公开(公告)号：US10695420B2

公开(公告)日：2020-06-30

申请号：US15528502

申请日：2015-11-20

Applicant: ANGES, INC. ,  OSAKA UNIVERSITY ,  DS PHARMA ANIMAL HEALTH CO., LTD.

Inventor： Hironori Nakagami ,  Ryuichi Morishita ,  Hiroshi Koriyama ,  Hideki Tomioka ,  Kenji Naohara

IPC: A61K39/00 ,  A61K39/29 ,  C12N7/00

Abstract: The present invention provides a combination preparation for inducing a specific immune response to an antigenic peptide, which contains (I) the antigenic peptide, and (II) an expression vector encoding a chimeric hepatitis B virus core antigen polypeptide, into which the antigenic peptide has been inserted or added, wherein said antigenic peptide is inserted in a region of amino acid residues 74-87 or 130-138 of the hepatitis B virus core antigen polypeptide, or added to the N-terminal or C-terminal of the hepatitis B virus core antigen polypeptide, wherein the antigenic peptide of (I) and the expression vector of (II) are substantially simultaneously administered to a subject.

公开(公告)号：US10233215B2

公开(公告)日：2019-03-19

申请号：US16134153

申请日：2018-09-18

Applicant: OSAKA UNIVERSITY

Inventor： Hironori Nakagami ,  Ryuichi Morishita ,  Hiroshi Koriyama ,  Akiko Tenma

IPC: A61K39/39 ,  C07K7/08 ,  A61K8/64 ,  A61Q7/00 ,  A61K38/00 ,  A61K39/00

Abstract: The invention provides a peptide and an immunostimulant or hair grower containing the peptide as an active ingredient, as well as a method for hair growth or regrowth promotion by administering an effective amount of the peptide to a mammal. The peptide has 23 or less amino acids and includes the amino acid sequence LHRLKRLRKRL (SEQ ID NO: 1), preferably the amino acid sequence LHRLKRLRKRLK (SEQ ID NO: 9).

公开(公告)号：US10112978B2

公开(公告)日：2018-10-30

申请号：US15514310

申请日：2015-09-25

Applicant: OSAKA UNIVERSITY

Inventor： Hironori Nakagami ,  Ryuichi Morishita ,  Hiroshi Koriyama ,  Akiko Tenma

IPC: A61K39/39 ,  C07K7/08 ,  A61K8/64 ,  A61Q7/00 ,  A61K38/00 ,  A61K39/00

Abstract: An object of the present invention is to provide a novel peptide and a novel immunostimulant or hair grower containing the peptide as an active ingredient. The present invention provides a peptide of 23 or less amino acids comprising the amino acid sequence LHRLKRLRKRL (SEQ ID NO: 1), preferably the amino acid sequence LHRLKRLRKRLK (SEQ ID NO: 9), and also provides an immunostimulant containing the peptide, a vaccine adjuvant containing the peptide, a vaccine composition containing the peptide, and a hair grower containing the peptide.

公开(公告)号：US11819537B2

公开(公告)日：2023-11-21

申请号：US16345028

申请日：2017-11-07

Applicant: Osaka University

Inventor： Munehisa Shimamura ,  Hironori Nakagami ,  Yuka Ikeda ,  Ryuichi Morishita ,  Hiroshi Koriyama

IPC: A61P29/00 ,  A61K38/19 ,  A61P17/06 ,  A61K9/06 ,  A61K38/08 ,  A61P17/00

CPC classification number: A61K38/191 ,  A61K9/06 ,  A61K38/08 ,  A61P17/00 ,  A61P17/06

Abstract: The present invention provides a preventive or therapeutic method for an inflammatory skin disease, such as psoriasis, the method comprising administering an oligopeptide as an active ingredient. More specifically, the invention provides a preventive or therapeutic method for an inflammatory skin disease, the method comprising administering an oligopeptide consisting of an amino acid sequence containing a DE loop sequence of RANKL protein and a β-strand D sequence of RANKL protein placed adjacent to the N-terminal side of the DE loop sequence.

公开(公告)号：US11421025B2

公开(公告)日：2022-08-23

申请号：US15108415

申请日：2014-12-26

Applicant: OSAKA UNIVERSITY

Inventor： Hiroshi Koriyama ,  Hironori Nakagami ,  Ryuichi Morishita

IPC: A61K39/00 ,  C07K16/24

Abstract: The present invention provides a vaccine against IL-17A, which uses, as an immunogen, a polypeptide containing the amino acid sequence shown in SEQ ID NO: 1, or an amino acid sequence derived from a non-human mammal, which corresponds to SEQ ID NO: 1, a prophylactic or therapeutic agent containing the vaccine for diseases involving IL-17A as an aggravation factor, and the like.

公开(公告)号：US20190002505A1

公开(公告)日：2019-01-03

申请号：US16134153

申请日：2018-09-18

Applicant: OSAKA UNIVERSITY

Inventor： Hironori Nakagami ,  Ryuichi Morishita ,  Hiroshi Koriyama ,  Akiko Tenma

IPC: C07K7/08 ,  A61Q7/00 ,  A61K39/39 ,  A61K8/64 ,  A61K38/00 ,  A61K39/00

Abstract: The invention provides a peptide and an immunostimulant or hair grower containing the peptide as an active ingredient, as well as a method for hair growth or regrowth promotion by administering an effective amount of the peptide to a mammal. The peptide has 23 or less amino acids and includes the amino acid sequence LHRLKRLRKRL (SEQ ID NO: 1), preferably the amino acid sequence LHRLKRLRKRLK (SEQ ID NO: 9).