公开(公告)号：US20200023045A1

公开(公告)日：2020-01-23

申请号：US16486768

申请日：2018-02-20

申请人： OSAKA UNIVERSITY ,  FUNPEP CO., LTD.

发明人： Munehisa SHIMAMURA ,  Tomohiro KAWANO ,  Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Hideki MOCHIZUKI ,  Akiko TENMA ,  Takako EHARA

IPC分类号： A61K39/00 ,  A61K47/42 ,  A61P9/10 ,  A61P7/02 ,  C07K14/435 ,  A61K39/39

摘要： Provided is an immunogenic composition comprising an antigenic peptide capable of inducing production of a neutralizing antibody against S100A9 and a carrier protein. The immunogenic composition can be used as a highly safe antithrombotic vaccine having antithrombotic effect without a long-term bleeding risk and is useful for the prevention of a disease associated with thrombus formation in which platelet aggregation is involved, particularly for the prevention of recurrent ischemic stroke.