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公开(公告)号：US20190128888A1
公开(公告)日：2019-05-02
申请号：US16095340
申请日：2017-04-21
Applicant: OSAKA UNIVERSITY , TOKYO INSTITUTE OF TECHNOLOGY , National University Corporation Nagoya University , NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
Inventor： Makusu TSUTSUI , Kazumichi YOKOTA , Masateru TANIGUCHI , Tomoji KAWAI , Mina OKOCHI , Masayoshi TANAKA , Yoshinobu BABA , Noritada KAJI , Takao YASUI , Yuji MIYAHARA , Yukichi HORIGUCHI
IPC: G01N33/569 , G01N33/566 , C12Q1/04 , C12Q1/68 , C07K7/08 , C07K7/06 , C12M1/26
Abstract: A device for biological material detection includes a substrate; a through-hole through which a biological material to be tested passes, the through-hole being formed in the substrate; a molecule that interacts with the biological material to be tested passing through, the molecule being formed in the through-hole; a first chamber member that forms, with at least the surface including the through-hole on one surface side of the substrate, a first chamber to be filled with electrolyte; and a second chamber member that forms, with at least the surface including the through-hole on the other surface side of the substrate, a second chamber to be filled with electrolyte. The biological material to be tested is identified by the waveform of the ion current (passage time, shape, etc.) when the biological material to be tested passes through the through-hole.
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公开(公告)号：US20240230505A9
公开(公告)日：2024-07-11
申请号：US18547681
申请日：2022-02-08
Applicant: OSAKA UNIVERSITY
Inventor： Makusu TSUTSUI , Shohei KISHIMOTO , Masateru TANIGUCHI
IPC: G01N15/12
CPC classification number: G01N15/12
Abstract: An object is to provide a device that can measure a moving time (velocity) of a single particle with high accuracy, and an ion current measuring apparatus and a zeta potential measuring apparatus with the device, and an ion current measuring method and a zeta potential measuring method. The object can be achieved by a device used for measurement of ion current, the device including: a substrate; and a channel formed in the substrate. The channel includes a sample liquid supply channel, a sample collection channel, and constricted channel formed between the sample liquid supply channel and the sample collection channel. The constricted channel includes three or more constricted parts each formed with a protrusion part, the three or more constricted parts are formed substantially straight in a direction from the sample liquid supply channel to the sample collection channel, and when the width of each of the constricted parts is defined as 1, the spacing between adjacent constricted parts is 0.5 to 3.
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公开(公告)号：US20210285911A1
公开(公告)日：2021-09-16
申请号：US17258662
申请日：2019-07-18
Applicant: OSAKA UNIVERSITY
Inventor： Kohji NISHIDA , Noriyasu HASHIDA , Masateru TANIGUCHI , Makusu TSUTSUI
IPC: G01N27/327 , G01N27/447 , G01N33/569
Abstract: Provided are a virus measuring method, a virus measuring device, a virus determining program, a stress determining method, and a stress determining device. A virus measuring method includes a contact step of bringing a liquid specimen containing a body fluid of a subject and an electrolytic solution into contact with each other via a through-hole portion formed in a separating wall, a current measuring step of applying a voltage to the liquid specimen and the electrolytic solution with respect to the through-hole portion and obtaining a waveform of an ionic current flowing through the through-hole portion, and a virus determining step of determining the kind of a virus contained in the body fluid on the basis of the waveform. In the virus determining step, the kind of the virus is determined by comparing the waveform with waveform information that corresponds to a known virus and is obtained beforehand.
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Patent Agency Ranking
4.发明申请公开(公告)号：US20200251184A1
公开(公告)日：2020-08-06
申请号：US16470140
申请日：2017-12-12
Applicant: Osaka University
Inventor： Takashi WASHIO , Tomoji KAWAI , Masateru TANIGUCHI , Makusu TSUTSUI , Kazumichi YOKOTA , Akira ISHI , Takeshi YOSHIDA
IPC: G16B40/10 , G06K9/62 , G06N20/10 , G06F17/18 , G01N27/327 , G01N33/487
Abstract: The present invention provides a classification analysis method, a classification analysis device, and a storage medium for classification analysis, which enable, with high accuracy, the classification analysis of particulate or molecular analytes. As a means for solving the problem, a data group of particle-passage detection signals is based which are detected by a nanopore device 8 in accordance with passage of subject particles through a through-hole 12. A feature value is obtained in advance which indicates the feature of the waveform of the pulse signals corresponding to the passage of the predetermined analyte and the feature value obtained in advance is set as the learning data for the machine learning. The feature value obtained from the pulse signals of said analyzed data is set as a variable and the classification analysis on the predetermined analytes in the analyzed data can be performed by executing a classification analysis program due to the machine learning.
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5.发明申请公开(公告)号：US20190257787A1
公开(公告)日：2019-08-22
申请号：US16065633
申请日：2016-12-19
Applicant: Osaka University
Inventor： Takashi WASHIO , Tomoji KAWAI , Masateru TANIGUCHI , Makusu TSUTSUI , Kazumichi YOKOTA , Akira ISHI , Takeshi YOSHIDA
IPC: G01N27/447 , G01N33/487
Abstract: The present invention provides a number analyzing method, a number analyzing device, and a storage medium for number analysis, which enable, with high accuracy, analysis of the number or number distribution of particulate or molecular analytes according to the kinds of the analytes. A computer control program is executed on the basis of a data group of particle-passage detection signals which are detected by a nanopore device (8) in accordance with passage of subject particles through a through-hole (12). Also, a particle type distribution estimating program, which is a number deriving means, is executed, to estimate probability density on the basis of a data group based on feature values indicating feature of the waveforms of pulse signals which correspond to the passage of particles and which are obtained as the particle-passage detection signals. Thus, the number of particles can be derived for each particle type.
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公开(公告)号：US20240133790A1
公开(公告)日：2024-04-25
申请号：US18547681
申请日：2022-02-08
Applicant: OSAKA UNIVERSITY
Inventor： Makusu TSUTSUI , Shohei KISHIMOTO , Masateru TANIGUCHI
IPC: G01N15/12
CPC classification number: G01N15/12
Abstract: An object is to provide a device that can measure a moving time (velocity) of a single particle with high accuracy, and an ion current measuring apparatus and a zeta potential measuring apparatus with the device, and an ion current measuring method and a zeta potential measuring method. The object can be achieved by a device used for measurement of ion current, the device including: a substrate; and a channel formed in the substrate. The channel includes a sample liquid supply channel, a sample collection channel, and constricted channel formed between the sample liquid supply channel and the sample collection channel. The constricted channel includes three or more constricted parts each formed with a protrusion part, the three or more constricted parts are formed substantially straight in a direction from the sample liquid supply channel to the sample collection channel, and when the width of each of the constricted parts is defined as 1, the spacing between adjacent constricted parts is 0.5 to 3.
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公开(公告)号：US20200070169A1
公开(公告)日：2020-03-05
申请号：US16614707
申请日：2018-05-09
Applicant: OSAKA UNIVERSITY
Inventor： Wataru TONOMURA , Makusu TSUTSUI , Kazumichi YOKOTA , Akihide ARIMA , Masateru TANIGUCHI , Tomoji KAWAI
Abstract: Provided is a channel device that is capable of increasing the concentration of fine particles in a liquid only by use of fluid-dynamic flows without relying on electrostatic interactions. A channel device (1) in accordance with an embodiment of the present invention includes: a main channel (11) configured to allow a liquid containing fine particles to flow therethrough; a chamber (15) that is provided at an end of the main channel (11) and that is configured to store target fine particles which have increased in concentration; and a side channel (12) that is connected to a side face of the main channel (11) and that is configured to allow unwanted liquid to drain therethrough, wherein at least one of a height and a width of the side channel (12) is smaller than a particle size of the fine particles.
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公开(公告)号：US20140374255A1
公开(公告)日：2014-12-25
申请号：US14484305
申请日：2014-09-12
Applicant: KABUSHIKI KAISHA TOSHIBA , OSAKA UNIVERSITY
Inventor： Sadato HONGO , Tomoji KAWAI , Makusu TSUTSUI , Masateru TANIGUCHI , Soh RYUZAKI
IPC: G01N27/447
CPC classification number: G01N27/44756 , G01N15/12 , G01N15/1218 , G01N33/48721 , G01N2015/1062 , G01N2015/1087 , G01N2015/1093
Abstract: According to one embodiment, provided is a single particle analyzing device including a measuring vessel, first and second chambers in the vessel defined by an insulating membrane, a pore opening in the membrane to connect the chambers, and first and second electrodes in the chambers. Electric current flows between the electrodes through the pore. Electrical characteristics are measured during migration of the target from the first chamber to the second chamber to measure the size and shape of the target. (a) t
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