公开(公告)号：US20180185498A1

公开(公告)日：2018-07-05

申请号：US15690157

申请日：2017-08-29

Applicant: Pharosgen Co., Ltd.

Inventor： Sang-Yoon KIM ,  Youngro Byun ,  Seung Woo Chung

IPC: A61K47/55

CPC classification number: A61K47/551 ,  A61B18/02 ,  A61K31/337 ,  A61K31/65 ,  A61K38/14 ,  A61K45/06 ,  A61K47/542 ,  A61K47/545 ,  A61K47/60 ,  A61K47/61 ,  A61K47/643 ,  A61K47/65 ,  A61N1/403 ,  A61N5/062 ,  A61N7/02 ,  A61N2005/067 ,  A61N2007/0004

Abstract: Described are prodrug conjugates that release a chemotherapeutic agent upon activation by caspase, and methods using such prodrug conjugates to induce apoptosis, amplify apoptosis, and treat cancer.

公开(公告)号：US09775914B2

公开(公告)日：2017-10-03

申请号：US14796219

申请日：2015-07-10

Applicant: PHAROSGEN CO., LTD.

Inventor： Sang-Yoon Kim ,  Youngro Byun ,  Seung Woo Chung

IPC: A61K47/48 ,  A61K31/65 ,  A61K31/337 ,  A61K45/06 ,  A61N1/40 ,  A61K38/14 ,  A61B18/02 ,  A61N7/00 ,  A61N5/067 ,  A61N5/06 ,  A61N7/02

CPC classification number: A61K47/551 ,  A61B18/02 ,  A61K31/337 ,  A61K31/65 ,  A61K38/14 ,  A61K45/06 ,  A61K47/542 ,  A61K47/545 ,  A61K47/60 ,  A61K47/61 ,  A61K47/643 ,  A61K47/65 ,  A61N1/403 ,  A61N5/062 ,  A61N7/02 ,  A61N2005/067 ,  A61N2007/0004

Abstract: Described are prodrug conjugates that release a chemotherapeutic agent upon activation by caspase, and methods using such prodrug conjugates to induce apoptosis, amplify apoptosis, and treat cancer.

公开(公告)号：US10357572B2

公开(公告)日：2019-07-23

申请号：US15690157

申请日：2017-08-29

Applicant: Pharosgen Co., Ltd.

Inventor： Sang-Yoon Kim ,  Youngro Byun ,  Seung Woo Chung

IPC: A61N1/40 ,  A61N5/06 ,  A61N7/00 ,  A61N7/02 ,  A61B18/02 ,  A61K31/65 ,  A61K38/14 ,  A61K45/06 ,  A61K47/54 ,  A61K47/55 ,  A61K47/60 ,  A61K47/61 ,  A61K47/64 ,  A61K47/65 ,  A61N5/067 ,  A61K31/337

Abstract: Described are prodrug conjugates that release a chemotherapeutic agent upon activation by caspase, and methods using such prodrug conjugates to induce apoptosis, amplify apoptosis, and treat cancer.