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公开(公告)号：US11421025B2
公开(公告)日：2022-08-23
申请号：US15108415
申请日：2014-12-26
Applicant: OSAKA UNIVERSITY
Inventor： Hiroshi Koriyama , Hironori Nakagami , Ryuichi Morishita
Abstract: The present invention provides a vaccine against IL-17A, which uses, as an immunogen, a polypeptide containing the amino acid sequence shown in SEQ ID NO: 1, or an amino acid sequence derived from a non-human mammal, which corresponds to SEQ ID NO: 1, a prophylactic or therapeutic agent containing the vaccine for diseases involving IL-17A as an aggravation factor, and the like.
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公开(公告)号：US20190002505A1
公开(公告)日：2019-01-03
申请号：US16134153
申请日：2018-09-18
Applicant: OSAKA UNIVERSITY
Inventor： Hironori Nakagami , Ryuichi Morishita , Hiroshi Koriyama , Akiko Tenma
Abstract: The invention provides a peptide and an immunostimulant or hair grower containing the peptide as an active ingredient, as well as a method for hair growth or regrowth promotion by administering an effective amount of the peptide to a mammal. The peptide has 23 or less amino acids and includes the amino acid sequence LHRLKRLRKRL (SEQ ID NO: 1), preferably the amino acid sequence LHRLKRLRKRLK (SEQ ID NO: 9).
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公开(公告)号：US11819537B2
公开(公告)日：2023-11-21
申请号：US16345028
申请日：2017-11-07
Applicant: Osaka University
Inventor： Munehisa Shimamura , Hironori Nakagami , Yuka Ikeda , Ryuichi Morishita , Hiroshi Koriyama
CPC classification number: A61K38/191 , A61K9/06 , A61K38/08 , A61P17/00 , A61P17/06
Abstract: The present invention provides a preventive or therapeutic method for an inflammatory skin disease, such as psoriasis, the method comprising administering an oligopeptide as an active ingredient. More specifically, the invention provides a preventive or therapeutic method for an inflammatory skin disease, the method comprising administering an oligopeptide consisting of an amino acid sequence containing a DE loop sequence of RANKL protein and a β-strand D sequence of RANKL protein placed adjacent to the N-terminal side of the DE loop sequence.
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公开(公告)号：US20180110713A1
公开(公告)日：2018-04-26
申请号：US15834889
申请日：2017-12-07
Applicant: Osaka University
Inventor： Hironori Nakagami , Ryuichi Morishita , Hideki Tomioka , Akiko Tenma
CPC classification number: A61K8/64 , A23L33/18 , A61K38/10 , A61K2800/78 , A61Q19/08 , C07K7/06 , C07K7/08
Abstract: An object of the present invention to discover a short peptide having an anti-aging effect and to provide a novel anti-aging agent comprising the peptide as an active ingredient. The inventors have discovered that a peptide consisting of an amino acid sequence ELKLIFLHRLKRLRKRLKRK (SEQ ID NO: 1) or a partial sequence thereof and having one or more effects selected from the group consisting of promoting fibroblast growth, promoting hyaluronic acid production and contracting a collagen gel, or a derivative or salt of the peptide is useful as an active ingredient of an anti-aging agent.
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公开(公告)号：US12070498B2
公开(公告)日：2024-08-27
申请号：US17200552
申请日：2021-03-12
Applicant: OSAKA UNIVERSITY , FUNPEP CO., LTD.
Inventor： Hironori Nakagami , Ryuichi Morishita , Akiko Tenma
IPC: A61K39/395 , A61K39/00 , A61K39/39 , A61P37/04
CPC classification number: A61K39/39 , A61K39/00 , A61K39/00114 , A61K39/39533 , A61P37/04 , A61K2039/55527
Abstract: The present invention provides a vaccine containing a complex of a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and an epitope of a disease-causing biological protein such as DPP4, IL-17A, IgE, S100A9 or PCSK9, which vaccine uses a less antigenic carrier protein and is capable of inducing antibody production to serve as an effective vaccine.
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Patent Agency Ranking
公开(公告)号：US11020464B2
公开(公告)日：2021-06-01
申请号：US16486768
申请日：2018-02-20
Applicant: OSAKA UNIVERSITY , FUNPEP CO., LTD.
Inventor： Munehisa Shimamura , Tomohiro Kawano , Hironori Nakagami , Ryuichi Morishita , Hideki Mochizuki , Akiko Tenma , Takako Ehara
Abstract: Provided is an immunogenic composition comprising an antigenic peptide capable of inducing production of a neutralizing antibody against S100A9 and a carrier protein. The immunogenic composition can be used as a highly safe antithrombotic vaccine having antithrombotic effect without a long-term bleeding risk and is useful for the prevention of a disease associated with thrombus formation in which platelet aggregation is involved, particularly for the prevention of recurrent ischemic stroke.
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公开(公告)号：US20180147259A1
公开(公告)日：2018-05-31
申请号：US15575211
申请日：2016-05-16
Applicant: Osaka University
Inventor： Munehisa Shimamura , Hironori Nakagami , Hitomi Kurinami , Ryuichi Morishita
Abstract: Provided is an oligopeptide having preventive and therapeutic effects on infarction diseases. The oligopeptide contains a DE loop sequence of RANKL protein, and has inhibitory activity on proinflammatory cytokine secretion from cells.
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公开(公告)号：US20160101032A1
公开(公告)日：2016-04-14
申请号：US14780122
申请日：2014-03-27
Applicant: OSAKA UNIVERSITY
Inventor： Hironori Nakagami , Ryuichi Morishita , Hideki Tomioka , Akiko Tenma
CPC classification number: A61K8/64 , A23L33/18 , A61K38/10 , A61K2800/78 , A61Q19/08 , C07K7/06 , C07K7/08
Abstract: An object of the present invention to discover a short peptide having an anti-aging effect and to provide a novel anti-aging agent comprising the peptide as an active ingredient. The inventors have discovered that a peptide consisting of an amino acid sequence ELKLIFLHRLKRLRKRLKRK (SEQ ID NO: 1) or a partial sequence thereof and having one or more effects selected from the group consisting of promoting fibroblast growth, promoting hyaluronic acid production and contracting a collagen gel, or a derivative or salt of the peptide is useful as an active ingredient of an anti-aging agent.
Abstract translation: 本发明的目的是发现具有抗衰老作用的短肽，并提供包含该肽作为活性成分的新型抗衰老剂。 本发明人已经发现，由氨基酸序列ELKLIFLHRLKRLRKRLKRK（SEQ ID NO：1）或其部分序列组成的肽具有选自促进成纤维细胞生长，促进透明质酸产生和收缩胶原的一种或多种作用 凝胶或肽的衍生物或盐可用作抗老化剂的活性成分。
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公开(公告)号：US10543261B2
公开(公告)日：2020-01-28
申请号：US14424937
申请日：2013-08-28
Applicant: OSAKA UNIVERSITY , ANGES, INC.
Inventor： Hironori Nakagami , Mariko Kyutoku , Ryuichi Morishita , Hideki Tomioka
Abstract: The present invention provides a therapeutic or prophylactic agent for cancer, containing an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of VEGF and/or a specific epitope of angiopoietin-2, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.
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公开(公告)号：US10517926B2
公开(公告)日：2019-12-31
申请号：US15575211
申请日：2016-05-16
Applicant: Osaka University
Inventor： Munehisa Shimamura , Hironori Nakagami , Hitomi Kurinami , Ryuichi Morishita
Abstract: Provided is an oligopeptide having preventive and therapeutic effects on infarction diseases. The oligopeptide contains a DE loop sequence of RANKL protein, and has inhibitory activity on proinflammatory cytokine secretion from cells.
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