公开(公告)号：US20240287551A1

公开(公告)日：2024-08-29

申请号：US18572361

申请日：2022-02-28

申请人： POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION

发明人： Gyoo Yeol JUNG ,  Dae Yeol YE ,  Myung Hyun NOH ,  Myeong Won MIN

IPC分类号： C12P7/44 ,  C12N9/10 ,  C12N9/90 ,  C12N15/70

CPC分类号： C12P7/44 ,  C12N9/1029 ,  C12N9/90 ,  C12N15/70 ,  C12Y203/01182 ,  C12Y503/03006

摘要： The present invention relates to a novel metabolic pathway for producing itaconic acid and a recombinant microorganism, for producing itaconic acid, into which the metabolic pathway is introduced. It has been confirmed that the recombinant microorganism, for producing itaconic acid, into which the novel itaconic acid metabolic pathway is introduced, according to the present invention, significantly increases the production and yield of itaconic acid. In addition, as the recombinant microorganism for producing itaconic acid of the present invention uses an intermediate material of glycolysis rather than an intermediate material of the TCA cycle, the recombinant microorganism can further increase the production yield of itaconic acid through further improvement. Accordingly, the novel metabolic pathway for producing itaconic acid and the recombinant microorganism into which the metabolic pathway is introduced can increase the economic feasibility of itaconic acid, and thus can be variously used in industrial fields for synthetic resins, latexes, food additives, and the like in which itaconic acid is utilized.