摘要:
The present invention relates to benzo�c!phenanthridinium derivative of the general formula A: ##STR1## wherein M and N individually represent a hydroxyl or lower alkoxy group, or M and N simultaneously represent a hydrogen atom or together form a methylenedioxy group, X.sup.- represents an acid residue or a hydrogen acid residue, and R represents a lower alkyl group, and a process for preparing such derivatives. The compounds exhibit both potent antitumor activity and platelet aggregation inhibition activity, and are expected to be useful for the treatment of tumors. The process has good reproducibility and may be effected under moderate conditions, and therefore the process is practically useful. In addition, hydrogen salts of the present compounds have an enhanced stability, which is an advantage in formulating the same into pharmaceutical preparations.
摘要:
This invention relates to the novel selenium compounds which are useful as an antineoplastic agent. The compounds are represented by the general formula (I):Se(O).sub.a (R).sub.b (X).sub.c (A).sub.n (Y).sub.m (I)wherein R, X, A and Y represent the groups specified below, a represents a number of 0 or 1, b represents a number of 0, 1 or 2, and (1) when a is 0 and b is also 0, c is 4, n is 1 or 2 and m is 0, (2) when a is 1 and b is 0, c is 2, n is 1 or 2 and m is 0 or 1, and (3) when b is 1 or 2, c, n and m are all 0;(i) when b is 2, R represents (1) a C.sub.4-10 alkoxy group substituted with a halogen atom, (2) a lower alkoxyl group substituted with a halogen atom and a phenyl group, or (3) a cycloalkyloxy group substituted with a halogen atom, and (ii) when b is 1, R represents a group represented by the formula ##STR1## (wherein R.sub.0 is a C.sub.2-6 alkyl group); X represents a halogen atom;A represents a compound represented by the formula ##STR2## (wherein R.sub.1 and R.sub.2 may be the same or different and represent a hydrogen atom, a hydroxyl group, a lower alkyl group, a halogen atom, a phenyl group, a cyano group, a lower alkoxycarbonly group, a phenoxycarbonyl group, an amino group (to which a lower alkyl, lower alkylaminocarbonyl, lower halogenoalkylaminocarbonyl or lower alkoxycarbonyl group may be bonded), a benzoyl group, a loweralkoxyl group, a carbamyl group or an allyloxycarbonyl group; R.sub.7 represents a hydrogen atom, a lower alkyl group or a group represented by the formula ##STR3## (wherein R.sub.9 represents an amino group or a lowr alkoxyl group); Y represents H.sub.2 O.
摘要:
A process for purification which permits satisfactory removal of impurities from a block copolymer consisting essentially of polyethylene glycols and poly(acidic amino acid) and is suitable for the production of a polymeric carrier having a pharmaceutically acceptable purity; a process for producing such a polymeric carrier; a block copolymer reduced in impurity content; a polymeric carrier as described above; pharmaceutical preparations in polymeric form, produced by the use of the carrier; and a method of subjecting polyethylene glycols and poly(acidic amino acids)—which are impurities contained in the block copolymer—to treatment with either an ion-exchange resin or a partition/absorption resin and then determining the quantities of them with a gel filtration column.
摘要:
An installation apparatus is comprised of a pair of grasping brackets and an installation jig. The installation apparatus is employed to install a cockpit module in a vehicle body in a manner that the grasping brackets is detachably attached respectively to both end portions of a steering member of the cockpit module and that the installation jig grasps the grasping brackets and conveys the cockpit module to the vehicle body.
摘要:
An installation apparatus is comprised of a pair of grasping brackets and an installation jig. The installation apparatus is employed to install a cockpit module in a vehicle body in a manner that the grasping brackets is detachably attached respectively to both end portions of a steering member of the cockpit module and that the installation jig grasps the grasping brackets and conveys the cockpit module to the vehicle body.
摘要:
A frequency converter for use in a 4 GHz-band comprising a printed circuit board and a shield case. The printed circuit board is provided in the shield case and composed of an input terminal, and successively, a circuit of low noise amplifier, a band pass filter, a mixer and a circuit of local oscillator connected to the mixer. The constitution of the frequency converter is simplified, and accordingly the mass productivity, yield of production and reliability of the fabricated converter are greatly improved.
摘要:
A joint to be attached to a port of a micro fluidic element, has an outer peripheral surface of truncated subulate shape at a front end portion of the joint to form a front surface as a top of the truncated subulate shape, and a cuneiform space in an inside of the joint at the front end portion of the joint, the joint is made of an elastomer, and the cuneiform space includes a front end overlapping the front surface as seen in a direction along which a tube is guided by the cuneiform space when the tube is inserted into the joint so that the tube is enabled to penetrate the front surface through the front end.
摘要:
A carrying apparatus for carrying an automobile dash module to an interior of a vehicle includes a support portion, a sliding part, and a fixing part. The support portion is configured and adapted to carry the dash module into the interior of the vehicle through a door opening of a vehicle body. The support portion includes a main frame that extends in a direction that is substantially parallel to a direction of a length of the dash module supported by the support portion. The sliding part is slidably coupled to the main frame to slide in the longitudinal direction of the main frame. The fixing part is configured and adapted to be fixed to a predetermined portion of a periphery of the door opening. The fixing part is coupled to the sliding part and configured to engage a portion of the vehicle body so that the main frame and said sliding part can pivot about an axis oriented in a vertical direction relative to the vehicle body. With the carrying apparatus of the present invention, it is easy to carry a dash module having various components surrounding a dash into the interior of a vehicle, even after doors are attached to the vehicle body.
摘要:
A filter has a plurality of resonators formed regularly on a substrate and made of a superconducting material. In measuring resonance frequency of the resonators, the filter and a conductive metal plate having an opening are placed in a vacuum chamber so that all the resonators other than one resonator which faces the opening are covered with the metal plate. The metal plate has an input probe and an output probe at the opening of the metal plate. The resonance frequency of each resonator is measured in sequence while rotating the metal plate. Each resonator is adjusted in shape by a laser trimming or providing a dielectric film in correspondence with the measured resonance frequency so that all the resonators have a fixed resonance frequency.