公开(公告)号：US5130450A

公开(公告)日：1992-07-14

申请号：US688903

申请日：1991-04-19

申请人： Osamu Kogawa ,  Kenji Iwata ,  Hisao Ekimoto ,  Tadashi Ishii ,  Kimihiko Takada

发明人： Osamu Kogawa ,  Kenji Iwata ,  Hisao Ekimoto ,  Tadashi Ishii ,  Kimihiko Takada

IPC分类号： C07F15/00

CPC分类号： C07F15/0093

摘要： A platinum (II) complex represented by the general formula: ##STR1## [wherein A's are each ammonia or two A's jointly represent 1,2-diaminocyclohexane, 1-amino-1-aminomethylcyclohexane or 1,4-diamino-2-methylbutane; and B's may be same or different and represent ##STR2## (wherein m is 0, 1 or 2; n is 0 or 1; R.sub.1 is a C.sub.3 -C.sub.6 alkyl group substituted with one or two hydroxyl groups) or two B's jointly represent ##STR3## (wherein R.sub.2 is a C.sub.2 -C.sub.5 alkyl group substituted with one hydroxyl group)].These platinum (II) complexes have high potencies for use as an antitumor agent.

公开(公告)号：US5747502A

公开(公告)日：1998-05-05

申请号：US851853

申请日：1992-03-16

申请人： Miyoji Hanaoka ,  Hisao Ekimoto ,  Fumiko Kobayashi ,  Yukio Irie ,  Katsutoshi Takahashi ,  Masanobu Suzuki ,  Takeshi Nakanishi ,  Osamu Kogawa ,  Keizou Ishikawa

发明人： Miyoji Hanaoka ,  Hisao Ekimoto ,  Fumiko Kobayashi ,  Yukio Irie ,  Katsutoshi Takahashi ,  Masanobu Suzuki ,  Takeshi Nakanishi ,  Osamu Kogawa ,  Keizou Ishikawa

IPC分类号： A61K31/473 ,  A61K31/44 ,  C07D471/00

CPC分类号： A61K31/473 ,  Y10S514/883 ,  Y10S514/908

摘要： The present invention relates to benzo�c!phenanthridinium derivative of the general formula A: ##STR1## wherein M and N individually represent a hydroxyl or lower alkoxy group, or M and N simultaneously represent a hydrogen atom or together form a methylenedioxy group, X.sup.- represents an acid residue or a hydrogen acid residue, and R represents a lower alkyl group, and a process for preparing such derivatives. The compounds exhibit both potent antitumor activity and platelet aggregation inhibition activity, and are expected to be useful for the treatment of tumors. The process has good reproducibility and may be effected under moderate conditions, and therefore the process is practically useful. In addition, hydrogen salts of the present compounds have an enhanced stability, which is an advantage in formulating the same into pharmaceutical preparations.

摘要翻译： 本发明涉及通式A的苯并[c]菲啶鎓衍生物：其中M和N各自表示羟基或低级烷氧基，或M和N同时代表氢原子或一起形成亚甲二氧基 基团，X-表示酸残基或氢酸残基，R表示低级烷基，以及制备该衍生物的方法。 该化合物表现出有效的抗肿瘤活性和血小板聚集抑制活性，并且预期可用于治疗肿瘤。 该方法具有良好的再现性并且可以在中等条件下进行，因此该方法实际上是有用的。 此外，本发明化合物的氢盐具有增强的稳定性，这将其配制成药物制剂是有利的。

公开(公告)号：US06251355B1

公开(公告)日：2001-06-26

申请号：US09319837

申请日：1999-06-10

申请人： Toshitaka Murata ,  Keizou Ishikawa ,  Osamu Kogawa ,  Kenji Iwata

发明人： Toshitaka Murata ,  Keizou Ishikawa ,  Osamu Kogawa ,  Kenji Iwata

IPC分类号： C01B2100

CPC分类号： C01G55/002 ,  A61K9/14 ,  A61K33/24 ,  C01P2002/72 ,  C01P2002/74 ,  C01P2004/03

摘要： The present invention relates to a novel fine cisplatin powder utilized as an anticancer agent. The fine cisplatin powder obtained in the present invention does not cause secondary agglomeration, is excellent in fluidity and easily handleable in the pharmaceutical preparation step. Furthermore, the fine cisplatin powder is reduced in the content of N,N-dimethylformamide as the residual solvent, and can be dissolved rapidly in physiological saline, thus being suitable for cancer therapy particularly by intra-arterial injection. This fine powder can be produced by contriving specified means for crystallizing cisplatin from a solution thereof in N,N-dimethylformamide.

摘要翻译： 本发明涉及用作抗癌剂的新颖的顺铂铂粉。 本发明得到的细顺铂粉末不会引起二次凝聚，流动性优异，药物制备工序容易操作。 此外，顺铂的细粉末作为残留溶剂的N，N-二甲基甲酰胺的含量降低，能够迅速溶解于生理盐水中，因此特别适用于动脉内注射的癌症治疗。 这种细粉末可以通过设计用于在N，N-二甲基甲酰胺中从其溶液中结晶顺铂的特定方法来制备。