公开(公告)号：US11931400B2

公开(公告)日：2024-03-19

申请号：US15914925

申请日：2018-03-07

申请人： PSOMAGEN, INC.

发明人： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Melissa Alegria ,  Valeria Marquez ,  Eduardo Morales ,  Rodrigo Ortiz ,  Janet Torres ,  Paulo Covarrubias ,  Javier Gimpel ,  Ingrid Araya

IPC分类号： C07K14/00 ,  A61K38/08 ,  A61K38/16 ,  G01N33/68

CPC分类号： A61K38/164 ,  A61K38/08 ,  C07K14/001 ,  G01N33/68 ,  Y02A50/30

摘要： Therapeutic compositions and an associated method for improving a Toll-like receptor (TLR)-related condition, including determining a set of peptide sequences associated with a microorganism-related modulator of a TLR, determining a first set of binding parameters for the set of peptide sequences in relation to the TLR, selecting a target subset of peptide sequences from the set of peptide sequences based on the first set of binding parameters, reengineering the target subset of peptide sequences based on mutating amino acid residues of the target subset of peptide sequences, determining a second set of binding parameters for the reengineered target subset of peptide sequences in relation to the TLR, and identifying a first peptide for use in a therapeutic composition for improving the TLR-related condition, based on the second set of binding parameters for the reengineered target subset of peptide sequences.

公开(公告)号：US20220189584A1

公开(公告)日：2022-06-16

申请号：US17598954

申请日：2020-03-27

申请人： PSOMAGEN INC.

发明人： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Valeria Marquez

IPC分类号： G16B40/20 ,  G16B15/20 ,  A61K35/741 ,  G16B20/00

摘要： A method for treating a microorganism-related condition in a patient may include detecting microorganisms in a set of samples collected from a population and comparing a relative abundance of and co-occurrence between different microbial taxa in the set of samples. The method further includes associating a change in the relative abundance of or the co-occurrence between the microbial taxa with samples from people, among the population, with the microorganism-related condition and samples from people, among the population, without the microorganism-related condition to determine a target taxa. A blend of bacteriophages is then identified, the blend being configured to remove the target taxa from a community of microorganisms A therapeutic composition comprising the blend is then administered to the patient with the microorganism-related condition.

公开(公告)号：US20210074384A1

公开(公告)日：2021-03-11

申请号：US16755233

申请日：2019-03-18

申请人： PSOMAGEN, INC.

发明人： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Inti Pedroso ,  Victoria Dumas ,  Valeria Marquez ,  Ingrid Araya ,  Ricardo Castro ,  Mario Saavedra ,  Melissa Alegria

IPC分类号： G16B40/20 ,  A61B5/00 ,  G16B40/30 ,  G16B20/00 ,  G16B15/00 ,  G16H50/20 ,  G16H50/30 ,  G16H70/40 ,  G16H20/10 ,  G16H50/50 ,  G16H20/60

摘要： Embodiments of a method and/or system (e.g, for metabolism-related prediction) can include: generating an enzyme dataset; generating a substrate dataset; generating a metabolism model such as for predicting an enzyme feature associated with metabolism of a query molecule, based on the enzyme dataset and/or the substrate dataset; determining a microorganism taxon (and/or microorganism taxa) S140 associated with the metabolism of the query molecule based on one or more predicted enzyme features of the metabolism model (e.g., machine learning model; etc.) and/or determining a query molecule score (e.g., drug score) for one or more users based on the microorganism taxon.

公开(公告)号：US11424006B2

公开(公告)日：2022-08-23

申请号：US16638779

申请日：2018-08-14

申请人： Psomagen, Inc.

发明人： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Valeria Marquez ,  Ingrid Araya ,  Melissa Alegria ,  Mario Saavedra ,  Luis Gomez ,  Janyra Espinoza ,  Javier Gimpel ,  Eduardo Morales ,  Rodrigo Ortiz

IPC分类号： G16B15/00 ,  G16B5/00 ,  A61K31/047 ,  A61P9/10 ,  A61K31/40 ,  A61K31/045 ,  A61K31/4409 ,  A61K31/166 ,  A61K31/05 ,  A61K31/4196 ,  A61K31/12 ,  A61K31/14 ,  A61K31/415 ,  A61K31/192 ,  A61K31/4406 ,  A61K31/216 ,  G16B15/30 ,  A61K31/015 ,  A61P31/04 ,  A61P13/12 ,  A61K31/075 ,  A61K31/085 ,  A61K31/11 ,  A61K31/121 ,  A61K31/122 ,  A61K31/133 ,  A61K31/136 ,  A61K31/15 ,  A61K31/16 ,  A61K31/164 ,  A61K31/165 ,  A61K31/167 ,  A61K31/185 ,  A61K31/198 ,  A61K31/22 ,  A61K31/222 ,  A61K31/235 ,  A61K31/26 ,  A61K31/277 ,  A61K31/336 ,  A61K31/341 ,  A61K31/343 ,  A61K31/357 ,  A61K31/36 ,  A61K31/365 ,  A61K31/37 ,  A61K31/381 ,  A61K31/4015 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/41 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/4465 ,  A61K31/50 ,  A61K31/502 ,  A61K31/517 ,  A61P1/12

摘要： Embodiments of a method and/or system can include administering, to a patient with one or more conditions associated with at least one of TMA, TMAO, and/or derivatives thereof, a therapeutically effective amount of a compound for affecting inhibiting one or more CutC enzymes and/or CntA enzymes associated with microorganisms from at least one taxon from a set of microorganism taxa.

公开(公告)号：US20220122691A1

公开(公告)日：2022-04-21

申请号：US17420756

申请日：2020-01-06

申请人： PSOMAGEN INC.

发明人： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Valeria Marquez

IPC分类号： G16B15/30 ,  C07C317/14

摘要： The present application relates to new HtrA inhibitors and use thereof. Additionally, the present application also relates to new peptides for inhibiting CagA and use thereof.