公开(公告)号：US20220259320A1

公开(公告)日：2022-08-18

申请号：US17682922

申请日：2022-02-28

申请人： PROMETHEUS BIOSCIENCES, INC. ,  CEDARS-SINAI MEDICAL CENTER

发明人： Jeffry D. Watkins ,  Cindy T. Dickerson ,  Rafael Rojas ,  Matthew Reissman ,  Patricia McNeeley ,  Janine Bilsborough ,  Bradley Henkle ,  Stephan R. Targan

IPC分类号： C07K16/28 ,  A61P1/04 ,  C07K16/24

摘要： Described herein are humanized anti-TL1A antibodies and pharmaceutical compositions for the treatment of inflammatory bowel disease (IBD), such as Crohn's Disease (CD) and ulcerative colitis (UC).

公开(公告)号：US11999789B2

公开(公告)日：2024-06-04

申请号：US17682922

申请日：2022-02-28

申请人： PROMETHEUS BIOSCIENCES, INC. ,  CEDARS-SINAI MEDICAL CENTER

发明人： Jeffry D. Watkins ,  Cindy T. Dickerson ,  Rafael Rojas ,  Matthew Reissman ,  Patricia McNeeley ,  Janine Bilsborough ,  Bradley Henkle ,  Stephan R. Targan

IPC分类号： C07K16/24 ,  A61P1/04 ,  C07K16/28 ,  A61K39/395 ,  C07K14/52 ,  C07K14/525

CPC分类号： C07K16/2875 ,  A61P1/04 ,  C07K16/241 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/40 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/76

摘要： Described herein are humanized anti-TL1A antibodies and pharmaceutical compositions for the treatment of inflammatory bowel disease (IBD), such as Crohn's Disease (CD) and ulcerative colitis (UC).

公开(公告)号：US20230192835A1

公开(公告)日：2023-06-22

申请号：US17931049

申请日：2022-09-09

申请人： Prometheus Biosciences, Inc. ,  CEDARS-SINAI MEDICAL CENTER

发明人： Jeffry D. Watkins ,  Cindy T. Dickerson ,  J. Monty Watkins ,  Patricia McNeeley ,  Janine Bilsborough ,  Bradley Henkle ,  Stephan R. Targan

IPC分类号： C07K16/24 ,  A61P1/04 ,  C07K16/28 ,  A61P1/00 ,  A61K9/00 ,  C12N15/09 ,  C12N15/63 ,  C12N5/10

CPC分类号： C07K16/24 ,  A61P1/04 ,  C07K16/241 ,  C07K16/28 ,  A61P1/00 ,  A61K9/0019 ,  C07K16/2875 ,  C12N15/09 ,  C12N15/63 ,  C12N5/10 ,  A61K39/3955

摘要： Described herein are humanized anti-TL1A antibodies and pharmaceutical compositions for the treatment of inflammatory bowel disease (IBD), such as Crohn's Disease (CD) and ulcerative colitis (UC).

公开(公告)号：US20240327532A1

公开(公告)日：2024-10-03

申请号：US18645261

申请日：2024-04-24

申请人： PROMETHEUS BIOSCIENCES, INC. ,  CEDARS-SINAI MEDICAL CENTER

发明人： Jeffry D. Watkins ,  Cindy T. Dickerson ,  Rafael Rojas ,  Matthew Reissman ,  Patricia McNeeley ,  Janine Bilsborough ,  Bradley Henkle ,  Stephan R. Targan

IPC分类号： C07K16/28 ,  A61P1/04 ,  C07K16/24

CPC分类号： C07K16/2875 ,  A61P1/04 ,  C07K16/241 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/40 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/76

摘要： Described herein are humanized anti-TL1A antibodies and pharmaceutical compositions for the treatment of inflammatory bowel disease (IBD), such as Crohn's Disease (CD) and ulcerative colitis (UC).

公开(公告)号：US11440954B2

公开(公告)日：2022-09-13

申请号：US16863971

申请日：2020-04-30

申请人： Prometheus Biosciences, Inc. ,  Cedars-Sinai Medical Center

发明人： Jeffry D. Watkins ,  Cindy T. Dickerson ,  J. Monty Watkins ,  Patricia McNeeley ,  Janine Bilsborough ,  Bradley Henkle ,  Stephan R. Targan

IPC分类号： C07K16/24 ,  C07K16/28 ,  C12N5/10 ,  C12N15/09 ,  C12N15/63 ,  A61P1/04 ,  A61P1/00 ,  A61K9/00 ,  C07K14/525 ,  C07K14/715 ,  A61K39/395 ,  A61K39/00

摘要： Described herein are humanized anti-TL1A antibodies and pharmaceutical compositions for the treatment of inflammatory bowel disease (IBD), such as Crohn's Disease (CD) and ulcerative colitis (UC).

公开(公告)号：US11292848B2

公开(公告)日：2022-04-05

申请号：US17110004

申请日：2020-12-02

申请人： PROMETHEUS BIOSCIENCES, INC. ,  CEDARS-SINAI MEDICAL CENTER

发明人： Jeffry D. Watkins ,  Cindy T. Dickerson ,  Rafael Rojas ,  Matthew Reissman ,  Patricia McNeeley ,  Janine Bilsborough ,  Bradley Henkle ,  Stephan R. Targan

IPC分类号： C07K16/24 ,  C07K16/28 ,  A61P1/04 ,  C07K14/52 ,  C07K14/525 ,  A61K39/395

摘要： Described herein are humanized anti-TL1A antibodies and pharmaceutical compositions for the treatment of inflammatory bowel disease (IBD), such as Crohn's Disease (CD) and ulcerative colitis (UC).

公开(公告)号：US20230381308A1

公开(公告)日：2023-11-30

申请号：US18191712

申请日：2023-03-28

申请人： CEDARS-SINAI MEDICAL CENTER

发明人： Janine Bilsborough ,  Stephan R. Targan ,  Bradley Henkle

IPC分类号： A61K39/395 ,  C07K16/24 ,  C07K16/28 ,  A61P37/00 ,  A61P1/02 ,  A61P29/00 ,  A61K48/00

CPC分类号： A61K39/39533 ,  C07K16/241 ,  C07K16/2875 ,  A61P37/00 ,  A61P1/02 ,  A61P29/00 ,  A61K48/005 ,  C07K16/2809 ,  C07K2317/56 ,  A61K2039/505

摘要： Described herein are methods and pharmaceutical compositions for the treatment of inflammatory bowel disease (IBD), Crohn's Disease (CD), ulcerative colitis (UC) and medically refractive-ulcerative colitis (MR-UC). In particular, disclosed are anti-TL1A antibodies useful for the treatment of IBD.

公开(公告)号：US20230091596A1

公开(公告)日：2023-03-23

申请号：US17814704

申请日：2022-07-25

申请人： CEDARS-SINAI MEDICAL CENTER

发明人： David Q. Shih ,  Stephan R. Targan ,  Dalin Li ,  Janine Bilsborough

IPC分类号： C07K16/28 ,  C07K16/24 ,  A61K39/395 ,  C12N15/113 ,  G01N33/68

摘要： The invention relates to methods of treating fibrosis and inflammatory bowel disease. In one embodiment, the present invention treats gut inflammation by administering a therapeutically effective dosage of TL1A inhibitors and/or DR3 inhibitors to an individual. In another embodiment, the present invention provides a method of reversing tissue fibrosis in an individual by inhibiting TL1A-DR3 signaling function.

公开(公告)号：US20230020356A1

公开(公告)日：2023-01-19

申请号：US17334109

申请日：2021-05-28

申请人： Cedars-Sinai Medical Center

发明人： Rebecca Gonsky ,  Stephan R. Targan

IPC分类号： C12Q1/6883

摘要： Described herein are methods and systems for identifying subpopulations of patients having Crohn's disease, including populations at risk of developing structuring or other severe disease, and populations susceptible to success or failure with surgical intervention. Further provided are therapies useful for treating subpopulations of patients having Crohn's disease.

公开(公告)号：US20200149110A1

公开(公告)日：2020-05-14

申请号：US16683141

申请日：2019-11-13

申请人： Cedars-Sinai Medical Center

发明人： Stephan R. Targan ,  Marla C. Dubinsky ,  Carol J. Landers ,  Ling Mei ,  Jerome I. Rotter ,  Kent D. Taylor

IPC分类号： C12Q1/6883 ,  G01N33/68

摘要： This invention provides methods of diagnosis, predicting and diagnosing susceptibility to, predicting disease progression and treatment of inflammatory bowel disease (IBD), including Crohn's disease and/or subtypes of Crohn's disease (CD) and/or Ulcerative Colitis (UC). In one embodiment, a method of the invention is practiced by determining the presence or absence of the genetic variants NOD2, TLR8, TLR2, CARD8, CARD15 and/or JAK3 to diagnose, predict and diagnose susceptibility and predict disease progression in an individual. In another embodiment, a method of the invention is practiced by determining the presence or absence of anti-Cbir1, anti-OmpC, ASCA, anti-I2 and/or pANCA in an individual. In another embodiment, the invention further associates the presence or absence of the risk variants with the expression of anti-Cbir1, anti-OmpC, ASCA, anti-I2 and/or pANCA for the diagnosis, prediction of susceptibility, prediction of disease progression and/or treatment of IBD, including CD and/or UC.