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    USE OF LANTHANIDE-BASED NANOPARTICLES AS RADIOSENSITIZING AGENTS
    3.
    发明申请
    USE OF LANTHANIDE-BASED NANOPARTICLES AS RADIOSENSITIZING AGENTS 审中-公开
    使用作为放射增敏剂的基于兰氢化合物的纳米粒子

    公开(公告)号：US20110027375A1

    公开(公告)日：2011-02-03

    申请号：US12738191

    申请日：2008-10-14

    申请人： Olivier Tillement ,  Stéphane Roux ,  Pascal Perriat ,  Géraldine Leduc ,  Céline Mandon ,  Brice Mutelet ,  Christophe Alric ,  Claire Billotey ,  Marc Janier ,  Cédric Louis

    发明人： Olivier Tillement ,  Stéphane Roux ,  Pascal Perriat ,  Géraldine Leduc ,  Céline Mandon ,  Brice Mutelet ,  Christophe Alric ,  Claire Billotey ,  Marc Janier ,  Cédric Louis

    IPC分类号： A61K9/14 ,  A61K33/24 ,  A61P35/00

    CPC分类号： A61K41/0038 ,  A61K9/0019

    摘要： The invention relates to the use of nanoparticles with dimensions comprised between 1 and 50 nm, at least one portion of which consists of at least one oxide and/or one oxohydroxide of at least one lanthanide, said nanoparticles: either consisting of at least one oxide and/or one oxohydroxide of at least one lanthanide, or in the form of nanoparticles comprising a core consisting of at least one oxide and/or one oxohydroxide of at least one lanthanide, and a coating consisting of polysiloxane, with possibly organic molecules grafted at the surface or comprised inside it, as a radio-sensitizing agent in the making of an injectable composition intended to improve the efficiency of the treatment of a tumor by X or gamma irradiations. It also relates to nanoparticles particularly suitable for the use above, consisting of a core consisting of at least one oxide and/or one oxohydroxide of at least one lanthanide and of a coating in polysiloxane comprising 1 to 5 silicon atoms per lanthanide and at least 10% of the silicon atoms of which are bound to hydrophilic organic molecules with molar masses of less than 450 g/mol.

    摘要翻译： 本发明涉及使用尺寸为1至50nm的纳米颗粒，其至少一部分由至少一种镧系元素的至少一种氧化物和/或一种氧代氢氧化物组成，所述纳米颗粒由至少一种氧化物 或至少一种镧系元素的一种氧代氢氧化物，或纳米颗粒的形式，其包含由至少一种镧系元素的至少一种氧化物和/或一种氧代氢氧化物构成的核心，以及由聚硅氧烷组成的涂层，可能的有机分子被接枝在 表面或其内部，作为用于通过X或γ照射提高肿瘤治疗效率的可注射组合物的放射性增感剂。 它还涉及特别适合于上述用途的纳米颗粒，其由至少一种镧系元素的至少一种氧化物和/或一种氧代氢氧化物和每镧系元素含有1至5个硅原子的聚硅氧烷中的涂层和至少10个 其硅原子的％与摩尔质量小于450g / mol的亲水性有机分子结合。

    ULTRAFINE NANOPARTICLES COMPRISING A FUNCTIONALIZED POLYORGANOSILOXANE MATRIX AND INCLUDING METAL COMPLEXES; METHOD FOR OBTAINING SAME AND USES THEREOF IN MEDICAL IMAGING AND/OR THERAPY
    4.
    发明申请
    ULTRAFINE NANOPARTICLES COMPRISING A FUNCTIONALIZED POLYORGANOSILOXANE MATRIX AND INCLUDING METAL COMPLEXES; METHOD FOR OBTAINING SAME AND USES THEREOF IN MEDICAL IMAGING AND/OR THERAPY 审中-公开
    包含官能化聚硅氧烷基质并包括金属络合物的超纳米纳米粒子; 用于获得其的方法及其在医学成像和/或治疗中的用途

    公开(公告)号：US20130195766A1

    公开(公告)日：2013-08-01

    申请号：US13695090

    申请日：2011-05-02

    申请人： François Lux ,  Olivier Tillement ,  Maxime Saint Jean ,  Pierre Mowat ,  Pascal Perriat ,  Stéphane Roux ,  Anna Mignot

    发明人： François Lux ,  Olivier Tillement ,  Maxime Saint Jean ,  Pierre Mowat ,  Pascal Perriat ,  Stéphane Roux ,  Anna Mignot

    IPC分类号： A61K49/18 ,  A61K9/14

    摘要： The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy.The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.Thus, the nanoparticles according to the invention, with diameter d1 between 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations optionally associated with doping cations; a chelating graft C1 DTPABA (diethylenetriaminepentaacetic acid bisanhydride) bound to the POS matrix by an —Si—C— covalent bond, and present in sufficient quantity to be able to complex all the gadolinium cations; and optionally another functionalizing graft Gf* bound to the POS matrix by an —Si—C— covalent bond (where Gf* can be derived from a hydrophilic compound (PEG); from a compound having an active ingredient PA1; from a targeting compound; from a luminescent compound (fluorescein).The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.

    摘要翻译： 本发明涉及非常小尺寸的新型生物相容性杂合纳米粒子，特别适用于诊断和/或治疗。 本发明的目的是提供新颖的纳米颗粒，其特别用作成像（例如MRI）和/或其它诊断技术和/或作为治疗剂的造影剂，其比具有相同类型的已知纳米颗粒更好的性能 并且其结合了小尺寸（例如小于20nm）和高负载金属（例如稀土），特别是在成像（例如MRI）中，具有强烈的强化和正确的响应（增加的弛豫性 ）在高频率。 因此，直径d1在1和20nm之间的根据本发明的纳米颗粒各自包含聚有机硅氧烷（POS）基质，其包含任选与掺杂阳离子相关的钆阳离子; 通过-Si-C-共价键与POS基质结合的螯合接枝C1DTPABA（二亚乙基三胺五乙酸双酐），并且以足够的量存在以能够使所有的钆阳离子复合; 和任选的通过-Si-C-共价键（其中Gf *可以衍生自亲水性化合物（PEG））与POS基质结合的另一个官能化移植物Gf *;具有活性成分PA1的化合物;来自靶向化合物; 来自发光化合物（荧光素）的方法。用于制备这些纳米颗粒的方法及其在成像和治疗中的应用也构成本发明的一部分。

    Use of nanoparticles for labelling oil field injection waters
    6.
    发明授权
    Use of nanoparticles for labelling oil field injection waters 有权
    使用纳米颗粒标记油田注射水

    公开(公告)号：US09260957B2

    公开(公告)日：2016-02-16

    申请号：US13518827

    申请日：2010-12-22

    申请人： Annie Commarieu ,  Fabrice Aubertin ,  Nicolas Crowther ,  Cédric Louis ,  Pascal Perriat ,  Matteo Martini ,  Olivier Tillement

    发明人： Annie Commarieu ,  Fabrice Aubertin ,  Nicolas Crowther ,  Cédric Louis ,  Pascal Perriat ,  Matteo Martini ,  Olivier Tillement

    IPC分类号： G01N21/64 ,  E21B47/00 ,  C09K8/03 ,  C09K8/58 ,  E21B47/10 ,  C09K11/59 ,  B82Y15/00

    CPC分类号： E21B47/00 ,  B82Y15/00 ,  C09K8/03 ,  C09K8/58 ,  C09K11/06 ,  C09K11/592 ,  E21B47/1015 ,  G01N21/64 ,  Y10S977/773 ,  Y10S977/902

    摘要： The present invention relates to the development of tracer fluids, more generally, that of aqueous liquids, intended to be injected under pressure in an oil reservoir, for example from an injection well up to a production well.The object of the invention is to propose a new method of study of a solid medium, i.e. an oil reservoir, by diffusion of a liquid (i.e. injection waters) containing tracers, through said solid medium, which is simple to implement and economical and which remedies the drawbacks of the known tracers for injection waters of oil reservoirs.This method essentially consisting of injecting, in this solid medium, an injection liquid comprising a nanoparticle-based tracer having average dimensions comprised between 20 and 200 nm, detectable by means of one or several S signals at dilutions of less than or equal to 10−7, adapted to form a stable colloidal suspension in a saline medium, at least a portion of which is constituted of a core and a coating provided with an adjustable hydrophilic-lipophilic balance (HLB) and comprising at least one organic and/or organosilicon component; recovering the liquid having diffused; and analyzing this liquid having diffused to measure the quantity of tracer by detection of the signal or signals S.

    摘要翻译： 本发明涉及示踪流体的开发，更一般地说，旨在在储油器中例如从注入井到生产井的压力下注入含水液体。 本发明的目的是提出一种通过所述固体介质通过扩散含有示踪剂的液体（即注射水）的固体介质，即储油器的研究的新方法，所述固体介质易于实施和经济，并且其中 弥补了油藏注射水已知示踪剂的缺点。 该方法基本上包括在该固体培养基中注入含有平均尺寸在20和200nm之间的纳米颗粒型示踪剂的注射液，其可以通过少于或等于10- 7，适于在盐水介质中形成稳定的胶体悬浮液，其至少一部分由芯和具有可调亲水亲油平衡（HLB）的涂层构成，并且包含至少一种有机和/或有机硅组分 ; 回收扩散的液体; 并且通过检测信号或信号S来分析扩散的液体以测量示踪剂的量。

    USE OF NANOPARTICLES FOR LABELLING OIL FIELD INJECTION WATERS
    7.
    发明申请
    USE OF NANOPARTICLES FOR LABELLING OIL FIELD INJECTION WATERS 有权
    用于标记油田注射水的纳米颗粒的使用

    公开(公告)号：US20130084643A1

    公开(公告)日：2013-04-04

    申请号：US13518827

    申请日：2010-12-22

    申请人： Annie Commarieu ,  Fabrice Aubertin ,  Nicolas Crowther ,  Cédric Louis ,  Pascal Perriat ,  Matteo Martini ,  Olivier Tillement

    发明人： Annie Commarieu ,  Fabrice Aubertin ,  Nicolas Crowther ,  Cédric Louis ,  Pascal Perriat ,  Matteo Martini ,  Olivier Tillement

    IPC分类号： E21B47/00 ,  G01N21/64 ,  C09K11/59

    CPC分类号： E21B47/00 ,  B82Y15/00 ,  C09K8/03 ,  C09K8/58 ,  C09K11/06 ,  C09K11/592 ,  E21B47/1015 ,  G01N21/64 ,  Y10S977/773 ,  Y10S977/902

    摘要： The present invention relates to the development of tracer fluids, more generally, that of aqueous liquids, intended to be injected under pressure in an oil reservoir, for example from an injection well up to a production well.The object of the invention is to propose a new method of study of a solid medium, i.e. an oil reservoir, by diffusion of a liquid (i.e. injection waters) containing tracers, through said solid medium, which is simple to implement and economical and which remedies the drawbacks of the known tracers for injection waters of oil reservoirs.This method essentially consisting of injecting, in this solid medium, an injection liquid comprising a nanoparticle-based tracer having average dimensions comprised between 20 and 200 nm, detectable by means of one or several S signals at dilutions of less than or equal to 10−7, adapted to form a stable colloidal suspension in a saline medium, at least a portion of which is constituted of a core and a coating provided with an adjustable hydrophilic-lipophilic balance (HLB) and comprising at least one organic and/or organosilicon component; recovering the liquid having diffused; and analyzing this liquid having diffused to measure the quantity of tracer by detection of the signal or signals S.

    摘要翻译： 本发明涉及示踪流体的开发，更一般地说，旨在在储油器中例如从注入井到生产井的压力下注入含水液体。 本发明的目的是提出一种通过所述固体介质通过扩散含有示踪剂的液体（即注射水）的固体介质，即储油器的研究的新方法，所述固体介质易于实施和经济，并且其中 弥补了油藏注射水已知示踪剂的缺点。 该方法基本上包括在该固体培养基中注入含有平均尺寸在20和200nm之间的纳米颗粒型示踪剂的注射液，其可以通过少于或等于10- 7，适于在盐水介质中形成稳定的胶体悬浮液，其至少一部分由芯和具有可调亲水亲油平衡（HLB）的涂层构成，并且包含至少一种有机和/或有机硅组分 ; 回收扩散的液体; 并且通过检测信号或信号S来分析扩散的液体来测量示踪剂的量。