公开(公告)号：US20200023045A1

公开(公告)日：2020-01-23

申请号：US16486768

申请日：2018-02-20

申请人： OSAKA UNIVERSITY ,  FUNPEP CO., LTD.

发明人： Munehisa SHIMAMURA ,  Tomohiro KAWANO ,  Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Hideki MOCHIZUKI ,  Akiko TENMA ,  Takako EHARA

IPC分类号： A61K39/00 ,  A61K47/42 ,  A61P9/10 ,  A61P7/02 ,  C07K14/435 ,  A61K39/39

摘要： Provided is an immunogenic composition comprising an antigenic peptide capable of inducing production of a neutralizing antibody against S100A9 and a carrier protein. The immunogenic composition can be used as a highly safe antithrombotic vaccine having antithrombotic effect without a long-term bleeding risk and is useful for the prevention of a disease associated with thrombus formation in which platelet aggregation is involved, particularly for the prevention of recurrent ischemic stroke.

公开(公告)号：US20190105388A1

公开(公告)日：2019-04-11

申请号：US16087799

申请日：2017-03-24

申请人： OSAKA UNIVERSITY ,  FUNPEP CO., LTD.

发明人： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Akiko TENMA

IPC分类号： A61K39/39 ,  A61P37/04 ,  A61K39/395 ,  A61K39/00

摘要： The present invention provides a vaccine containing a complex of a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and an epitope of a disease-causing biological protein such as DPP4, IL-17A, IgE, S100A9 or PCSK9, which vaccine uses a less antigenic carrier protein and is capable of inducing antibody production to serve as an effective vaccine.

公开(公告)号：US20210205446A1

公开(公告)日：2021-07-08

申请号：US17200552

申请日：2021-03-12

申请人： OSAKA UNIVERSITY ,  FUNPEP CO., LTD.

发明人： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Akiko TENMA

IPC分类号： A61K39/39 ,  A61K39/00 ,  A61P37/04 ,  A61K39/395

摘要： The present invention provides a vaccine containing a complex of a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and an epitope of a disease-causing biological protein such as DPP4, IL-17A, IgE, S100A9 or PCSK9, which vaccine uses a less antigenic carrier protein and is capable of inducing antibody production to serve as an effective vaccine.

公开(公告)号：US20170275336A1

公开(公告)日：2017-09-28

申请号：US15514310

申请日：2015-09-25

申请人： OSAKA UNIVERSITY

发明人： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Hiroshi KORIYAMA ,  Akiko TENMA

IPC分类号： C07K7/08 ,  A61K8/64 ,  A61Q7/00 ,  A61K39/39

CPC分类号： C07K7/08 ,  A61K8/64 ,  A61K38/00 ,  A61K39/39 ,  A61K2039/55516 ,  A61Q7/00

摘要： An object of the present invention is to provide a novel peptide and a novel immunostimulant or hair grower containing the peptide as an active ingredient. The present invention provides a peptide of 23 or less amino acids comprising the amino acid sequence LHRLKRLRKRL (SEQ ID NO: 1), preferably the amino acid sequence LHRLKRLRKRLK (SEQ ID NO: 9), and also provides an immunostimulant containing the peptide, a vaccine adjuvant containing the peptide, a vaccine composition containing the peptide, and a hair grower containing the peptide.