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6 条记录 (耗时 0.019 秒)

    Thionophosphate derivatives, process for their preparation and pharmaceutical compositions containing them
    2.
    发明授权
    Thionophosphate derivatives, process for their preparation and pharmaceutical compositions containing them 失效
    硫代磷酸酯衍生物，其制备方法和含有它们的药物组合物

    公开(公告)号：US06200962B1

    公开(公告)日：2001-03-13

    申请号：US08849122

    申请日：1997-08-07

    申请人： Oren Tirosh ,  Joshua Katzhendler ,  Isaac Ginsburg ,  Yehezkel Barenholz ,  Ron Kohen

    发明人： Oren Tirosh ,  Joshua Katzhendler ,  Isaac Ginsburg ,  Yehezkel Barenholz ,  Ron Kohen

    IPC分类号： A61K31664

    CPC分类号： A61Q17/00 ,  A61K8/55 ,  A61K31/664 ,  A61K2800/522

    摘要： The invention relates to a compound of formula (I) in which X1 and X2 each independently represents an oxygen or nitrogen atom; p,m and n are each independently an integer of at least 2; R, R1 and R2 each independently represents a hydrogen atom; a halogen atom; an optionally substituted straight-chained or branched alkyl alkenyl or alkynyl radical; a group R3O in which R3 is hydrogen atom, an optionally substituted straight-chained or branched alkyl alkenyl or alkynyl radical; optionally substituted acyl or optionally substituted aryl or heteroaryl; a group R4O(O)C in which R4 is a hydrogen atom or an optionally straight-chained or branched alkyl, alkenyl or allkynyl radical; a group —SR5 is a hydrogen atom or an optionally substituted straight-chained or branched alkyl alkenyl or alkynyl radical; a group —NR6R7 in which R6 and R7 each independently represents a hydrogen atom, an optionally substituted straight-chained or branched alkyl, alkenyl or alkynyl radical; optionally substituted acyl; or an optionally substituted phosphate ester group. The invention also relates to processes., for The preparation of compounds of the formula and to pharmaceutical compositions containing the same.

    摘要翻译： 本发明涉及式（I）化合物，其中X 1和X 2各自独立地表示氧或氮原子; p，m和n各自独立地为至少2的整数; R，R 1和R 2各自独立地表示氢原子; 卤素原子; 任选取代的直链或支链烷基烯基或炔基; R 3为氢原子的基团R 3 O，任选取代的直链或支链烷基烯基或炔基; 任选取代的酰基或任选取代的芳基或杂芳基; R 4是氢原子或任选的直链或支链烷基，烯基或全炔基的基团R4O（O）C; 基团-SR 5是氢原子或任选取代的直链或支链烷基烯基或炔基; R 6和R 7各自独立地表示氢原子的基团-NR 6 R 7，任选取代的直链或支链烷基，烯基或炔基; 任选取代的酰基; 或任选取代的磷酸酯基团。 本发明还涉及制备下式化合物和含有该化合物的药物组合物的方法。

    Pentose derivatives as anti-hyperglycemic drugs
    5.
    发明申请
    Pentose derivatives as anti-hyperglycemic drugs 有权
    戊糖衍生物作为抗高血糖药物

    公开(公告)号：US20050277599A1

    公开(公告)日：2005-12-15

    申请号：US11109907

    申请日：2005-04-19

    申请人： Shlomo Sasson ,  Erol Cerasi ,  Arie Gruzman ,  Joshua Katzhendler

    发明人： Shlomo Sasson ,  Erol Cerasi ,  Arie Gruzman ,  Joshua Katzhendler

    IPC分类号： C07H9/04 ,  C07H15/04 ,  C07H15/14 ,  A61K31/70 ,  A61K31/045 ,  C07C31/18

    CPC分类号： C07H9/04 ,  C07H15/04 ,  C07H15/14

    摘要： The present invention relates to pentose and pentose derivatives that are effective at increasing glucose transport in a non-insulin dependent manner, and to uses thereof for a) treating and/or preventing hyperglycemia; b) treating and/or preventing the complications of hyperglycemia; c) treating diabetes; d) increasing the rate of cellular glucose transport; e) increasing the rate of cellular glucose uptake; f) improving the ability of a subject to metabolize glucose; g) treating daily blood glucose fluctuations; h) reducing blood sugar levels; i) reducing the dosage of anti-diabetic medication needed for treatment of diabetes. The present invention further provides novel pentose derivatives having beneficial properties in terms of pharmacokinetics, to pharmaceutical compositions comprising these novel compounds and uses thereof.

    摘要翻译： 本发明涉及以非胰岛素依赖的方式增加葡萄糖转运有效的戊糖和戊糖衍生物及其用于a）治疗和/或预防高血糖症的用途; b）治疗和/或预防高血糖并发症; c）治疗糖尿病; d）增加细胞葡萄糖转运的速率; e）增加细胞葡萄糖摄取的速率; f）提高受试者代谢葡萄糖的能力; g）治疗日常血糖波动; h）降低血糖水平; i）减少治疗糖尿病所需的抗糖尿病药物的剂量。 本发明还提供了在药代动力学方面具有有益性质的新型戊糖衍生物，包含这些新化合物的药物组合物及其用途。

    Pentose derivatives as anti-hyperglycemic drugs
    6.
    发明授权
    Pentose derivatives as anti-hyperglycemic drugs 有权
    戊糖衍生物作为抗高血糖药物

    公开(公告)号：US07812142B2

    公开(公告)日：2010-10-12

    申请号：US11109907

    申请日：2005-04-19

    申请人： Shlomo Sasson ,  Erol Cerasi ,  Arie Gruzman ,  Joshua Katzhendler

    发明人： Shlomo Sasson ,  Erol Cerasi ,  Arie Gruzman ,  Joshua Katzhendler

    IPC分类号： A61K31/7004 ,  A61K31/7008 ,  A61K31/7028 ,  C07H5/06 ,  C07H5/10 ,  C07H9/04 ,  C07H15/04 ,  C07H15/10

    CPC分类号： C07H9/04 ,  C07H15/04 ,  C07H15/14

    摘要： The present invention relates to pentose and pentose derivatives that are effective at increasing glucose transport in a non-insulin dependent manner, and to uses thereof for a) treating and/or preventing hyperglycemia; b) treating and/or preventing the complications of hyperglycemia; c) treating diabetes; d) increasing the rate of cellular glucose transport; e) increasing the rate of cellular glucose uptake; f) improving the ability of a subject to metabolize glucose; g) treating daily blood glucose fluctuations; h) reducing blood sugar levels; i) reducing the dosage of anti-diabetic medication needed for treatment of diabetes. The present invention further provides novel pentose derivatives having beneficial properties in terms of pharmacokinetics, to pharmaceutical compositions comprising these novel compounds and uses thereof.

    摘要翻译： 本发明涉及以非胰岛素依赖的方式增加葡萄糖转运有效的戊糖和戊糖衍生物及其用于a）治疗和/或预防高血糖症的用途; b）治疗和/或预防高血糖并发症; c）治疗糖尿病; d）增加细胞葡萄糖转运的速率; e）增加细胞葡萄糖摄取的速率; f）提高受试者代谢葡萄糖的能力; g）治疗日常血糖波动; h）降低血糖水平; i）减少治疗糖尿病所需的抗糖尿病药物的剂量。 本发明还提供了在药代动力学方面具有有益性质的新型戊糖衍生物，包含这些新化合物的药物组合物及其用途。