公开(公告)号：US06420171B1

公开(公告)日：2002-07-16

申请号：US09549493

申请日：2000-04-14

申请人： Osamu Nakamura ,  Hideki Ohba ,  Imre Sallay ,  Fumio Yagi ,  Sawako Moriwaki ,  Seiji Yasuda

发明人： Osamu Nakamura ,  Hideki Ohba ,  Imre Sallay ,  Fumio Yagi ,  Sawako Moriwaki ,  Seiji Yasuda

IPC分类号： C12N506

CPC分类号： C12N5/0093 ,  A61M1/3679 ,  A61M2202/0439 ,  C07K14/37 ,  C07K14/42 ,  C07K17/10 ,  Y10S530/812 ,  Y10S530/813

摘要： An efficient method for therapeutic treatment of leukemia is provided in which a patient's body fluid during external circulation is brought into direct contact with an adsorbent material capable of specifically and selectively adsorbing leukemic cells in the body fluid. The leukemic cell-adsorbing material is a composite of a lectin protein coupled with a physiologically inert carrier material such as a galactan polysaccharide in the form of beads. The lectin protein may be obtained from a mushroom fungus such as Agrocybe cylindracea or a leguminous seed such as from the jequirity bean plant. The lectin protein and carrier material can be bound by forming chemical linkages between amino groups in the lectin protein and functional groups in the carrier material, and unreacted functional groups of the carrier material may be blocked with an amino acid. A leukemic cell-adsorbing column may be formed by filling the leukemic cell-adsorbing material into a tubular body to form an adsorbent bed. The tubular body may have an inner diameter of from 10 to 20 mm and a height of from 50 to 200 mm.

摘要翻译： 提供了一种治疗白血病的有效方法，其中外部循环期间的患者体液与能够特异性和选择性地吸收体液中的白血病细胞的吸附材料直接接触。 白血病细胞吸附材料是凝集素蛋白与生理惰性载体材料如珠粒形式的半乳聚糖多糖的复合物。 凝集素蛋白质可以从蘑菇真菌如花椰菜（Agrocybe cylindracea）或豆科植物种子（例如来自不育豆）得到。 凝集素蛋白质和载体材料可以通过在凝集素蛋白中的氨基和载体材料中的官能团之间形成化学键而结合，载体材料的未反应的官能团可以用氨基酸封闭。 可以通过将白血病细胞吸附材料填充到管状体中以形成吸附床来形成白血病细胞吸附柱。 管状体的内径可以为10〜20mm，高度为50〜200mm。

公开(公告)号：US06987022B2

公开(公告)日：2006-01-17

申请号：US10158157

申请日：2002-05-31

申请人： Osamu Nakamura ,  Hideki Ohba ,  Imre Sallay ,  Fumio Yagi ,  Sawako Moriwaki ,  Seiji Yasuda

发明人： Osamu Nakamura ,  Hideki Ohba ,  Imre Sallay ,  Fumio Yagi ,  Sawako Moriwaki ,  Seiji Yasuda

IPC分类号： C12N5/06 ,  C12N5/08 ,  C12N11/10 ,  C07K17/02 ,  C07K17/10

CPC分类号： C12N5/0093 ,  A61M1/3679 ,  A61M2202/0439 ,  C07K14/37 ,  C07K14/42 ,  C07K17/10 ,  C12N5/0694 ,  Y10S530/812 ,  Y10S530/813

摘要： An efficient method for therapeutic treatment of a leukemic patient is disclosed in which the patient's body fluid under external circulation is brought into direct contact with an adsorbent material capable of adsorbing the leukemic cells in the body fluid specifically and selectively. The leukemic cell-adsorbent material, which is used by filling a column to form an adsorbent bed, is a conjugate of a lectin protein extracted from, e.g., Dolichos beans or soybeans coupled with a physiologically inert carrier material such as a polysaccharide in the form of beads or a superparamagnetic material in the form of iron oxide-based magnetic beads.

摘要翻译： 公开了一种用于治疗白血病患者的有效方法，其中将外部循环下的患者体液与能够特异性且选择性地吸收体液中的白血病细胞的吸附材料直接接触。 用于填充柱以形成吸附床的白血病细胞吸附材料是从例如Dolichos豆或大豆与生理惰性载体材料如多糖形式的提取的凝集素蛋白的缀合物，其形式为 的珠子或以铁氧化物基磁珠形式的超顺磁性材料。

公开(公告)号：US5072766A

公开(公告)日：1991-12-17

申请号：US637037

申请日：1991-01-03

申请人： Kohichi Kondoh ,  Fumio Yagi

发明人： Kohichi Kondoh ,  Fumio Yagi

IPC分类号： E06B9/06

CPC分类号： E06B9/0676 ,  E06B9/0638

摘要： In a panel shutter assembly including a plurality of shutter panels which are movable up and down along a pair of transversely spaced upstanding guide rails, a pair of chains to which the panels are fastened one after another, a set of sprockets engaging the chains for moving the chains in either direction to move the panels to open and close a shutter opening, and a pair of panel supporting rails from which the panels are suspended in a panel storage space when the shutter opening is opened, the sprockets consist of a pair of first sprockets for moving the panels up and down and a pair of sound sprockets spaced horizontally apart from the first sprockets and provided between the first sprockets and the panel storage space for moving the panels horizontally, and the panel supporting rails extend horizontally. The horizontal supporting rails enable a reduction in height of a box defining the panel storage space. A guide plate or plates can be provided in the box for holding each chain to ensure its horizontal movement between one of the first sprockets and one of the second sprockets and thereby the smooth movement of the panels in the box. Each of the second sprockets can be formed between the roots of every two adjoining teeth thereof with a semicircular recess in which the link pins of the corresponding chain are engageable, so that the chain leaving the second sprocket for the panel storage space may form a U-shaped sag to ensure that all the panels to properly retracted into the panel storage space.

摘要翻译： 在包括可沿着一对横向间隔开的直立导轨上下移动的多个快门面板的面板快门组件中，一对链条，面板一个接一个地紧固到该一对链条上，一组链轮接合链条以移动 链条沿任一方向移动以打开和关闭快门开口的面板，以及一对面板支撑轨道，当开闭器开口打开时，面板将板悬挂在面板存储空间中，链轮由一对第一 用于使面板上下移动的链轮和一对与第一链轮水平隔开的声音链轮，并且设置在第一链轮和面板存储空间之间，用于水平移动面板，并且面板支撑轨水平地延伸。 水平支撑导轨能够减小限定面板存储空间的盒子的高度。 可以在箱中设置导向板或板，用于保持每个链条，以确保其在第一链轮中的一个与第二链轮中的一个之间的水平运动，从而使板在箱中的平滑运动。 每个第二链轮可以在其每两个邻接的齿的根部之间形成有半圆形凹槽，其中相应链条的连杆销可接合，使得离开用于面板存储空间的第二链轮的链条可以形成U 形下垂，以确保所有面板正确收回到面板存储空间。