公开(公告)号：US20190144567A1

公开(公告)日：2019-05-16

申请号：US16302023

申请日：2017-05-16

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Daniel Christopher LESLIE ,  Thomas DOYLE ,  Anna WATERHOUSE ,  Melissa RODAS ,  Alexander L. WATTERS ,  Michael SUPER ,  Donald E. INGBER

IPC: C07K17/08 ,  C08L25/06 ,  C08L83/04 ,  G01N33/545 ,  G01N33/543

Abstract: This disclosure provides, e.g., methods for coupling an entity to a solid substrate. The method can comprise treating the substrate with a plasma, e.g., a CO2 plasma, to increase its reactivity. The entity can be, e.g., a biological polymer that binds a microbe. Substrates produced by these methods can be used in a variety of applications, including hemodialysis and diagnostic assays.