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    COMPOSITIONS AND METHODS FOR THE SUPPRESSION OF TARGET POLYNUCLEOTIDES FROM LEPIDOPTERA
    4.
    发明申请
    COMPOSITIONS AND METHODS FOR THE SUPPRESSION OF TARGET POLYNUCLEOTIDES FROM LEPIDOPTERA 审中-公开

    公开(公告)号：US20190271004A1

    公开(公告)日：2019-09-05

    申请号：US16411671

    申请日：2019-05-14

    申请人： PIONEER HI-BRED INTERNATIONAL, INC. ,  E. I. DU PONT DE NEMOURS AND COMPANY

    发明人： RAFAEL HERRMANN ,  MICHAEL LASSNER ,  ALBERT L. LU ,  MARK EDWARD NELSON ,  JAMES KEVIN PRESNAIL ,  JANET RICE

    IPC分类号： C12N15/82 ,  C12N15/113 ,  A01N65/44 ,  A01N65/20

    摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides set forth in SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Spodoptera frugiperda. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.

    SULFONYLUREA-RESPONSIVE REPRESSOR PROTEINS
    5.
    发明申请
    SULFONYLUREA-RESPONSIVE REPRESSOR PROTEINS 审中-公开
    SULFONYLUREA-RESPONSIVE REPRESSOR蛋白质

    公开(公告)号：US20150184169A1

    公开(公告)日：2015-07-02

    申请号：US14640163

    申请日：2015-03-06

    申请人： E I DU PONT DE NEMOURS AND COMPANY ,  PIONEER HI-BRED INTERNATIONAL INC

    发明人： MICHAEL LASSNER ,  Loren L Looger ,  Kevin E McBride ,  Brian McGonigle

    IPC分类号： C12N15/63 ,  C07K14/245

    CPC分类号： C07K14/245 ,  C07K14/195 ,  C12N15/635 ,  C12N15/8217 ,  C12N15/8238 ,  C12N15/8278

    摘要： Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.

    摘要翻译： 提供了与使用磺酰脲类阻遏物相关的组合物和方法。 组合物包括特异性结合操作者的多肽，其中特异性结合受磺酰脲化合物调节。 组合物还包括编码多肽的多核苷酸以及构建体，载体，原核和真核细胞，以及真核生物，包括包含多核苷酸的植物和种子，和/或由该方法产生的。 还提供了向细胞或生物体提供磺酰脲反应性阻遏物并调节目标多核苷酸在包括植物或植物细胞的细胞或生物体中的表达的方法。

    Compositions and Methods for the Suppression of Target Polynucleotides from Lepidoptera
    9.
    发明申请
    Compositions and Methods for the Suppression of Target Polynucleotides from Lepidoptera 审中-公开
    抑制鳞翅目标多核苷酸的组合物和方法

    公开(公告)号：US20150025124A1

    公开(公告)日：2015-01-22

    申请号：US14501240

    申请日：2014-09-30

    申请人： PIONEER HI BRED INTERNATIONAL INC ,  E I DU PONT DE NEMOURS AND COMPANY

    发明人： RAFAEL HERRMANN ,  MICHAEL LASSNER ,  ALBERT L. LU ,  MARK EDWARD NELSON ,  JAMES KEVIN PRESNAIL ,  JANET A. RICE

    IPC分类号： C12N15/82 ,  C12N15/113

    CPC分类号： C12N15/8286 ,  A01N65/20 ,  A01N65/44 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/32 ,  Y02A40/162

    摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides set forth in SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Spodoptera frugiperda. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.

    摘要翻译： 提供了使用沉积元件的方法和组合物，当沉积元件在被害虫如来自鳞翅目序列的害虫中摄取时，它们能够降低害虫中靶序列的表达。 在具体实施方案中，靶序列的表达降低控制有害生物，因此方法和组合物能够限制对植物的损害。 本发明提供编码来自特定蛋白质家族的多肽的多核苷酸和SEQ ID NO：1,2,3,4,5,6,7,8,9,10,11,12,13,14中所示的各种靶多核苷酸的靶多核苷酸 ，15，16，17，18，19，20，21，22，23，24，25，26，27，28，29，30，31，32，33，34，35，36，37，38，39 ，40,41,42,43,44,45,46,47,48,49或50个或其活性变体和片段，其中目标害虫中一个或多个序列的表达降低控制害虫（即 ，具有杀虫活性）。 进一步提供的是沉积元件，当受害虫摄入时，降低靶多肽的水平，从而控制害虫。 在具体实施方案中，害虫是草地夜蛾（Spodoptera frugiperda）。 还提供了包含本发明的沉默元件或其活性变体或片段的植物，植物部分，细菌和其它宿主细胞。