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公开(公告)号:US12104022B2
公开(公告)日:2024-10-01
申请号:US17267156
申请日:2019-04-09
Applicant: PEKING UNIVERSITY
Inventor: Xinhua Wan , Xichong Ye , Bowen Li , Jie Zhang
IPC: C08J3/215 , B03C1/005 , B03C1/01 , B03C1/015 , B03C1/02 , B03C1/035 , B03C1/28 , B82Y30/00 , C07B57/00 , C07C227/34 , C07C231/20 , C07C231/24 , C08F212/08 , C08F220/56 , C08F220/58 , C08F293/00 , C08J3/24 , C08K3/22 , C08K5/09 , C08K9/10 , B82Y25/00 , B82Y40/00 , C07C237/06 , C08F220/60
CPC classification number: C08J3/215 , B03C1/005 , B03C1/01 , B03C1/015 , B03C1/02 , B03C1/035 , B03C1/286 , C07B57/00 , C07C227/34 , C07C231/20 , C07C231/24 , C08F212/08 , C08F220/56 , C08F220/58 , C08F293/005 , C08J3/245 , C08K3/22 , C08K5/09 , C08K9/10 , B03C2201/18 , B03C2201/26 , B82Y25/00 , B82Y30/00 , B82Y40/00 , C07B2200/07 , C07C237/06 , C08F220/603 , C08F2438/03 , C08J2325/08 , C08K2003/2275 , C08K2201/003 , C08K2201/01 , C08K2201/011 , C07C227/34 , C07C229/36 , C07C227/34 , C07C229/22 , C07C231/20 , C07C237/06
Abstract: A core-shell nanocomposite is formed by co-assembly of an amphiphilic polymer and hydrophobically modified magnetic nanoparticles, with its core being a hydrophobically modified magnetic nanomaterial and its shell being the amphiphilic polymer, wherein hydrophilic segments in the amphiphilic polymer are located at an outermost layer of the shell. The above composite can be used as additives in the crystallization of conglomerates and obtain optically pure crystals of both enantiomers in a single process. The key thereof is that the composite is used to enrich molecules with the same configuration while inhibit the crystallization of the other enantiomer in a supersaturated solution of conglomerates, such that a non-magnetic crystal and a magnetic crystal (which are enantiomers of each other) are generated in a unit operation. Optically pure crystals of both enantiomers with over 90 ee % can be obtained by one-time crystallization, and the total yield can be as high as 40%.