公开(公告)号：US09675629B2

公开(公告)日：2017-06-13

申请号：US15000551

申请日：2016-01-19

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon Cha ,  Bum Jin Kim ,  Ho gyun Cheong

IPC: A61K9/51 ,  A61K31/704 ,  A61K9/16 ,  A61K38/00

CPC classification number: A61K31/704 ,  A61K9/1617 ,  A61K9/1658 ,  A61K9/1682 ,  A61K9/5169 ,  A61K38/00 ,  A61K38/14

Abstract: The present invention relates to a pH-responsive metal-catechol derivative nanoparticle for drug delivery based on a mussel adhesive protein, particularly Fe(III)-DOPA nanoparticle, and a method for preparing the same. A nanoparticle for drug delivery according to the present invention is prepared using a pH responsive substance, catechol derivative-metal complex, particularly Fe(III)-DOPA complex, based on a mussel adhesive protein. Thereby, the present invention has excellent biocompatibility, is capable of easily and quickly penetrating into a target cell, and releases a loaded drug under acidic conditions, which enables to selectively deliver a drug to a specific disease having an acidic environment.

公开(公告)号：US20160263136A1

公开(公告)日：2016-09-15

申请号：US15000551

申请日：2016-01-19

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon Cha ,  Bum Jin Kim ,  Ho gyun Cheong

IPC: A61K31/704 ,  A61K9/16

CPC classification number: A61K31/704 ,  A61K9/1617 ,  A61K9/1658 ,  A61K9/1682 ,  A61K9/5169 ,  A61K38/00 ,  A61K38/14

Abstract: The present invention relates to a pH-responsive metal-catechol derivative nanoparticle for drug delivery based on a mussel adhesive protein, particularly Fe(III)-DOPA nanoparticle, and a method for preparing the same. A nanoparticle for drug delivery according to the present invention is prepared using a pH responsive substance, catechol derivative-metal complex, particularly Fe(III)-DOPA complex, based on a mussel adhesive protein. Thereby, the present invention has excellent biocompatibility, is capable of easily and quickly penetrating into a target cell, and releases a loaded drug under acidic conditions, which enables to selectively deliver a drug to a specific disease having an acidic environment.

Abstract translation: 本发明涉及一种基于贻贝粘合蛋白，特别是Fe（III）-DOPA纳米颗粒的用于药物递送的pH响应性金属 - 儿茶酚衍生物纳米颗粒及其制备方法。 根据本发明的用于药物递送的纳米颗粒是使用基于贻贝粘合蛋白的pH响应物质，儿茶酚衍生物 - 金属络合物，特别是Fe（III）-DOPA复合物制备的。 因此，本发明具有优异的生物相容性，能够容易且快速地渗透到靶细胞中，并在酸性条件下释放负载药物，能够选择性地将药物递送至具有酸性环境的特定疾病。

公开(公告)号：US20160017279A1

公开(公告)日：2016-01-21

申请号：US14874508

申请日：2015-10-05

Applicant: Postech Academy-Industry Foundation

Inventor： Hyung Joon CHA ,  Bum Jin Kim ,  Yoo Seong Choi ,  Bong-Hyuk Choi

IPC: C12N5/00

CPC classification number: C12N5/0068 ,  B82Y5/00 ,  C07K14/43504 ,  C12N5/0654 ,  C12N2533/10 ,  C12N2533/40 ,  C12N2533/50 ,  C12N2533/70 ,  C12N2533/80 ,  C12N2537/00

Abstract: The present invention relates to technology of immobilizing or coating various functional bioactive substances on various surfaces without physical chemical treatment using mussel adhesive protein. More specifically, the present invention relates to a functional scaffold for tissue engineering comprising artificial extracellular matrix, manufactured by coating various functional bioactive substances on the surface of nanofiber and metal scaffold using mussel adhesive protein, and a method of manufacturing the same.