公开(公告)号：US20220064677A1

公开(公告)日：2022-03-03

申请号：US17447568

申请日：2021-09-13

申请人： PRECIGEN, INC.

发明人： Xinhua ZHAO ,  Tina HUYNH ,  Jeffrey ORTH ,  Lily Yuin CHAO ,  James KEALEY

IPC分类号： C12P7/04 ,  C12N1/20 ,  C12N15/74

摘要： Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 1,4-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 1,4-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.

公开(公告)号：US20240263182A1

公开(公告)日：2024-08-08

申请号：US18582362

申请日：2024-02-20

申请人： PRECIGEN, INC.

发明人： Xinhua ZHAO ,  Mark Anton HELD ,  Tina HUYNH ,  Lily Yuin CHAO ,  Na TRINH ,  Matthias Helmut SCHMALISCH ,  Bryan YEH ,  James KEALEY ,  Kevin Lee DIETZEL

IPC分类号： C12N15/52 ,  C12N1/20 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88 ,  C12N15/74 ,  C12P5/02 ,  C12P7/16 ,  C12P7/18

CPC分类号： C12N15/52 ,  C12N1/20 ,  C12N9/0006 ,  C12N9/1022 ,  C12N9/88 ,  C12N15/74 ,  C12P5/023 ,  C12P7/16 ,  C12P7/18 ,  C12Y101/01304 ,  C12Y202/01006 ,  C12Y401/01004 ,  C12Y401/01005

摘要： Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.

公开(公告)号：US20230051667A1

公开(公告)日：2023-02-16

申请号：US17811776

申请日：2022-07-11

申请人： PRECIGEN, INC.

发明人： Jeffrey David ORTH ,  Louis A. CLARK ,  Lily Yuin CHAO ,  Na My TRINH ,  Christopher Cheyney FARWELL ,  Xinhua ZHAO ,  Matthias Helmut SCHMALISCH ,  Grayson Thomas WAWRZYN ,  Xuezhi LI ,  Mark Anton HELD ,  Kevin Lee DIETZEL ,  James KEALEY

IPC分类号： C12N15/52 ,  C12N9/04 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12N15/70 ,  C12P7/16 ,  C12P7/24

摘要： Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as isobutanol are disclosed. For example, genetically modified methanotrophs that are capable of generating isobutanol at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.

公开(公告)号：US20220112506A1

公开(公告)日：2022-04-14

申请号：US17454060

申请日：2021-11-08

申请人： PRECIGEN, INC.

发明人： Mark Anton HELD ,  Xinhua ZHAO ,  Lily Yuin CHAO ,  Na TRINH ,  James KEALEY ,  Kevin Lee DIETZEL

IPC分类号： C12N15/52 ,  C12N1/20 ,  C12N9/88 ,  C12N15/74 ,  C12P7/16 ,  C12P7/18 ,  C12N9/10 ,  C12N9/04 ,  C12P5/02

摘要： Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO; 1,4-BDO; isobutyraldehyde; isobutanol; 1-butanol; n-butanol; ethanol; fatty alcohols; and fatty acid methyl ester are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO; 1,4-BDO; isobutyraldehyde; isobutanol; 1-butanol; n-butanol; ethanol; fatty alcohols; and fatty acid methyl ester at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed. These microorganisms and methods make use of molecular switches to regulate gene expression.