公开(公告)号：US12226535B2

公开(公告)日：2025-02-18

申请号：US17056340

申请日：2019-05-17

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon Cha ,  Eun Young Jeon ,  Jung Ho Lee ,  Geun Bae Lim

IPC: A61L15/32 ,  A61F13/00 ,  A61F13/02 ,  A61L15/28 ,  A61L15/58 ,  A61L15/60 ,  A61M37/00

Abstract: Disclosed are a microneedle patch including a first hydrogel layer containing a mussel adhesive protein and hyaluronic acid, and a second hydrogel layer containing silk fibroin, and a preparation method thereof. The microneedle patch according to the present disclosure has excellent tissue adhesion, biocompatibility, and biodegradability, and is used for transdermal drug delivery to promote wound regeneration.

公开(公告)号：US20160263136A1

公开(公告)日：2016-09-15

申请号：US15000551

申请日：2016-01-19

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon Cha ,  Bum Jin Kim ,  Ho gyun Cheong

IPC: A61K31/704 ,  A61K9/16

CPC classification number: A61K31/704 ,  A61K9/1617 ,  A61K9/1658 ,  A61K9/1682 ,  A61K9/5169 ,  A61K38/00 ,  A61K38/14

Abstract: The present invention relates to a pH-responsive metal-catechol derivative nanoparticle for drug delivery based on a mussel adhesive protein, particularly Fe(III)-DOPA nanoparticle, and a method for preparing the same. A nanoparticle for drug delivery according to the present invention is prepared using a pH responsive substance, catechol derivative-metal complex, particularly Fe(III)-DOPA complex, based on a mussel adhesive protein. Thereby, the present invention has excellent biocompatibility, is capable of easily and quickly penetrating into a target cell, and releases a loaded drug under acidic conditions, which enables to selectively deliver a drug to a specific disease having an acidic environment.

Abstract translation: 本发明涉及一种基于贻贝粘合蛋白，特别是Fe（III）-DOPA纳米颗粒的用于药物递送的pH响应性金属 - 儿茶酚衍生物纳米颗粒及其制备方法。 根据本发明的用于药物递送的纳米颗粒是使用基于贻贝粘合蛋白的pH响应物质，儿茶酚衍生物 - 金属络合物，特别是Fe（III）-DOPA复合物制备的。 因此，本发明具有优异的生物相容性，能够容易且快速地渗透到靶细胞中，并在酸性条件下释放负载药物，能够选择性地将药物递送至具有酸性环境的特定疾病。

公开(公告)号：US20210275359A1

公开(公告)日：2021-09-09

申请号：US17056340

申请日：2019-05-17

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon Cha ,  Eun Young Jeon ,  Jung Ho Lee ,  Geun Bae Lim

IPC: A61F13/02 ,  A61F13/00 ,  A61L15/58 ,  A61L15/60 ,  A61M37/00 ,  A61L15/28 ,  A61L15/32

Abstract: Disclosed are a microneedle patch including a first hydrogel layer containing a mussel adhesive protein and hyaluronic acid, and a second hydrogel layer containing silk fibroin, and a preparation method thereof. The microneedle patch according to the present disclosure has excellent tissue adhesion, biocompatibility, and biodegradability, and is used for transdermal drug delivery to promote wound regeneration.

公开(公告)号：US09801972B2

公开(公告)日：2017-10-31

申请号：US14749844

申请日：2015-06-25

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon Cha ,  Yun Kee Jo ,  Hogyun Cheong ,  Changsup Kim ,  Bong-Hyuk Choi

IPC: A61L27/30 ,  A61L27/02 ,  C07K14/435 ,  A61L27/36 ,  A61K38/00

CPC classification number: A61L27/025 ,  A61K38/00 ,  A61L27/30 ,  A61L27/3604 ,  C07K14/43509 ,  C07K2319/00

Abstract: The present invention relates to a fusion protein comprising a mussel adhesive protein and a silica-binding peptide linked to the mussel adhesive protein, a silica nanoparticle a silica connected to the fusion protein, a fusion protein-silica nanoparticle complex comprising the silica nanoparticle having bioactivity and adhesiveness for cell proliferation and accelerating the differentiation, a surface coating composition including the complex, its use, and a method of coating a surface using the surface coating composition.

公开(公告)号：US09675629B2

公开(公告)日：2017-06-13

申请号：US15000551

申请日：2016-01-19

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon Cha ,  Bum Jin Kim ,  Ho gyun Cheong

IPC: A61K9/51 ,  A61K31/704 ,  A61K9/16 ,  A61K38/00

CPC classification number: A61K31/704 ,  A61K9/1617 ,  A61K9/1658 ,  A61K9/1682 ,  A61K9/5169 ,  A61K38/00 ,  A61K38/14

Abstract: The present invention relates to a pH-responsive metal-catechol derivative nanoparticle for drug delivery based on a mussel adhesive protein, particularly Fe(III)-DOPA nanoparticle, and a method for preparing the same. A nanoparticle for drug delivery according to the present invention is prepared using a pH responsive substance, catechol derivative-metal complex, particularly Fe(III)-DOPA complex, based on a mussel adhesive protein. Thereby, the present invention has excellent biocompatibility, is capable of easily and quickly penetrating into a target cell, and releases a loaded drug under acidic conditions, which enables to selectively deliver a drug to a specific disease having an acidic environment.

公开(公告)号：US20140242870A1

公开(公告)日：2014-08-28

申请号：US14346993

申请日：2012-09-27

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Dong Soo Hwang ,  Dong Yeop Oh ,  Sang Sik Kim ,  Hyung Joon Cha

IPC: A61L27/20

CPC classification number: A61L27/20 ,  A61L27/50 ,  A61L2430/10 ,  A61L2430/12 ,  C08B37/003 ,  C08L5/08 ,  Y10T442/60

Abstract: The present invention relates to a composite including chitosan and/or chitin and a catechol-based compound, an organic reinforcing material composition including the composite, a product manufactured by using the organic reinforcing material composition, and a method for preparing a chitosan and/or chitin composite with improved strength, including the step of adding the catechol-based compound to chitosan and/or chitin. The chitosan and/or chitin composite including the catechol-based compound is advantageous in that it is able to maintain high strength in a wet-swollen state by improving the problem of strength reduction due to moisture, compared to the composites containing no catechol-based compound.

Abstract translation: 本发明涉及包含壳聚糖和/或壳多糖和儿茶酚类化合物的复合物，包含该复合物的有机增强材料组合物，使用有机增强材料组合物制造的产品，以及制备壳聚糖和/或 具有改善强度的几丁质复合物，包括将儿茶酚类化合物加入壳聚糖和/或壳多糖的步骤。 包含儿茶酚类化合物的壳聚糖和/或壳多糖复合物的优点在于，与不含儿茶酚类化合物的复合材料相比，通过改善由于水分引起的强度降低的问题，能够保持湿润膨胀状态下的高强度 复合。

公开(公告)号：US11814556B2

公开(公告)日：2023-11-14

申请号：US16649224

申请日：2018-07-10

Applicant: POSCO ,  POSTECH ACADEMY-INDUSTRY FOUNDATION ,  NATURE GLUETECH CO., LTD.

Inventor： Hyung Joon Cha ,  Hyo Jeong Kim ,  Bong-Hyuk Choi

IPC: C09J189/00 ,  C07K14/435 ,  A61L24/10

CPC classification number: C09J189/00 ,  C07K14/43504

Abstract: A coacervate including a catechol-substituted anionic polymer; an adhesive including same; and a method for producing the coacervate are described. More specifically, a coacervate formed by mixing a catechol derivative of a mussel adhesive protein and a catechol-substituted anionic polymer; an adhesive including the coacervate; and a method for producing a coacervate are described. The method includes a step of obtaining a catechol-substituted anionic polymer through catechol substitution of an anionic polymer, and a step of mixing the catechol-substituted anionic polymer and a catechol derivative of a mussel adhesive protein.

公开(公告)号：US20200291077A1

公开(公告)日：2020-09-17

申请号：US16497934

申请日：2018-03-27

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon Cha ,  Dong Pyo Kim ,  Yun Kee Jo ,  Kyoung Ik Min

IPC: C07K14/435 ,  C12M1/12 ,  A61K47/64 ,  A61K9/00

Abstract: The present invention relates to a porous microsphere comprising a mussel adhesive protein and a method of preparing the same. The porous microsphere comprising the mussel adhesive protein according to the present invention is capable of minimally invasive bio-injection through syringes to efficiently deliver therapeutic stem cells to the sites of tissue defects as cell carriers. Further, the present invention may be widely applied to scaffolds for tissue engineering, drug carriers, or the like, which may be suitably applied to the size of the defected site of tissue.

公开(公告)号：US12215172B2

公开(公告)日：2025-02-04

申请号：US17065368

申请日：2020-10-07

Applicant: Postech Academy-Industry Foundation

Inventor： Kye Il Joo ,  Hyung Joon Cha ,  Yeon Su Jeong

IPC: C07K16/44 ,  A61K45/00

Abstract: Disclosed are a bio-responsive adhesive antibody delivery platform for immunotherapy, use thereof, and a preparation method thereof. The bio-responsive adhesive antibody delivery platform for immunotherapy according to the present disclosure may enhance a retention time of the antibody at a target site via adhesiveness of the delivery platform and may selectively release the antibody in response to specific enzymes to efficiently deliver the antibody.

公开(公告)号：US11267851B2

公开(公告)日：2022-03-08

申请号：US16631133

申请日：2018-07-13

Applicant: POSCO ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon Cha ,  Yun Kee Jo ,  Yeonsu Jeong

IPC: A61K38/00 ,  A61K47/54 ,  A61K45/06 ,  A61K9/00 ,  A61K9/51 ,  A61K9/14 ,  A61P31/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435

Abstract: An antimicrobial adhesive protein, an antimicrobial nanoparticle, an antimicrobial composition comprising the same nanoparticle, and a preparation method for the same composition are described and, more particularly, an antimicrobial adhesive protein in which an antibiotic peptide is linked to a mussel adhesive protein, a mussel adhesive protein derivative of which a tyrosine residue within the antimicrobial adhesive protein is modified with a catechol derivative, an antimicrobial nanoparticle including a metal capable of forming a coordinate bond with a derivative of the mussel adhesive protein and having intrinsic antimicrobial activity, an antimicrobial composition comprising the same nanoparticle, and a preparation method for the same composition are described.