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    Method and apparatus for controlling carbon source concentration in aerobic cultivation of a microorganism
    2.
    发明授权
    Method and apparatus for controlling carbon source concentration in aerobic cultivation of a microorganism 失效
    用于控制微生物需氧培养中碳源浓度的方法和装置

    公开(公告)号：US5912113A

    公开(公告)日：1999-06-15

    申请号：US905713

    申请日：1997-08-04

    申请人： Takashi Nakamura ,  Tatsuya Nakayama ,  Yosuke Koyama ,  Keishi Shimazaki ,  Harufumi Miwa ,  Minoru Tsuruta ,  Koji Tamura ,  Osamu Tosaka

    发明人： Takashi Nakamura ,  Tatsuya Nakayama ,  Yosuke Koyama ,  Keishi Shimazaki ,  Harufumi Miwa ,  Minoru Tsuruta ,  Koji Tamura ,  Osamu Tosaka

    IPC分类号： C12M1/36 ,  C12N1/20 ,  C12P1/00 ,  C12P13/06 ,  C12P13/08 ,  C12Q3/00 ,  C12N1/12 ,  C12N1/14

    CPC分类号： C12M41/32 ,  C12M41/26 ,  C12M41/34 ,  C12M41/48 ,  C12N1/20 ,  C12P13/08 ,  Y10S435/822 ,  Y10S435/948

    摘要： The present invention is a method for aerobically cultivating yeast or bacteria in a culture medium of fed-batch, continuous or cell-recycling continuous cultures, wherein the carbon source concentration in the culture medium is maintained at a constant low level of under g/l. The carbon source concentration is maintained by measuring the carbon consumption of a culture of the yeast or bacteria in a preliminary experiment. The rate is determined between the time the culture is started and a time when the carbon source is exhausted. A feeding time is then determined wherein the activity of the yeast or bacteria in the presence of the carbon source does not change and a volume of the carbon source to be used in a first feeding (So) is set as So=.nu..times.T. Then, in a main culture, a first feeding of a volume of the carbon source (So) is added for the time (T), and the exhaustion of the carbon source is detected as an increase in pH or an increase in concentration of oxygen dissolved in the culture medium. A second feeding of a volume of the carbon source is then added for the time (T), and the feeding rate is determined based on a period (.tau.) before which the second feeding is added as follows:if 10 min..gtoreq..tau., the feeding rate of the feed solution is set at 1.1.times..nu.;if 30 min..gtoreq..tau.>10 min., the feeding rate of the feed solution is set at .nu.;if 60 min..gtoreq..tau.>30 min., the feeding rate is set at 0.9.times..nu.; orif 120 min..gtoreq..tau.>60 min., the feeding rate is set at 0.8.times..nu.. By modifying the feeding rate in this way, the carbon source concentration in the cultivation vessel is kept at the constant low level of under 5 g/l.

    摘要翻译： 本发明是在补料分批，连续或细胞循环连续培养的培养基中有氧培养酵母或细菌的方法，其中培养基中的碳源浓度保持在低于g / l的恒定低水平 。 通过在初步实验中测量酵母或细菌的培养物的碳消耗来维持碳源浓度。 速率是在文化开始时间和碳源耗尽时间之间确定的。 然后确定进料时间，其中在碳源存在下酵母或细菌的活性不变，并且在第一次进料（So）中使用的碳源的体积被设定为So = nu xT。 然后，在主培养中，在时间（T）下加入体积的碳源（So）的第一次进料，并且随着pH的增加或氧浓度的增加检测碳源的耗尽 溶解在培养基中。 然后在时间（T）下加入体积的碳源的第二次进料，并且基于如下加入第二次进料的时间段（τ）确定进料速率：如果10分钟> / = tau，进料溶液的进料速率设定为1.1×nu; 如果30分钟，则进料溶液的进料速度设定为nu; 如果60分钟> 30分钟，进料速率设定为0.9x nu; 或者如果120分钟，则进料速率设定为0.8x nu。 通过以这种方式改变进料速率，培养容器中的碳源浓度保持在5g / l以下的恒定低水平。

    Workflow system, workflow control method and storage medium
    3.
    发明授权
    Workflow system, workflow control method and storage medium 失效
    工作流系统，工作流控制方法和存储介质

    公开(公告)号：US06853974B1

    公开(公告)日：2005-02-08

    申请号：US09377402

    申请日：1999-08-20

    申请人： Shunsuke Akifuji ,  Toshiaki Sakaguchi ,  Yoko Seki ,  Masato Tamaki ,  Atsushi Aoki ,  Yoshiki Matsuda ,  Osamu Tosaka ,  Shigeki Ishihara

    发明人： Shunsuke Akifuji ,  Toshiaki Sakaguchi ,  Yoko Seki ,  Masato Tamaki ,  Atsushi Aoki ,  Yoshiki Matsuda ,  Osamu Tosaka ,  Shigeki Ishihara

    IPC分类号： G06Q10/10 ,  G06F17/60

    CPC分类号： G06Q10/10 ,  G06Q10/06316 ,  G06Q10/0639

    摘要： In a workflow system capable of simultaneously executing a plurality of business processes, an exception handling unit extracts an exception condition from a business status definition table and transfers the exception condition to a status watcher, the status watcher refers to data contained in an application data base and, when there is a change meeting a predetermined exception condition, transfers the change to a user retrieval unit, the user retrieval unit refers to a working data base to retrieve a user and gives information to the computer of the related user, whereby, when one of interdependent business processes is discontinued, information that the business process is discontinued is given to the computers executing the other interdependent business processes.

    摘要翻译： 在能够同时执行多个业务处理的工作流系统中，异常处理单元从业务状态定义表中提取异常条件，并将异常状况转发给状态监视器，状态监视器参照包含在应用数据库中的数据 并且当满足预定异常条件的变化时，将改变传送到用户检索单元，用户检索单元参考工作数据库以检索用户并向相关用户的计算机提供信息，由此当 一个相互依赖的业务流程被停止，业务流程停止的信息被给予执行其他相互依赖的业务流程的计算机。