公开(公告)号：US09801972B2

公开(公告)日：2017-10-31

申请号：US14749844

申请日：2015-06-25

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon Cha ,  Yun Kee Jo ,  Hogyun Cheong ,  Changsup Kim ,  Bong-Hyuk Choi

IPC: A61L27/30 ,  A61L27/02 ,  C07K14/435 ,  A61L27/36 ,  A61K38/00

CPC classification number: A61L27/025 ,  A61K38/00 ,  A61L27/30 ,  A61L27/3604 ,  C07K14/43509 ,  C07K2319/00

Abstract: The present invention relates to a fusion protein comprising a mussel adhesive protein and a silica-binding peptide linked to the mussel adhesive protein, a silica nanoparticle a silica connected to the fusion protein, a fusion protein-silica nanoparticle complex comprising the silica nanoparticle having bioactivity and adhesiveness for cell proliferation and accelerating the differentiation, a surface coating composition including the complex, its use, and a method of coating a surface using the surface coating composition.

公开(公告)号：US20160096868A1

公开(公告)日：2016-04-07

申请号：US14749844

申请日：2015-06-25

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon CHA ,  Yun Kee Jo ,  Hogyun Cheong ,  Changsup Kim ,  Bong-Hyuk Choi

IPC: C07K14/435

CPC classification number: A61L27/025 ,  A61K38/00 ,  A61L27/30 ,  A61L27/3604 ,  C07K14/43509 ,  C07K2319/00

Abstract: The present invention relates to a fusion protein comprising a mussel adhesive protein and a silica-binding peptide linked to the mussel adhesive protein, a silica nanoparticle a silica connected to the fusion protein, a fusion protein-silica nanoparticle complex comprising the silica nanoparticle having bioactivity and adhesiveness for cell proliferation and accelerating the differentiation, a surface coating composition including the complex, its use, and a method of coating a surface using the surface coating composition.

Abstract translation: 本发明涉及包含贻贝粘合蛋白和与贻贝粘合蛋白连接的二氧化硅结合肽的融合蛋白，二氧化硅纳米颗粒与融合蛋白连接的二氧化硅，包含具有生物活性的二氧化硅纳米颗粒的融合蛋白 - 二氧化硅纳米颗粒复合物 以及细胞增殖的粘附性和促进分化，包括复合物的表面涂料组合物，其用途和使用表面涂料组合物涂布表面的方法。

公开(公告)号：US20160017279A1

公开(公告)日：2016-01-21

申请号：US14874508

申请日：2015-10-05

Applicant: Postech Academy-Industry Foundation

Inventor： Hyung Joon CHA ,  Bum Jin Kim ,  Yoo Seong Choi ,  Bong-Hyuk Choi

IPC: C12N5/00

CPC classification number: C12N5/0068 ,  B82Y5/00 ,  C07K14/43504 ,  C12N5/0654 ,  C12N2533/10 ,  C12N2533/40 ,  C12N2533/50 ,  C12N2533/70 ,  C12N2533/80 ,  C12N2537/00

Abstract: The present invention relates to technology of immobilizing or coating various functional bioactive substances on various surfaces without physical chemical treatment using mussel adhesive protein. More specifically, the present invention relates to a functional scaffold for tissue engineering comprising artificial extracellular matrix, manufactured by coating various functional bioactive substances on the surface of nanofiber and metal scaffold using mussel adhesive protein, and a method of manufacturing the same.

公开(公告)号：US11814556B2

公开(公告)日：2023-11-14

申请号：US16649224

申请日：2018-07-10

Applicant: POSCO ,  POSTECH ACADEMY-INDUSTRY FOUNDATION ,  NATURE GLUETECH CO., LTD.

Inventor： Hyung Joon Cha ,  Hyo Jeong Kim ,  Bong-Hyuk Choi

IPC: C09J189/00 ,  C07K14/435 ,  A61L24/10

CPC classification number: C09J189/00 ,  C07K14/43504

Abstract: A coacervate including a catechol-substituted anionic polymer; an adhesive including same; and a method for producing the coacervate are described. More specifically, a coacervate formed by mixing a catechol derivative of a mussel adhesive protein and a catechol-substituted anionic polymer; an adhesive including the coacervate; and a method for producing a coacervate are described. The method includes a step of obtaining a catechol-substituted anionic polymer through catechol substitution of an anionic polymer, and a step of mixing the catechol-substituted anionic polymer and a catechol derivative of a mussel adhesive protein.

公开(公告)号：US20200299556A1

公开(公告)日：2020-09-24

申请号：US16649224

申请日：2018-07-10

Applicant: POSCO ,  POSTECH ACADEMY-INDUSTRY FOUNDATION ,  NATURE GLUETECH CO., LTD.

Inventor： Hyung Joon Cha ,  Hyo Jeong Kim ,  Bong-Hyuk Choi

IPC: C09J189/00

Abstract: The present invention relates to: a coacervate formed from a catechol-substituted anionic polymer; an adhesive comprising same; and a method for producing same. More specifically, the present invention relates to: a coacervate formed by mixing a catechol derivative of a mussel adhesive protein and a catechol-substituted anionic polymer; an adhesive comprising the coacervate; and a method for producing a coacervate, wherein the method comprises a step of obtaining a catechol-substituted anionic polymer through catechol substitution of an anionic polymer, and a step of mixing the catechol-substituted anionic polymer and a catechol derivative of a mussel adhesive protein.