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    PYRROLIDINE DERIVATIVES AS OXYTOCIN/VASOPRESSIN V1a RECEPTORS ANTAGONISTS
    1.
    发明申请
    PYRROLIDINE DERIVATIVES AS OXYTOCIN/VASOPRESSIN V1a RECEPTORS ANTAGONISTS 审中-公开
    吡咯啉衍生物作为氧合物/ VASOPRESSIN V1a受体拮抗剂

    公开(公告)号：US20160221944A1

    公开(公告)日：2016-08-04

    申请号：US14917847

    申请日：2014-07-25

    申请人： ObsEva S.A.

    发明人： Andre CHOLLET

    IPC分类号： C07D207/22

    摘要： The present invention relates to a compound of formula (3Z,5S)-5-(hydroxymethyl)-1-[(2′-methyl-1,1′-biphenyl-4-yl)carbonyl]pyrrolidin-3-one O-methl9243yloxime, and/or an active metabolite thereof having antagonist action at the oxytocin receptor and/or vasopressin V1a receptor, to processes for their preparation, pharmaceutical compositions containing them and their use.

    摘要翻译： 本发明涉及式（3Z，5S）-5-（羟甲基）-1 - [（2'-甲基-1,1'-联苯-4-基）羰基]吡咯烷-3-酮O- 甲基9243肟，和/或其在催产素受体和/或加压素V1a受体上具有拮抗作用的活性代谢物，其制备方法，含有它们的药物组合物及其用途。

    ORAL FORMULATIONS OF PYRROLIDINE DERIVATIVES
    2.
    发明申请
    ORAL FORMULATIONS OF PYRROLIDINE DERIVATIVES 审中-公开

    公开(公告)号：US20200281892A1

    公开(公告)日：2020-09-10

    申请号：US16569065

    申请日：2019-09-12

    申请人： ObsEva S.A.

    发明人： Andre CHOLLET ,  Oliver POHL

    IPC分类号： A61K31/40 ,  A61K31/401 ,  A61K9/20 ,  A61K9/00 ,  A61K47/40 ,  A61P15/08 ,  A61K45/06

    摘要： The present invention relates to solid oral formulations comprising a compound of formula (3Z,5S)-5-(hydroxymethyl)-1-[(2′-methyl-1,1′-biphenyl-4-yl)carbonyl]pyrrolidin-3-one-O-methyloxime, and/or an active metabolite thereof, and the use of said formulations in the treatment and/or prevention of preterm labor, premature birth, dysmenorrhea and embryo implantation failure due to uterine contractions. The present invention is furthermore related to processes for their preparation.

    PYRROLIDINE DERIVATIVES AS OXYTOCIN/VASOPRESSIN V1A RECEPTORS ANTAGONISTS
    4.
    发明申请
    PYRROLIDINE DERIVATIVES AS OXYTOCIN/VASOPRESSIN V1A RECEPTORS ANTAGONISTS 有权
    吡咯啉衍生物作为氧合物/ VASOPRESSIN V1A受体拮抗剂

    公开(公告)号：US20150073032A1

    公开(公告)日：2015-03-12

    申请号：US14479664

    申请日：2014-09-08

    申请人： ObsEva S.A.

    发明人： Andre CHOLLET

    IPC分类号： C07D207/22

    CPC分类号： C07D207/22 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/40 ,  C07D207/09

    摘要： The present invention relates to a compound of formula (3Z,5S)-5-(hydroxymethyl)-1-[(2′-methyl-1,1′-biphenyl-4-yl)carbonyl]pyrrolidin-3-one O-methy19243-yloxime, and/or an active metabolite thereof having antagonist action at the oxytocin receptor and/or vasopressin V1a receptor, to processes for their preparation, pharmaceutical compositions containing them and their use.

    摘要翻译： 本发明涉及式（3Z，5S）-5-（羟甲基）-1 - [（2'-甲基-1,1'-联苯-4-基）羰基]吡咯烷-3-酮O- methy19243-yloxime，和/或其在催产素受体和/或加压素V1a受体上具有拮抗作用的活性代谢物，其制备方法，含有它们的药物组合物及其用途。

    ORAL FORMULATIONS OF PYRROLIDINE DERIVATIVES
    10.
    发明申请
    ORAL FORMULATIONS OF PYRROLIDINE DERIVATIVES 审中-公开

    公开(公告)号：US20180311211A1

    公开(公告)日：2018-11-01

    申请号：US15952934

    申请日：2018-04-13

    申请人： ObsEva S.A.

    发明人： Andre CHOLLET ,  Oliver POHL

    IPC分类号： A61K31/40 ,  A61K31/401 ,  A61K9/20 ,  A61K45/06 ,  A61K9/00 ,  A61K47/40

    摘要： The present invention relates to solid oral formulations comprising a compound of formula (3Z,5S)-5-(hydroxymethyl)-1-[(2′-methyl-1,1′-biphenyl-4-yl)carbonyl]pyrrolidin-3-one-O-methyloxime, and/or an active metabolite thereof, and the use of said formulations in the treatment and/or prevention of preterm labor, premature birth, dysmenorrhea and embryo implantation failure due to uterine contractions. The present invention is furthermore related to processes for their preparation.