公开(公告)号：US20170189476A1

公开(公告)日：2017-07-06

申请号：US15313220

申请日：2015-05-26

Applicant: GENEXINE, INC. ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Young Chul SUNG ,  Ji Yeung LEE ,  Mi-Young SONG ,  Hye Seong LIM ,  Byung Ha LEE

IPC: A61K38/17 ,  A61K39/00

CPC classification number: A61K38/17 ,  A61K38/00 ,  A61K39/0005 ,  C07K14/70596 ,  C07K2317/52 ,  C07K2319/30

Abstract: The present invention relates to a fusion protein composed of the extracellular domain of PD-L1 and a modified immunoglobulin Fc region. The extracellular domain of PD-L1 and a fragment thereof have excellent immunomodulatory activity, and can be used as an immunomodulatory agent if a modified immunoglobulin Fc region is coupled thereto. Accordingly, the PD-L1 fusion protein according to the present invention demonstrated its excellent effect in disease models of inflammatory bowel disease, colitis, psoriasis, asthma and arthritis, and thus can be very effectively used for the treatment of such diseases.

公开(公告)号：US20180036974A1

公开(公告)日：2018-02-08

申请号：US15522816

申请日：2016-04-25

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sei Kwang HAHN ,  Young Chul SUNG ,  Beom Ho MUN ,  Keon Jae LEE ,  Dohee KEUM ,  Su Jin KIM

IPC: B29D11/00 ,  G02C7/04 ,  A61F9/00

CPC classification number: B29D11/00096 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/6821 ,  A61F9/0017 ,  A61K9/0048 ,  A61K39/395 ,  A61M37/00 ,  G01N33/528 ,  G01N33/5438 ,  G01N33/66 ,  G01N2800/164 ,  G02B2027/0178 ,  G02C7/04 ,  G02C7/085 ,  G02C7/086

Abstract: The present invention provides a smart contact lens including a sensor capable of non-invasively sensing an eye disease in real time and a drug reservoir, and smart glasses for controlling the smart contact lens.

公开(公告)号：US20230398184A1

公开(公告)日：2023-12-14

申请号：US18250660

申请日：2021-10-25

Applicant: NeoImmuneTech, Inc. ,  GENEXINE, INC. ,  POSTECH Academy-Industry Foundation

Inventor： Donghoon CHOI ,  Young Chul SUNG ,  Seung-Woo LEE ,  Sora KIM ,  Young-Min KIM

IPC: A61K38/20 ,  A61K35/28 ,  A61K38/19 ,  A61K31/395

CPC classification number: A61K38/2046 ,  A61K35/28 ,  A61K38/193 ,  A61K31/395

Abstract: The present disclosure relates to methods of promoting the mobilization of HSCs to the peripheral blood with an IL-7 protein. In some aspects, the method further comprises administering an additional agent, such as G-CSF and/or AMD3100. In some aspects, the methods disclosed herein are useful in treating a disease or disorder associated with an abnormality of a hematopoietic process.