventor： Daniel W. Price ,  Brendan J. Oberkircher ,  James G. Lee ,  Clinton Denlinger ,  Daniel J. Prenger ,  Geoffrey King ,  Scott Uhland ,  Mark C. Tsai ,  Michael F. Keane ,  Isaac J. Khan ,  Benjamin L. Ko ,  Thomas E. Meyer ,  Denis P. Turner

IPC: A61F9/00 ,  A61M25/02 ,  A61B50/30 ,  A61B46/23

Abstract: An apparatus includes a pad assembly, an injector assembly, an injector driver, and a fluid source. The pad assembly is sized and configured to be placed on a forehead of a patient. The injector assembly includes a body, a flexible cannula, and a needle. The body is configured to be removably secured to the pad assembly. The cannula is sized to be inserted through an incision in an eye of a patient. The needle is slidably disposed in the cannula. The injector driver is operable to drive the needle longitudinally relative to the flexible cannula. The fluid source assembly is in fluid communication with the needle.

公开(公告)号：US10478553B2

公开(公告)日：2019-11-19

申请号：US15438918

申请日：2017-02-22

Applicant: ORBIT BIOMEDICAL LIMITED

Inventor： Thomas E. Meyer ,  Benjamin L. Ko ,  Isaac J. Khan ,  Daniel W. Price ,  Brendan J. Oberkircher ,  Michael F. Keane

IPC: A61M5/158 ,  A61F9/00 ,  A61M5/168 ,  A61M5/32

Abstract: An apparatus includes a body, a cannula, and a needle. The cannula is flexible and extends distally from the body. The needle is slidably disposed in the cannula. The needle includes a sharp distal tip and a curved portion. The needle is configured to translate relative to the cannula between a proximal position and a distal position. The distal tip is configured to be positioned inside the cannula when the needle is in the proximal position. The distal tip is configured to be positioned outside the cannula when the needle is in the distal position. The needle is resiliently biased to extend along a curve through the curved portion.

公开(公告)号：US20190142635A1

公开(公告)日：2019-05-16

申请号：US16184221

申请日：2018-11-08

Applicant: Orbit Biomedical Limited

Inventor： Brendan J. Oberkircher ,  Daniel W. Price ,  Michael F. Keane ,  Saeed Sokhanvar ,  Daniel J. Yasevac ,  Michel G. Bruehwiler ,  Leah R. Soffer ,  Isaac J. Khan ,  Benjamin L. Ko ,  Christopher D. Riemann ,  Nathan D. Grubbs

IPC: A61F9/00 ,  A61M5/158

Abstract: An apparatus for delivering therapeutic agent to an eye comprises a body, a cannula, a hollow needle, and an actuation assembly. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis that is obliquely oriented relative to the longitudinal axis of the cannula. The cannula may be inserted through a sclerotomy incision to position a distal end of the cannula at a posterior region of the eye, between the choroid and sclera. The needle may be advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer, adjacent to the area of geographic atrophy.

公开(公告)号：US20190142634A1

公开(公告)日：2019-05-16

申请号：US16184212

申请日：2018-11-08

Applicant: Orbit Biomedical Limited

Inventor： Brendan J. Oberkircher ,  Daniel W. Price ,  Michael F. Keane ,  Saeed Sokhanvar ,  Daniel J. Yasevac ,  Michel G. Bruehwiler ,  Leah R. Soffer ,  Isaac J. Khan ,  Benjamin L. Ko ,  Christopher D. Riemann ,  Nathan D. Grubbs

IPC: A61F9/00 ,  A61M5/158

Abstract: An apparatus for delivering therapeutic agent to an eye comprises a body, a cannula, a hollow needle, and an actuation assembly. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis that is obliquely oriented relative to the longitudinal axis of the cannula. The cannula may be inserted through a sclerotomy incision to position a distal end of the cannula at a posterior region of the eye, between the choroid and sclera. The needle may be advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer, adjacent to the area of geographic atrophy.

公开(公告)号：US20200222232A1

公开(公告)日：2020-07-16

申请号：US16832102

申请日：2020-03-27

Applicant: ORBIT BIOMEDICAL LIMITED

Inventor： Joseph H. Contiliano ,  Thomas E. Meyer ,  Daniel J. Abbott ,  Michael F. Keane ,  Allen C. Ho ,  Mark C. Tsai ,  Isaac J. Khan

IPC: A61F9/00 ,  A61M25/06

Abstract: An apparatus has a first fluid conduit, a second fluid conduit, a connector member, an first tubular member, a second tubular member, and an inner cannula. The connector member has first and second passageways in which the first and second fluid conduits are positioned, respectively. A portion of the second tubular member is positioned within the lumen of the first tubular member. A proximal portion of the inner cannula is fixedly secured within the lumen of the first tubular member. The inner cannula lumen is in fluid communication with the first and second fluid conduits via the lumen of the first tubular member and the lumen of the second tubular member. The inner cannula may be inserted into the subretinal space of a human eye to deliver a leading bleb of fluid and then deliver a therapeutic agent, without having to withdraw the inner cannula from the subretinal space between the acts of delivering the leading bleb delivering the therapeutic agent.

公开(公告)号：US20200078514A1

公开(公告)日：2020-03-12

申请号：US16599206

申请日：2019-10-11

Applicant: Orbit Biomedical Limited

Inventor： Thomas E. Meyer ,  Benjamin L. Ko ,  Isaac J. Khan ,  Daniel W. Price ,  Brendan J. Oberkircher ,  Michael F. Keane

IPC: A61M5/158 ,  A61M5/168 ,  A61F9/00

Abstract: An apparatus includes a body, a cannula, and a needle. The cannula is flexible and extends distally from the body. The needle is slidably disposed in the cannula. The needle includes a sharp distal tip and a curved portion. The needle is configured to translate relative to the cannula between a proximal position and a distal position. The distal tip is configured to be positioned inside the cannula when the needle is in the proximal position. The distal tip is configured to be positioned outside the cannula when the needle is in the distal position. The needle is resiliently biased to extend along a curve through the curved portion.

公开(公告)号：US20190183674A1

公开(公告)日：2019-06-20

申请号：US16284185

申请日：2019-02-25

Applicant: ORBIT BIOMEDICAL LIMITED

Inventor： Mark C. Tsai ,  Brian M. Gatton, JR. ,  Michael F. Keane ,  Isaac J. Khan ,  Brendan J. Oberkircher ,  Daniel W. Price

IPC: A61F9/00 ,  A61M5/315 ,  A61M5/31 ,  A61M5/20

CPC classification number: A61F9/0008 ,  A61M5/2053 ,  A61M5/3137 ,  A61M5/31501 ,  A61M5/31505 ,  A61M5/3158 ,  A61M5/31595 ,  A61M2005/2086 ,  A61M2005/31508 ,  A61M2005/3154 ,  A61M2039/1077

Abstract: A system for storing and delivering a predetermined amount of fluid includes a syringe including a barrel, a flange disposed at the proximal end of the barrel, and a plunger assembly configured to be received in the lumen of the barrel. The plunger assembly includes a piston and a plunger rod. The plunger rod is removably couplable to the piston at the distal end of the plunger rod and includes a thumb press flange at the proximal end of the plunger rod. The system further includes a stop feature that is removably couplable to the syringe or the plunger assembly. The stop feature is configured to arrest distal advancement of the plunger assembly relative to the syringe when the plunger assembly reaches a predetermined position relative to the syringe. The stop thus ensures that a predetermined amount of fluid remains in the barrel.

公开(公告)号：US10258502B2

公开(公告)日：2019-04-16

申请号：US14843350

申请日：2015-09-02

Applicant: ORBIT BIOMEDICAL LIMITED

Inventor： Mark C. Tsai ,  Brian M. Gatton, Jr. ,  Michael F. Keane ,  Isaac J. Khan ,  Brendan J. Oberkircher ,  Daniel W. Price

IPC: A61J1/06 ,  A61M5/20 ,  A61M5/315 ,  A61F9/00 ,  A61M5/31 ,  A61M39/10

Abstract: A system for storing and delivering a predetermined amount of fluid includes a syringe including a barrel, a flange disposed at the proximal end of the barrel, and a plunger assembly configured to be received in the lumen of the barrel. The plunger assembly includes a piston and a plunger rod. The plunger rod is removably couplable to the piston at the distal end of the plunger rod and includes a thumb press flange at the proximal end of the plunger rod. The system further includes a stop feature that is removably couplable to the syringe or the plunger assembly. The stop feature is configured to arrest distal advancement of the plunger assembly relative to the syringe when the plunger assembly reaches a predetermined position relative to the syringe. The stop thus ensures that a predetermined amount of fluid remains in the barrel.

公开(公告)号：US10226379B2

公开(公告)日：2019-03-12

申请号：US14619256

申请日：2015-02-11

Applicant: ORBIT BIOMEDICAL LIMITED

Inventor： Brendan J. Oberkircher ,  Daniel W. Price ,  Michael F. Keane ,  Saeed Sokhanvar ,  Daniel J. Yasevac ,  Michel G. Bruehwiler ,  Leah R. Soffer ,  Isaac J. Khan ,  Benjamin L. Ko ,  Christopher D. Riemann ,  Nathan D. Grubbs

IPC: A61F9/00 ,  A61M5/158

Abstract: An apparatus for delivering therapeutic agent to an eye includes a body, a cannula, a hollow needle, and an actuation assembly. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis that is obliquely oriented relative to the longitudinal axis of the cannula. The cannula may be inserted through a sclerotomy incision to position a distal end of the cannula at a posterior region of the eye, between the choroid and sclera. The needle may be advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer, adjacent to the area of geographic atrophy.