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1.发明授权Method for determining the ability of a compound to modify the interaction between parkin and the p38 protein 有权确定化合物修饰parkin和p38蛋白之间相互作用的能力的方法公开(公告)号：US07070940B2
公开(公告)日：2006-07-04
申请号：US10622817
申请日：2003-07-18
申请人： Olga Corti , Cornelia Hampe , Alexis Brice , Laurent Pradier , Thomas Rooney , Alain Fournier
发明人： Olga Corti , Cornelia Hampe , Alexis Brice , Laurent Pradier , Thomas Rooney , Alain Fournier
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/47
摘要： The present invention relates to a method for determining the ability of a compound to modify the interaction between parkin and the p38 protein, and in particular to a method for screening for or detecting compounds intended for the prevention and/or treatment of neurodegenerative pathological conditions. The present inventions also relates to compounds identified in the above screening method.
摘要翻译： 本发明涉及一种测定化合物修饰parkin和p38蛋白之间相互作用的能力的方法，特别涉及用于筛选或检测旨在预防和/或治疗神经变性病理状况的化合物的方法 。 本发明还涉及上述筛选方法鉴定的化合物。
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2.发明申请Chimeric Polypeptides Useful in Proximal and Dynamic High-Throughput Screening Methods 审中-公开嵌合多肽可用于近端和动态高通量筛选方法公开(公告)号：US20130035256A1
公开(公告)日：2013-02-07
申请号：US13640332
申请日：2011-04-20
CPC分类号： G01N33/542 , C07K14/4722 , C07K14/705 , C07K14/723 , C07K2319/60 , C07K2319/74 , G01N2333/4719 , G01N2333/726 , G01N2500/10
摘要： The present invention provides a method of high-throughput screening (HTS) of active agents of a cell-surface G-Protein coupled receptor (GPCR) or another target receptor of interest. The method uses a non-invasive, sensitive reporting system that is proximal to the target of interest, combined with a dynamic, automated screening procedure so as to detect orthosteric ligands, such as agonists and antagonists, but is also suitable to detect allosteric or low affinity active agents of a GPCR and possibly other disease-related receptors.
摘要翻译： 本发明提供了细胞表面G蛋白偶联受体（GPCR）或感兴趣的另一靶受体的活性剂的高通量筛选（HTS）的方法。 该方法使用接近感兴趣目标的非侵入性敏感报告系统，结合动态的自动筛选程序，以便检测正畸配体，例如激动剂和拮抗剂，但也适用于检测变构或低位 GPCR的亲和力活性剂和可能的其它疾病相关受体。
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