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    Use of aminoindazole derivatives for the inhibition of tau phosphorylation
    2.
    发明授权
    Use of aminoindazole derivatives for the inhibition of tau phosphorylation 失效
    氨基吲唑衍生物用于抑制tau磷酸化

    公开(公告)号：US07629374B2

    公开(公告)日：2009-12-08

    申请号：US12143070

    申请日：2008-06-20

    申请人： Dominique Lesuisse ,  Gilles Dutruc-Rosset ,  Franck Halley ,  Didier Babin ,  Thomas Rooney ,  Gilles Tiraboschi

    发明人： Dominique Lesuisse ,  Gilles Dutruc-Rosset ,  Franck Halley ,  Didier Babin ,  Thomas Rooney ,  Gilles Tiraboschi

    IPC分类号： A61K31/415

    CPC分类号： C07D231/56 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/427 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  C07D403/12 ,  C07D405/12

    摘要： The present invention relates to the use of novel derivatives of general formula (I) in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, COOR1, SO2R1, C(═NH)R1 or C(═NH)NR1 radical; R5, R6 and R7 are, independently of one another, chosen from the following radicals: halogen, CN, NO2, NH2, OH, OR8, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2NR8R9, —O—SO2R8, —SO2—O—R8, trifluoromethyl, trifluoromethoxy, (1-6C)alkyl, (1-6C)alkoxy, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, heterocycle, cycloalkyl, alkenyl, alkynyl, adamantyl or polycycloalkyl, to treat a disease selected from the group consisting of: neurodegenerative diseases, strokes, cranial and spinal traumas and peripheral neuropathies, obesity, metabolic diseases, type II diabetes, essential hypertension, atherosclerotic cardiovascular diseases, polycystic ovaries syndrome, syndrome X, immunodeficiency and cancer.

    摘要翻译： 本发明涉及通式（I）的新型衍生物，其中R3是（1-6C）烷基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，芳基或 与（1-10C）环烷基，杂环，杂环烷基，环烷基，金刚烷基，多环烷基，烯基，炔基，CONR1R2，COOR1，SO2R1，C（-NH）R1或C（-NH）NR1基团稠合的杂芳基） R 5，R 6和R 7彼此独立地选自以下基团：卤素，CN，NO 2，NH 2，OH，OR 8，COOH，C（O）OR 8，-OC（O）R 8，NR 8 R 9，NHC ）R8，C（O）NR8R9，NHC（S）R8，C（S）NR8R9，SR8，S（O）R8，SO2R8，NHSO2R8，SO2NR8R9，-O-SO2R8，-SO2-O-R8，三氟甲基，三氟甲氧基 ，（1-6C）烷基，（1-6C）烷氧基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，杂环，环烷基，烯基，炔基，金刚烷基或多环烷基， 选自以下的疾病：神经变性疾病，中风，颅脑和脊髓创伤和周围神经病变，肥胖症，代谢疾病，II型糖尿病，原发性高血压，动脉粥样硬化性心血管疾病，多囊卵巢综合征，综合征X，免疫缺陷和癌症。

    OFFSHORE HYDROELECTRIC TURBINE ASSEMBLY AND METHOD
    3.
    发明申请
    OFFSHORE HYDROELECTRIC TURBINE ASSEMBLY AND METHOD 失效
    海洋水电涡轮组件及方法

    公开(公告)号：US20120257955A1

    公开(公告)日：2012-10-11

    申请号：US13444113

    申请日：2012-04-11

    申请人： Thomas Rooney

    发明人： Thomas Rooney

    IPC分类号： F01D25/28

    CPC分类号： F03B13/10 ,  F03B17/061 ,  F05B2240/13 ,  F05B2240/40 ,  F05B2250/232 ,  F05B2270/18 ,  Y02E10/22 ,  Y02E10/28

    摘要： The invention is directed to a single moored offshore marine turbine assembly having a central control vessel which includes a main vessel tethered to a control buoy. The main vessel having a first cap, a corresponding second cap and a tubular shell positioned between both the first cap and second cap. The tubular shell contains one or more vertical partitions to assist in ballasting. The control buoy includes a compressor and an air conduit which forces air into the main vessel through a manifold. A hollow suction caisson affixes the central control vessel to the ocean floor. A taut line mooring secures the suction caisson to the main vessel. Electricity is generated via a turbine shroud assembly having a conical shroud and a hydro-turbine. By attaching a plurality of turbine shroud assemblies in series via cables, a horizontal turbine array is formed resulting in a simple, economical and safe layout.

    摘要翻译： 本发明涉及一种具有中央控制容器的单个系泊海上涡轮机组件，该中央控制容器包括连接到控制浮标的主船。 主容器具有第一盖，相应的第二盖和位于第一盖和第二盖之间的管状壳。 管状壳体包含一个或多个垂直隔板以辅助压载。 控制浮标包括压缩机和通过歧管迫使空气进入主容器的空气管道。 空心抽吸沉箱将中央控制船舶固定在海底。 拉紧系泊系统将吸力沉箱固定在主船上。 通过具有锥形护罩和水轮机的涡轮机护罩组件产生电力。 通过经由电缆将多个涡轮机护罩组件串联连接，形成水平涡轮机阵列，从而形成简单，经济和安全的布局。

    Aminoindazole derivatives as medicaments and pharmaceutical compositions including them
    4.
    发明授权
    Aminoindazole derivatives as medicaments and pharmaceutical compositions including them 有权
    氨基吲唑衍生物作为药物和药物组合物，包括它们

    公开(公告)号：US07582669B2

    公开(公告)日：2009-09-01

    申请号：US11567442

    申请日：2006-12-06

    申请人： Dominique Lesuisse ,  Gilles Dutruc-Rosset ,  Franck Halley ,  Didier Babin ,  Thomas Rooney

    发明人： Dominique Lesuisse ,  Gilles Dutruc-Rosset ,  Franck Halley ,  Didier Babin ,  Thomas Rooney

    IPC分类号： A61K31/416

    CPC分类号： C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

    摘要： The present invention relates to novel derivatives of general formula (I) in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, COOR1, SO2R1, C(═NH)R1 or C(═NH)NR1 radical; R5 and R6 are, independently of one another, chosen from the following radicals: halogen, CN, NO2, NH2, OH, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2NR8R9, —O—SO2R8, —SO2—O—R8, trifluoromethyl, trifluoromethoxy, (1-6C)alkyl, (1-6C)alkoxy, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, heterocycle, cycloalkyl, alkenyl, alkynyl, adamantyl or polycycloalkyl.

    摘要翻译： 本发明涉及通式（I）的新型衍生物，其中R3是（1-6C）烷基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，芳基或杂芳基 （1-10C）环烷基，杂环，杂环烷基，环烷基，金刚烷基，多环烷基，烯基，炔基，CONR1R2，COOR1，SO2R1，C（-NH）R1或C（-NH）NR1基; R 5和R 6彼此独立地选自以下基团：卤素，CN，NO 2，NH 2，OH，COOH，C（O）OR 8，-OC（O）R 8，NR 8 R 9，NHC（O） （O）NR8R9，NHC（S）R8，C（S）NR8R9，SR8，S（O）R8，SO2R8，NHSO2R8，SO2NR8R9，-O-SO2R8，-SO2-O-R8，三氟甲基，三氟甲氧基，（1- 6C）烷基，（1-6C）烷氧基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，杂环，环烷基，烯基，炔基，金刚烷基或多环烷基。

    NOVEL AMINOINDAZOLE DERIVATIVES AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS INCLUDING THEM
    5.
    发明申请
    NOVEL AMINOINDAZOLE DERIVATIVES AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS INCLUDING THEM 有权
    作为药物和药物组合物的新型氨基咔唑衍生物包括它们

    公开(公告)号：US20070093479A1

    公开(公告)日：2007-04-26

    申请号：US11567442

    申请日：2006-12-06

    申请人： Dominique Lesuisse ,  Gilles Dutruc-Rosset ,  Franck Halley ,  Didier Babin ,  Thomas Rooney

    发明人： Dominique Lesuisse ,  Gilles Dutruc-Rosset ,  Franck Halley ,  Didier Babin ,  Thomas Rooney

    IPC分类号： A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  A61K31/427 ,  A61K31/416

    CPC分类号： C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

    摘要： The present invention relates to novel derivatives of general formula (I) in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, COOR1, SO2R1, C(═NH)R1 or C(═NH)NR1 radical; R5 and R6 are, independently of one another, chosen from the following radicals: halogen, CN, NO2, NH2, OH, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2NR8R9, —O—SO2R8, —SO2—O—R8, trifluoromethyl, trifluoromethoxy, (1-6C)alkyl, (1-6C)alkoxy, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, heterocycle, cycloalkyl, alkenyl, alkynyl, adamantyl or polycycloalkyl.

    摘要翻译： 本发明涉及通式（I）的新型衍生物，其中R3是（1-6C）烷基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，芳基或杂芳基 （1-10C）环烷基，杂环，杂环烷基，环烷基，金刚烷基，多环烷基，烯基，炔基，CONR1R2，COOR1，SO2R1，C（-NH）R1或C（-NH）NR1 激进; R 5和R 6彼此独立地选自以下基团：卤素，CN，NO 2，NH 2，OH，COOH，C（O）OR 8， -OC（O）R8，NR8R9，NHC（O）R8，C（O）NR8R9，NHC（S）R8，C（S）NR8R9，SR8，S（O） R 8，NHSO 2 R 8，SO 2 NR 8 R 9，-O-SO 2 R 8，-SO 2 -O （1-6C）烷氧基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，杂环，环烷基，链烯基，炔基，金刚烷基 或多环烷基。

    Aminoindazole derivatives as medicaments and pharmaceutical compositions including them
    9.
    发明授权
    Aminoindazole derivatives as medicaments and pharmaceutical compositions including them 有权
    氨基吲唑衍生物作为药物和药物组合物，包括它们

    公开(公告)号：US07166629B2

    公开(公告)日：2007-01-23

    申请号：US10654703

    申请日：2003-09-04

    申请人： Dominique Lesuisse ,  Gilles Dutruc-Rosset ,  Franck Halley ,  Didier Babin ,  Thomas Rooney

    发明人： Dominique Lesuisse ,  Gilles Dutruc-Rosset ,  Franck Halley ,  Didier Babin ,  Thomas Rooney

    IPC分类号： A61K31/416 ,  C07D231/56

    CPC分类号： C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

    摘要： The present invention relates to novel derivatives of general formula (I) in which R3 is a (1–6C)alkyl, aryl, aryl(1–6C)alkyl, heteroaryl, heteroaryl(1–6C)alkyl, aryl or heteroaryl fused to a (1–10C)cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, COOR1, SO2R1, C(═NH)R1 or C(═NH)NR1 radical; R5 and R6 are, independently of one another, chosen from the following radicals: halogen, CN, NO2, NH2, OH, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2NR8R9, —O—SO2R8, —SO2—O—R8, trifluoromethyl, trifluoromethoxy, (1–6C)alkyl, (1–6C)alkoxy, aryl, aryl(1–6C)alkyl, heteroaryl, heteroaryl(1–6C)alkyl, heterocycle, cycloalkyl, alkenyl, alkynyl, adamantyl or polycycloalkyl.

    摘要翻译： 本发明涉及通式（I）的新型衍生物，其中R3是（1-6C）烷基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，芳基或杂芳基 （1-10C）环烷基，杂环，杂环烷基，环烷基，金刚烷基，多环烷基，烯基，炔基，CONR1R2，COOR1，SO2R1，C（-NH）R1或C（-NH）NR1 激进; R 5和R 6彼此独立地选自以下基团：卤素，CN，NO 2，NH 2，OH，COOH，C（O）OR 8， -OC（O）R8，NR8R9，NHC（O）R8，C（O）NR8R9，NHC（S）R8，C（S）NR8R9，SR8，S（O） R 8，NHSO 2 R 8，SO 2 NR 8 R 9，-O-SO 2 R 8，-SO 2 -O （1-6C）烷氧基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，杂环，环烷基，链烯基，炔基，金刚烷基 或多环烷基。