公开(公告)号：US20160144079A1

公开(公告)日：2016-05-26

申请号：US14904399

申请日：2014-07-10

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Donald INGBER ,  Daniel C. LESLIE ,  Michael SUPER ,  Alexander L. WATTERS ,  Anna WATERHOUSE

IPC: A61L31/08

CPC classification number: A61L31/08 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/14 ,  A61L2400/10 ,  A61L2420/02 ,  B05D5/08 ,  B05D5/086 ,  C09D5/16

Abstract: Articles, methods of making, and uses for modifying surfaces for liquid repellency are disclosed. The liquid repellant surfaces comprise a surface comprising an anchoring layer. The anchoring layer, which forms an immobilized molecular anchoring layer on the surface, has anchoring molecules, where each anchoring molecule has a head group that is covalently linked to the surface and a functional tail group. The anchoring molecules are crosslinked to each other to form a crosslinked network. The functional tail group has an affinity for a lubricating liquid, which is applied to the treated surface to form a lubricating layer. The anchoring layer and replenishable lubricating liquid are held together by non-covalent attractive forces. Together, these layers form an ultra-repellant slippery surface that repels certain immiscible liquids and prevents adsorption, coagulation, and surface fouling by components contained within.

Abstract translation: 公开了制品的制造方法和用于改性表面的疏液性的用途。 排液表面包括包含锚定层的表面。 在表面上形成固定化分子锚定层的锚定层具有锚定分子，其中每个锚定分子具有与表面共价连接的头基和功能尾组。 锚定分子彼此交联以形成交联网络。 功能尾组对润滑液具有亲和性，润滑液被施加到被处理表面以形成润滑层。 锚定层和补充润滑液通过非共价吸引力保持在一起。 一起，这些层形成一个超疏水滑表面，排斥某些不混溶的液体，并防止其中所含组分的吸附，凝结和表面结垢。

公开(公告)号：US20190144567A1

公开(公告)日：2019-05-16

申请号：US16302023

申请日：2017-05-16

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Daniel Christopher LESLIE ,  Thomas DOYLE ,  Anna WATERHOUSE ,  Melissa RODAS ,  Alexander L. WATTERS ,  Michael SUPER ,  Donald E. INGBER

IPC: C07K17/08 ,  C08L25/06 ,  C08L83/04 ,  G01N33/545 ,  G01N33/543

Abstract: This disclosure provides, e.g., methods for coupling an entity to a solid substrate. The method can comprise treating the substrate with a plasma, e.g., a CO2 plasma, to increase its reactivity. The entity can be, e.g., a biological polymer that binds a microbe. Substrates produced by these methods can be used in a variety of applications, including hemodialysis and diagnostic assays.