公开(公告)号：US20200023045A1

公开(公告)日：2020-01-23

申请号：US16486768

申请日：2018-02-20

申请人： OSAKA UNIVERSITY ,  FUNPEP CO., LTD.

发明人： Munehisa SHIMAMURA ,  Tomohiro KAWANO ,  Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Hideki MOCHIZUKI ,  Akiko TENMA ,  Takako EHARA

IPC分类号： A61K39/00 ,  A61K47/42 ,  A61P9/10 ,  A61P7/02 ,  C07K14/435 ,  A61K39/39

摘要： Provided is an immunogenic composition comprising an antigenic peptide capable of inducing production of a neutralizing antibody against S100A9 and a carrier protein. The immunogenic composition can be used as a highly safe antithrombotic vaccine having antithrombotic effect without a long-term bleeding risk and is useful for the prevention of a disease associated with thrombus formation in which platelet aggregation is involved, particularly for the prevention of recurrent ischemic stroke.

公开(公告)号：US20230374103A1

公开(公告)日：2023-11-23

申请号：US18027695

申请日：2021-09-27

申请人： OSAKA UNIVERSITY

发明人： Munehisa SHIMAMURA ,  Hironori NAKAGAMI ,  Ryuichi MORISHITA

IPC分类号： C07K14/705 ,  A61P11/00 ,  A61P35/00

CPC分类号： C07K14/70575 ,  A61P11/00 ,  A61P35/00 ,  A61K38/00

摘要： Provided are preventive or therapeutic agents for fibrotic diseases and cancer. A Wnt signaling pathway inhibitor or a preventive and therapeutic agent for fibrotic diseases or cancer, both comprising an oligopeptide consisting of an amino acid sequence containing a DE loop sequence of RANKL protein and a β-strand sequence of RANKL protein placed adjacent to the N-terminal side of the DE loop sequence.