公开(公告)号：US20150367034A1

公开(公告)日：2015-12-24

申请号：US14763146

申请日：2014-01-24

申请人： OSAKA UNIVERSITY

发明人： Hideki Yoshikawa ,  Norimasa Nakamura ,  Kazunori Shimomura ,  Yu Moriguchi ,  Ryota Chijimatsu ,  Yukihiko Yasui

IPC分类号： A61L27/38 ,  A61L27/36 ,  A61L27/12 ,  C12N5/0775

CPC分类号： A61L27/3834 ,  A61L27/12 ,  A61L27/3633 ,  A61L27/54 ,  A61L2300/414 ,  A61L2400/06 ,  A61L2430/02 ,  A61L2430/06 ,  A61L2430/24 ,  C12N5/0662 ,  C12N2500/30 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/38 ,  C12N2501/115 ,  C12N2506/02 ,  C12N2533/90

摘要： Provided are an improved three-dimensional synthetic tissue, a composite tissue thereof, and a production method of the same. The present invention provides: an implantable synthetic tissue substantially made of a mesenchymal stem cell induced from a pluripotent stem cell or an equivalent cell thereof, and an extracellular matrix derived from the cell; a composite tissue for treating or preventing a disease, disorder, or condition associated with an osteochondral defect, comprising a synthetic tissue and an artificial bone, wherein the artificial bone is smaller in size than a depth of a defect of a bone section in the osteochondral defect; and a production method of the same.

摘要翻译： 提供一种改进的三维合成组织，其复合组织及其制备方法。 本发明提供：基本上由多能干细胞或其等效细胞诱导的间充质干细胞制成的可植入合成组织和源自细胞的细胞外基质; 用于治疗或预防与骨软骨缺损有关的疾病，病症或病症的复合组织，包括合成组织和人造骨，其中所述人造骨的尺寸小于骨软骨中的骨段的缺损深度 缺陷; 及其制造方法。