公开(公告)号：US5747502A

公开(公告)日：1998-05-05

申请号：US851853

申请日：1992-03-16

申请人： Miyoji Hanaoka ,  Hisao Ekimoto ,  Fumiko Kobayashi ,  Yukio Irie ,  Katsutoshi Takahashi ,  Masanobu Suzuki ,  Takeshi Nakanishi ,  Osamu Kogawa ,  Keizou Ishikawa

发明人： Miyoji Hanaoka ,  Hisao Ekimoto ,  Fumiko Kobayashi ,  Yukio Irie ,  Katsutoshi Takahashi ,  Masanobu Suzuki ,  Takeshi Nakanishi ,  Osamu Kogawa ,  Keizou Ishikawa

IPC分类号： A61K31/473 ,  A61K31/44 ,  C07D471/00

CPC分类号： A61K31/473 ,  Y10S514/883 ,  Y10S514/908

摘要： The present invention relates to benzo�c!phenanthridinium derivative of the general formula A: ##STR1## wherein M and N individually represent a hydroxyl or lower alkoxy group, or M and N simultaneously represent a hydrogen atom or together form a methylenedioxy group, X.sup.- represents an acid residue or a hydrogen acid residue, and R represents a lower alkyl group, and a process for preparing such derivatives. The compounds exhibit both potent antitumor activity and platelet aggregation inhibition activity, and are expected to be useful for the treatment of tumors. The process has good reproducibility and may be effected under moderate conditions, and therefore the process is practically useful. In addition, hydrogen salts of the present compounds have an enhanced stability, which is an advantage in formulating the same into pharmaceutical preparations.

摘要翻译： 本发明涉及通式A的苯并[c]菲啶鎓衍生物：其中M和N各自表示羟基或低级烷氧基，或M和N同时代表氢原子或一起形成亚甲二氧基 基团，X-表示酸残基或氢酸残基，R表示低级烷基，以及制备该衍生物的方法。 该化合物表现出有效的抗肿瘤活性和血小板聚集抑制活性，并且预期可用于治疗肿瘤。 该方法具有良好的再现性并且可以在中等条件下进行，因此该方法实际上是有用的。 此外，本发明化合物的氢盐具有增强的稳定性，这将其配制成药物制剂是有利的。

公开(公告)号：US4952409A

公开(公告)日：1990-08-28

申请号：US352752

申请日：1989-05-16

申请人： Ko Bando ,  Yoshimasa Senoo ,  Minoru Noji ,  Kazuo Ootsuki ,  Hisao Ekimoto ,  Yukio Irie

发明人： Ko Bando ,  Yoshimasa Senoo ,  Minoru Noji ,  Kazuo Ootsuki ,  Hisao Ekimoto ,  Yukio Irie

IPC分类号： A01N1/02 ,  A61K9/127 ,  A61K38/44 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10

CPC分类号： A61K38/446 ,  A61K9/127 ,  Y10S436/829

摘要： Disclosed is an agent for prevention and remedy of injuries caused by ischemia, which comprises, as an active ingredient, an SOD-containing liposome comprising a superoxidase dismutase (SOD) retained in a liposome having an electrically neutral or negative membrane.

公开(公告)号：US06385344B2

公开(公告)日：2002-05-07

申请号：US09075534

申请日：1998-05-11

申请人： Yukio Irie ,  Shinya Okada ,  Aya Nakadai ,  Yoshiyuki Okada

发明人： Yukio Irie ,  Shinya Okada ,  Aya Nakadai ,  Yoshiyuki Okada

IPC分类号： G06K936

CPC分类号： H04N1/405

摘要： An operator can select image processing for a half tone image area among a plurality of processing methods, and image processing appropriate for the image can be carried out thereby. An original image is read by an image sensor 1 and output through either simple binary conversion by binary conversion means 3 for character processing or half tone image processing by binary conversion means 2 for photograph processing. Judging means 6 judges whether image data are of a character image area or a half tone image area, and switches output between the binary conversion means 3 for character processing and the binary conversion means 2 for photograph processing. The binary conversion means 2 for photograph processing includes error diffusion processing means 10 and dither processing means 11. By setting of setting means 13 carried out by an operator, output from either the error diffusion processing means 10 or the dither processing means 11 is selected for a half tone image.

摘要翻译： 操作员可以在多种处理方法中选择半色调图像区域的图像处理，从而可以执行适合于图像的图像处理。 原始图像由图像传感器1读取，并通过用于字符处理的二进制转换装置3的简单二进制转换或用于照片处理的二进制转换装置2的半色调图像处理来输出。 判断装置6判断图像数据是字符图像区域还是半色调图像区域，并且切换用于字符处理的二进制转换装置3和用于照片处理的二进制转换装置2之间的输出。 用于照片处理的二进制转换装置2包括误差扩散处理装置10和抖动处理装置11.通过设置由操作者进行的设定装置13，选择从误差扩散处理装置10或抖动处理装置11输出的 半色调图像。

公开(公告)号：US06460454B1

公开(公告)日：2002-10-08

申请号：US09413587

申请日：1999-10-06

申请人： Hikaru Oike ,  Yukio Irie

发明人： Hikaru Oike ,  Yukio Irie

IPC分类号： B41C114

CPC分类号： B41J2/32 ,  B41J3/24 ,  B41J2202/32

摘要： A heat-sensitive stencil master making system includes a thermal head having an array of a number of heater elements which extends in a main scanning direction substantially perpendicular to a sub-scanning direction in which the thermal head is moved relatively to heat-sensitive stencil master material when imagewise perforating the heat-sensitive stencil master material. Each of the heater elements is longer in the main scanning direction than in the sub-scanning direction.

摘要翻译： 热敏模版母版制作系统包括具有多个加热器元件的阵列的热敏头，所述加热器元件在主扫描方向上延伸，所述主扫描方向基本上垂直于热敏头相对于热敏模板母头的副扫描方向垂直 成像时穿透热敏模板母材的材料。 每个加热元件在主扫描方向上比在副扫描方向上更长。

公开(公告)号：US06357348B1

公开(公告)日：2002-03-19

申请号：US09441780

申请日：1999-11-17

申请人： Jun Nakamura ,  Hideyuki Kinoshita ,  Yukio Irie ,  Kunio Nomura ,  Atsushi Takata ,  Shinichi Takizawa ,  Yoshiyuki Okada ,  Hikaru Oike

发明人： Jun Nakamura ,  Hideyuki Kinoshita ,  Yukio Irie ,  Kunio Nomura ,  Atsushi Takata ,  Shinichi Takizawa ,  Yoshiyuki Okada ,  Hikaru Oike

IPC分类号： B41J237

CPC分类号： B41J2/3555 ,  B41J2/32 ,  B41J2/38 ,  B41J2202/32

摘要： A heat-sensitive stencil master making apparatus for making a stencil master by imagewise perforating thermoplastic film of heat-sensitive stencil master material according to an image on an original includes a thermal head which has an array of a plurality of heater elements and is brought into thermal contact with the thermoplastic film. Heater elements selected from the array of the heater elements according to the image on the original are applied with an electric voltage so that perforations are formed in the parts of the thermoplastic film of the heat-sensitive stencil master material in contact with the selected heater elements. A continuous electric voltage is applied to each of the selected heater elements to heat the heater element to a predetermined temperature in a predetermined temperature range adequate to thermally perforate the thermoplastic film and then an intermittent electric voltage is applied to the heater element so that the temperature of the heater element is held in the predetermined temperature range for a predetermined time interval adequate to thermally perforate the thermoplastic film.

摘要翻译： 根据原稿上的图像，通过对热敏蜡纸母材的热塑性薄膜进行成像穿孔来制造模版母版的热敏模版母版制作装置包括具有多个加热器元件的阵列的热敏头， 与热塑性薄膜热接触。 根据原稿上的图像从加热器元件的阵列中选择的加热元件被施加电压，使得在热敏模版母材的热塑性膜的部分中形成穿孔，所述部分与所选择的加热器元件接触 。 对每个所选择的加热器元件施加连续的电压，以将加热器元件加热到预定的温度范围，该预定温度足以使热塑性膜热穿孔，然后将间歇电压施加到加热器元件，使得温度 的加热元件在预定温度范围内保持足以使热塑性薄膜热穿孔的预定时间间隔。

公开(公告)号：US06359702B1

公开(公告)日：2002-03-19

申请号：US09076103

申请日：1998-05-12

申请人： Yukio Irie ,  Shinya Okada ,  Yoshiyuki Okada

发明人： Yukio Irie ,  Shinya Okada ,  Yoshiyuki Okada

IPC分类号： H04N138

CPC分类号： H04N1/38

摘要： Image data for a margin around the image area of a book form original can be erased and image data for a book center portion are obtained without loss. In a photograph mode, a low threshold value is set in first binary conversion means 4, and image data having been input are binary converted by using this value. Based on the image data having been converted, a first coercion signal generating unit 6 judges a margin around the original image. A high threshold value is set to second binary conversion means 5 and image data having been input are binary converted by using this value. Based on the image data having been converted, a second coercion signal generating unit 7 judges a margin around the original and a portion including a book center portion. A character processing binary conversion unit 3 carries out binary conversion on input image data for the portion within the original, and outputs whitening data which erase the margin around the original. A photograph processing binary conversion unit 2 carries out tone image binary conversion only on the book center portion in the input image data and outputs the data thereof. An image processing selecting unit 10 makes the image data for the portion within the original image selectively output from the character processing binary conversion unit 3 and makes the image data for the book center portion selectively output from the photograph processing binary conversion unit 2.

摘要翻译： 可以擦除书本原稿的图像区域周围的边缘的图像数据，并且不损失地获得书中心部分的图像数据。 在照片模式中，在第一二进制转换装置4中设置低阈值，并且通过使用该值对输入的图像数据进行二进制转换。 基于已经转换的图像数据，第一强制信号生成单元6判断原始图像周围的边缘。 将高阈值设置为第二二进制转换装置5，并且已经输入的图像数据通过使用该值进行二进制转换。 基于已经转换的图像数据，第二强制信号生成单元7判断原稿周围的边缘和包括书本中心部分的部分。 字符处理二进制转换单元3对原稿内的部分的输入图像数据进行二进制转换，并输出消除原稿周围边缘的白化数据。 照片处理二进制转换单元2仅在输入图像数据中的书中心部分执行音调图像二进制转换，并输出其数据。 图像处理选择单元10使得从图像处理二进制转换单元3选择性地输出原始图像内的部分的图像数据，并且从照片处理二进制转换单元2中选择性地输出书本中心部分的图像数据。

公开(公告)号：US06330012B1

公开(公告)日：2001-12-11

申请号：US09312953

申请日：1999-05-17

申请人： Yukio Irie

发明人： Yukio Irie

IPC分类号： B41J2365

CPC分类号： B41J2/3551

摘要： An image forming system includes a thermal head having a linear array of a plurality of heater elements extending in a direction of the main scanning, and a head driver which drives the thermal head on the basis of image data to selectively operate the respective heater elements according to image data while the thermal head is being moved relative to a recording medium in a direction of the sub-scanning, thereby forming a copy of the image represented by the image data on the recording medium line by line. The heater elements are divided into a plurality of head blocks which are contiguous in the main scanning direction, and the head driver is provided with a plurality of head drive segments of the same number as the number of the head blocks. Image data consisting of a plurality of pieces of line image data is stored in a memory. Each line image data consists of a plurality of image data fractions which are of the same number as the number of the head drive segments. When contiguous multi-imaging is to be carried out, the image data fraction of each of the pieces of line image data corresponding to the part to be multiplied of the image is input into the head drive segments which drive the head blocks corresponding to the positions where the copies are to be formed.

摘要翻译： 图像形成系统包括具有沿主扫描方向延伸的多个加热器元件的线性阵列的热敏头，以及基于图像数据驱动热敏头的头驱动器，以根据图像数据选择性地操作各加热器元件， 在热敏头相对于记录介质在副扫描的方向上移动时对图像数据进行成像，从而逐行地在记录介质上形成由图像数据表示的图像的副本。 加热器元件被分成在主扫描方向上相邻的多个头块，并且头驱动器设置有与头块数相同数量的多个头驱动段。 由多条线图像数据构成的图像数据被存储在存储器中。 每个行图像数据由与头驱动段的数量相同数目的多个图像数据分数组成。 当要执行连续的多成像时，将与图像相乘的部分相对应的每条行图像数据的图像数据分数输入到驱动与位置对应的头部块的磁头驱动段中 将要复印的地方。