公开(公告)号：US20240309051A1

公开(公告)日：2024-09-19

申请号：US18282385

申请日：2022-03-15

申请人： OSAKA UNIVERSITY ,  KOTAI Biotechnologies, Inc.

发明人： Sho Yamasaki ,  Xiuyuan Lu ,  Yuki Hosono ,  Shigenari Ishizuka ,  Kazuo Yamashita ,  Nicolas Claude Paul Sax

IPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K16/28

CPC分类号： C07K14/005 ,  C07K16/2809 ,  A61K38/00 ,  A61K2039/572 ,  C12N2770/20022 ,  C12N2770/20034

摘要： Follicular helper T cells specific to SARS-COV-2 virus are provided. The present disclosure is based on the finding of public TfhTCR specific to spike (S) protein common to various patients, and has identified for the first time a public TCR specific to the SARS-COV-2 virus and its MHC and antigenic epitopes to promote efficient immune responses, particularly those of B cells that produce neutralizing antibodies. For example, the present disclosure provides a composition containing an epitope specific to SARS-COV-2 virus for inducing a follicular T cell.

公开(公告)号：US20240159738A1

公开(公告)日：2024-05-16

申请号：US18282411

申请日：2022-03-15

申请人： OSAKA UNIVERSITY ,  KOTAI Biotechnologies, Inc.

发明人： Sho Yamasaki ,  Xiuyuan Lu ,  Yuki Hosono ,  Shigenari Ishizuka ,  Kazuo Yamashita ,  Nicolas Claude Paul Sax

IPC分类号： G01N33/50 ,  G16H10/60 ,  G16H20/10 ,  G16H50/20

CPC分类号： G01N33/505 ,  G16H10/60 ,  G16H20/10 ,  G16H50/20 ,  G01N2800/50 ,  G01N2800/52

摘要： A new medical technique using follicular T cells is provided. The present disclosure is based on the finding of public TfhTCR which is specific to disease factors common to various patients, and provides a method for producing follicular T cells specific to a disease, including a step of identifying a disease-related factor or a part thereof having the ability to induce a follicular T cell reactive with the disease-related factor, a step of inducing the follicular T cell specific to the disease, by using the disease-related factor or a part thereof, and a step of obtaining the follicular T cell specific to the disease.