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    Conditioned medium and proliferated cell lines produced therefrom
    3.
    发明授权
    Conditioned medium and proliferated cell lines produced therefrom 有权
    条件培养基和由其生产的增殖细胞系

    公开(公告)号：US08337829B2

    公开(公告)日：2012-12-25

    申请号：US13267346

    申请日：2011-10-06

    申请人： Thomas B. Freeman ,  Pablo Caviedes ,  Raul Caviedes

    发明人： Thomas B. Freeman ,  Pablo Caviedes ,  Raul Caviedes

    IPC分类号： C12N5/02 ,  C12N5/07 ,  C12N5/0735 ,  C12N5/074 ,  C12N5/0789 ,  C12N5/0797 ,  C12N5/10

    CPC分类号： A61K35/26 ,  C12N5/0018 ,  C12N2500/84 ,  C12N2502/078 ,  C12N2502/30 ,  C12N2503/02

    摘要： The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferating cells in culture by contacting cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, non-fertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferated cells of the subject invention are useful for cell therapy, cell/gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.

    摘要翻译： 本发明涉及可用于增加培养物中任何人或动物细胞的增殖潜力的肿瘤细胞系，从而提供永生化或连续的细胞系和培养物。 本发明还涉及增殖因子和含有因子的组合物，其能够增加培养物中任何人或其他动物细胞的增殖潜力。 本发明还涉及通过使细胞与增殖因子接触来增殖培养细胞的方法。 增殖的细胞可以在可塑性范围内，并且可以包括例如胚细胞，受精卵，非受精配子，胚胎干细胞，成体干细胞，前体或祖细胞和高度专门的细胞。 任选地，可诱导细胞停止增殖。 本发明的增殖细胞可用于细胞治疗，细胞/基因治疗，分子的生物制备，以及用于研究，毒性测试和药物开发的体外模型。

    Proliferated cell lines and uses thereof
    4.
    发明申请
    Proliferated cell lines and uses thereof 有权
    增殖细胞系及其用途

    公开(公告)号：US20080175828A1

    公开(公告)日：2008-07-24

    申请号：US11981945

    申请日：2007-10-31

    申请人： Thomas B. Freeman ,  Pablo Caviedes ,  Raul Caviedes

    发明人： Thomas B. Freeman ,  Pablo Caviedes ,  Raul Caviedes

    IPC分类号： A61K35/12 ,  C07K14/00 ,  C12Q1/02 ,  A61P25/00 ,  A61P1/00 ,  C12N5/06

    CPC分类号： A61K35/26 ,  C12N5/0018 ,  C12N2500/84 ,  C12N2502/078 ,  C12N2502/30 ,  C12N2503/02

    摘要： The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferating cells in culture by containing cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, non-fertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferated cells of the subject invention are useful for cell therapy, cell/gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.

    摘要翻译： 本发明涉及可用于增加培养物中任何人或动物细胞的增殖潜力的肿瘤细胞系，从而提供永生化或连续的细胞系和培养物。 本发明还涉及增殖因子和含有因子的组合物，其能够增加培养物中任何人或其他动物细胞的增殖潜力。 本发明还涉及通过含有增殖因子的细胞来增殖培养细胞的方法。 增殖的细胞可以在可塑性范围内，并且可以包括例如胚细胞，受精卵，非受精配子，胚胎干细胞，成体干细胞，前体或祖细胞和高度专门的细胞。 任选地，可诱导细胞停止增殖。 本发明的增殖细胞可用于细胞治疗，细胞/基因治疗，分子的生物制备，以及用于研究，毒性测试和药物开发的体外模型。

    Proliferated cell lines and uses thereof
    5.
    发明授权
    Proliferated cell lines and uses thereof 有权
    增殖细胞系及其用途

    公开(公告)号：US08137662B2

    公开(公告)日：2012-03-20

    申请号：US11981945

    申请日：2007-10-31

    申请人： Thomas B. Freeman ,  Pablo Caviedes ,  Raul Caviedes

    发明人： Thomas B. Freeman ,  Pablo Caviedes ,  Raul Caviedes

    IPC分类号： A61K35/12

    CPC分类号： A61K35/26 ,  C12N5/0018 ,  C12N2500/84 ,  C12N2502/078 ,  C12N2502/30 ,  C12N2503/02

    摘要： The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferating cells in culture by containing cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, non-fertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferated cells of the subject invention are useful for cell therapy, cell/gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.

    摘要翻译： 本发明涉及可用于增加培养物中任何人或动物细胞的增殖潜力的肿瘤细胞系，从而提供永生化或连续的细胞系和培养物。 本发明还涉及增殖因子和含有因子的组合物，其能够增加培养物中任何人或其他动物细胞的增殖潜力。 本发明还涉及通过含有增殖因子的细胞来增殖培养细胞的方法。 增殖的细胞可以在可塑性范围内，并且可以包括例如胚细胞，受精卵，非受精配子，胚胎干细胞，成体干细胞，前体或祖细胞和高度专门的细胞。 任选地，可诱导细胞停止增殖。 本发明的增殖细胞可用于细胞治疗，细胞/基因治疗，分子的生物制备，以及用于研究，毒性测试和药物开发的体外模型。

    Proliferated cell lines and uses thereof
    6.
    发明授权
    Proliferated cell lines and uses thereof 有权
    增殖细胞系及其用途

    公开(公告)号：US07416885B2

    公开(公告)日：2008-08-26

    申请号：US10359854

    申请日：2003-02-07

    申请人： Thomas B. Freeman ,  Pablo Caviedes ,  Raul Caviedes

    发明人： Thomas B. Freeman ,  Pablo Caviedes ,  Raul Caviedes

    IPC分类号： C12N5/00

    CPC分类号： A61K35/26 ,  C12N5/0018 ,  C12N2500/84 ,  C12N2502/078 ,  C12N2502/30 ,  C12N2503/02

    摘要： The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferation cells in culture by contacting cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, non-fertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferation cells of the subject invention are useful for cell therapy, cell/gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.

    摘要翻译： 本发明涉及可用于增加培养物中任何人或动物细胞的增殖潜力的肿瘤细胞系，从而提供永生化或连续的细胞系和培养物。 本发明还涉及增殖因子和含有因子的组合物，其能够增加培养物中任何人或其他动物细胞的增殖潜力。 本发明进一步涉及通过使细胞与增殖因子接触而在培养物中增殖细胞的方法。 增殖的细胞可以在可塑性范围内，并且可以包括例如胚细胞，受精卵，非受精配子，胚胎干细胞，成体干细胞，前体或祖细胞和高度专门的细胞。 任选地，可诱导细胞停止增殖。 本发明的增殖细胞可用于细胞治疗，细胞/基因治疗，分子的生物制备，以及用于研究，毒性测试和药物开发的体外模型。

    Adaptation sphere saddle
    7.
    发明授权
    Adaptation sphere saddle 有权

    公开(公告)号：US09968378B1

    公开(公告)日：2018-05-15

    申请号：US15199053

    申请日：2016-06-30

    申请人： Wesley M. Johnson ,  Thomas B. Freeman

    发明人： Wesley M. Johnson ,  Thomas B. Freeman

    IPC分类号： A61B17/70

    CPC分类号： A61B17/7037 ,  A61B17/7002 ,  A61B17/7032

    摘要： An improvement of a polyaxial screw head disclosed in the U.S. Pat. No. 8,277,490. A saddle resides within a tulip. The saddle is configured to mate with a rod. An outer set screw engages an inner surface of the tulip. An inner set screw is disposed within a lumen of an outer set screw. A force distributor has a concave surface configured to mate with the rod. The force distributor has a bore configured to accept a conical end of the inner set screw. The force distributor is configured to distribute the force applied onto the bore by the inner set screw along the contact area with rod. The force distributor allows the rod to pivot and have sagittal motion when the inner set screw is untightened. The force distributor immobilizes the rod within the saddle when the inner set screw is tightened.

    Cervical plate system
    8.
    发明授权
    Cervical plate system 有权
    宫颈板系统

    公开(公告)号：US07963980B1

    公开(公告)日：2011-06-21

    申请号：US11736627

    申请日：2007-04-18

    申请人： Thomas B. Freeman ,  Wesley Johnson

    发明人： Thomas B. Freeman ,  Wesley Johnson

    IPC分类号： A61B17/80

    CPC分类号： A61B17/7059 ,  A61B17/1728 ,  A61B17/1757 ,  A61B17/8014 ,  A61B17/808

    摘要： An anti-subsidence, anti-translocation, fusion compression cervical plate system with interface visualization, drill guide and temporary pin is provided. In one embodiment the invention provides a vertebral plate for minimizing the ability of an inter-body cage, filled with bone (or BMP-soaked sponges, etc.), to telescope into the vertebral body and to minimize failure due to cages that telescope into adjacent vertebral bodies on a delayed basis after surgery, as well as creation of reverse lordosis due to such telescoping. Another embodiment provides method to reduce the gap between the inter-body cage and the vertebral body end plate intra-operatively using compression from the plate caused by an offset between the screw bores on the plate and the drill holes, as established with an asymmetric drill guide.

    摘要翻译： 提供了具有界面可视化的抗沉降，抗移位，融合压缩宫颈板系统，钻引导和临时引脚。 在一个实施例中，本发明提供了一种脊椎板，用于使填充有骨（或BMP-浸泡的海绵等）的体间笼子的能力最小化，以望远镜到椎体中并且将由于笼罩的望远镜 手术后延迟的相邻椎体，以及由于这种伸缩引起的反向脊柱前凸的产生。 另一个实施例提供了如下方法：使用由不对称钻头建立的板上螺钉孔与钻孔之间的偏移引起的板内压缩从而减小了体内笼与椎体内端板之间的间隙 指南。