公开(公告)号：US20100318002A1

公开(公告)日：2010-12-16

申请号：US12813016

申请日：2010-06-10

申请人： Oleg Prus ,  Rita Schmidt ,  Eyal Zadicario ,  Shuki Vitek

发明人： Oleg Prus ,  Rita Schmidt ,  Eyal Zadicario ,  Shuki Vitek

IPC分类号： A61N7/00

CPC分类号： A61N7/00 ,  A61B8/0808 ,  A61B17/22004 ,  A61B17/22029 ,  A61B2017/00106 ,  A61B2017/22007 ,  A61B2017/22028 ,  A61N2007/0039 ,  A61N2007/0078

摘要： Ultrasound energy is delivered to a patient in a controlled manner using a focused ultrasound system, thus maintaining the desired therapeutic effect without causing unwanted damage to surrounding tissue. An ultrasound transducer device includes multiple transducer elements, each of which is controlled by drive circuitry and a drive signal controller. An acoustic detector detects signals indicative of cavitation in tissue targeted by the transducer elements, and the drive signal controller manages the delivery of acoustic energy from the transducer elements based on the detected cavitation signals such that a therapeutic effect at the target tissue remains within an efficacy range.

摘要翻译： 使用聚焦超声系统以可控的方式将超声能量传送给患者，从而保持所需的治疗效果，而不会对周围组织造成不必要的损伤。 超声换能器装置包括多个换能器元件，每个换能器元件由驱动电路和驱动信号控制器控制。 声学检测器检测指示由换能器元件所针对的组织中的气蚀的信号，并且驱动信号控制器基于检测到的空化信号来管理来自换能器元件的声能的传递，使得靶组织上的治疗效果保持在功效 范围。

公开(公告)号：US11872412B2

公开(公告)日：2024-01-16

申请号：US16112150

申请日：2018-08-24

申请人： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario

发明人： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario

IPC分类号： A61N7/00 ,  A61N7/02 ,  A61B90/00

CPC分类号： A61N7/00 ,  A61N7/02 ,  A61B2090/374 ,  A61N2007/0073 ,  A61N2007/0078

摘要： A system and method for selecting a patient-specific frequency for ultrasound therapy of a target within the patient are provided. The method includes: (a) for at least one segment of an ultrasound transducer and for each of a plurality of ultrasound frequencies within a test range, sonicating the target and measuring a parameter correlated with an amount of ultrasound energy absorbed in the target; and (b) for each said at least one segment, selecting for subsequent ultrasound therapy, among the frequencies within the test range, a frequency corresponding to a value of the measured parameter that itself corresponds to a maximum amount of ultrasound energy absorbed in the target.

公开(公告)号：US20190009109A1

公开(公告)日：2019-01-10

申请号：US16112150

申请日：2018-08-24

申请人： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario

发明人： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario

IPC分类号： A61N7/00

摘要： In ultrasound therapy, the frequency of sonications can be optimized, within a certain frequency range, to maximize the absorption or the acoustic intensity at the target in a manner specific to the patient.

公开(公告)号：US10589129B2

公开(公告)日：2020-03-17

申请号：US15265204

申请日：2016-09-14

申请人： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario ,  Yoav Levy

发明人： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario ,  Yoav Levy

IPC分类号： A61N7/00 ,  A61N7/02 ,  A61B5/055 ,  A61B34/10 ,  A61B17/22 ,  A61B8/08 ,  A61B90/00

摘要： Various approaches for reducing microbubble interference with ultrasound waves transmitted from multiple transducer elements and traversing tissue onto a target region include measuring microbubbles in high-throughput areas of ultrasound exposure and reducing the amount of microbubbles using the ultrasound waves.

公开(公告)号：US20120029396A1

公开(公告)日：2012-02-02

申请号：US13194286

申请日：2011-07-29

申请人： Kobi Vortman ,  Eyal Zadicario ,  Shuki Vitek

发明人： Kobi Vortman ,  Eyal Zadicario ,  Shuki Vitek

IPC分类号： A61N7/00

CPC分类号： A61N7/02 ,  A61B8/0808 ,  A61B2090/364 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2090/378

摘要： Treatment of moving tissue may be facilitated by identifying voxels within a volume of the tissue, associating treatment-related attributes with the voxels, and shifting positions of the voxels based on the tissue movement. One or more treatment parameters may then be altered based on the treatment-related attributes of the shifted voxels.

摘要翻译： 可以通过识别组织体积内的体素，将治疗相关属性与体素相关联，以及基于组织移动来移位体素的位置来促进移动组织的治疗。 然后可以基于移位体素的治疗相关属性来改变一个或多个治疗参数。

公开(公告)号：US11103731B2

公开(公告)日：2021-08-31

申请号：US15404412

申请日：2017-01-12

申请人： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario ,  Yoav Levy

发明人： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario ,  Yoav Levy

IPC分类号： A61N7/02 ,  A61B5/055 ,  A61B8/08 ,  A61N7/00 ,  A61B18/00 ,  A61B90/00

摘要： Various approaches for heating a target region substantially uniformly include identifying one or more locations of one or more hot spots in the target region and/or surrounding regions of the target region during an ultrasound sonication process; computing a temporal variation to an output parameter of at least one of the transducer elements based at least in part on the identified location(s) of the hot spot(s); and operating the at least one transducer element to achieve the temporal variation of the output parameter so as to minimize the hot spot(s).

公开(公告)号：US20160008633A1

公开(公告)日：2016-01-14

申请号：US14771894

申请日：2014-03-06

申请人： Kobi VORTMAN ,  Shuki VITEK ,  Eyal ZADICARIO ,  INSIGHTEC, LTD.

发明人： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario

IPC分类号： A61N7/00

CPC分类号： A61N7/00 ,  A61B2090/374 ,  A61N7/02 ,  A61N2007/0073 ,  A61N2007/0078

摘要： In ultrasound therapy, the frequency of sonications can be optimized, within a certain frequency range, to maximize the absorption or the acoustic intensity at the target in a manner specific to the patient.

摘要翻译： 在超声治疗中，可以在一定频率范围内优化声波的频率，以特定于患者的方式最大限度地增加靶上的吸收或声强。

公开(公告)号：US11291866B2

公开(公告)日：2022-04-05

申请号：US15837365

申请日：2017-12-11

申请人： Yoav Levy ,  Eyal Zadicario ,  Shuki Vitek ,  Javier Grinfeld ,  Ohad Silbiger

发明人： Yoav Levy ,  Eyal Zadicario ,  Shuki Vitek ,  Javier Grinfeld ,  Ohad Silbiger

IPC分类号： A61B8/00 ,  A61B8/08 ,  G01S15/89 ,  G01S7/52 ,  A61B5/01 ,  A61B5/055 ,  A61N7/02 ,  A61N7/00 ,  A61B17/22 ,  A61B34/10

摘要： Various approaches to generating and maintaining an ultrasound focus at a target region include configuring a controller to cause transmission of treatment ultrasound pulses from a transducer having multiple transducer elements; cause the transducer to transmit focusing ultrasound pulses to the target region and generate an acoustic reflector therein; measure reflections of the focusing ultrasound pulses from the acoustic reflector; based at least in part on the measured reflections, adjust a parameter value associated with one or more transducer elements so as to maintain and/or improve the ultrasound focus at the target region.

公开(公告)号：US10456603B2

公开(公告)日：2019-10-29

申请号：US14566040

申请日：2014-12-10

申请人： Tal Tlusty ,  Shuki Vitek ,  Eyal Zadicario

发明人： Tal Tlusty ,  Shuki Vitek ,  Eyal Zadicario

IPC分类号： A61N7/00 ,  A61B8/08 ,  A61N7/02 ,  A61B5/00 ,  A61B6/03 ,  A61B6/00 ,  A61B34/10 ,  A61B90/00 ,  A61B90/10

摘要： Skull inhomogeneity may be quantified in accordance with the skull density measured in skull images acquired using a conventional imager; the quantified inhomogeneity may then be used to determine whether the patient is suitable for ultrasound treatment and/or determine parameters associated with the ultrasound transducer for optimizing transskull ultrasound treatment.

公开(公告)号：US20160184026A1

公开(公告)日：2016-06-30

申请号：US14566040

申请日：2014-12-10

申请人： Tal Tlusty ,  Shuki Vitek ,  Eyal Zadicario

发明人： Tal Tlusty ,  Shuki Vitek ,  Eyal Zadicario

IPC分类号： A61B19/00 ,  A61B6/03 ,  A61B8/08 ,  A61B5/00 ,  A61N7/00 ,  A61B5/055

摘要： Skull inhomogeneity may be quantified in accordance with the skull density measured in skull images acquired using a conventional imager; the quantified inhomogeneity may then be used to determine whether the patient is suitable for ultrasound treatment and/or determine parameters associated with the ultrasound transducer for optimizing transskull ultrasound treatment.

摘要翻译： 颅骨不均匀性可以根据使用常规成像器获取的颅骨图像中测量的颅骨密度进行量化; 然后可以使用量化的不均匀性来确定患者是否适合于超声治疗和/或确定与超声换能器相关联的参数以优化transskull超声治疗。