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1.发明申请公开(公告)号：US20070066573A1
公开(公告)日：2007-03-22
申请号：US10570985
申请日：2004-09-27
申请人： Pamela Albaugh , Esteban Dominguez-Manzanares , Jian Hong , William Hornback , Delu Jiang , Paul Ornstein , Michelle Thompson , Eric Tromiczak , Zhipei Wu , Hamideh Zarrinmayeh , Dennis Zimmerman , Ana Castano Mansanet , Larry Huffman , William Miller
发明人： Pamela Albaugh , Esteban Dominguez-Manzanares , Jian Hong , William Hornback , Delu Jiang , Paul Ornstein , Michelle Thompson , Eric Tromiczak , Zhipei Wu , Hamideh Zarrinmayeh , Dennis Zimmerman , Ana Castano Mansanet , Larry Huffman , William Miller
IPC分类号： A61K31/675 , A61K31/433 , A61K31/4196 , A61K31/42 , A61K31/425 , A61K31/415 , A61K31/416 , A61K31/4025 , A61K31/401 , C07D417/02 , C07D413/02 , C07D405/02 , C07D403/02
CPC分类号： C07D207/34 , C07D207/36 , C07D231/14 , C07D401/10 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/10 , C07D409/10 , C07D409/12 , C07D413/10 , C07D417/10
摘要： The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.
摘要翻译： 本发明涉及式（I）的吡咯和吡唑化合物及其药学上可接受的盐，并且还涉及它们在治疗精神分裂症，与精神分裂症相关的认知缺陷，阿尔茨海默病，阿尔茨海默氏型痴呆，轻度认知障碍或 萧条。 这些化合物作为谷氨酸受体，特别是AMPA和GluR家族的增效剂。
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公开(公告)号：US20070105852A1
公开(公告)日：2007-05-10
申请号：US10596419
申请日：2005-01-05
申请人： Ana Castano Mansanet , Esteban Dominguez-Manzanares , Ana Escribano , Maria Fernandez , William Hornback , Alma Jimenez-Aguado , Eric Tromiczak , Zhipei Wu , Hamideh Zarrinmayeh , Dennis Zimmerman
发明人： Ana Castano Mansanet , Esteban Dominguez-Manzanares , Ana Escribano , Maria Fernandez , William Hornback , Alma Jimenez-Aguado , Eric Tromiczak , Zhipei Wu , Hamideh Zarrinmayeh , Dennis Zimmerman
IPC分类号： A61K31/5377 , A61K31/665 , A61K31/497 , A61K31/506 , A61K31/433 , A61K31/4433 , A61K31/4436 , A61K31/425 , A61K31/453
CPC分类号： C07D307/68 , C07D333/38 , C07D409/10 , C07D417/10
摘要： The present invention relates to thiophene and furan compounds and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression.
摘要翻译： 本发明涉及噻吩和呋喃化合物及其药学上可接受的盐，并且还涉及它们在治疗精神分裂症，与精神分裂症相关的认知缺陷，阿尔茨海默病，阿尔茨海默氏型痴呆，轻度认知障碍或抑郁症中的用途。
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公开(公告)号：US20070142441A1
公开(公告)日：2007-06-21
申请号：US11446840
申请日：2006-06-05
申请人： Ana Castano Mansanet , Frederic Cordier , Esteban Dominguez-Manzanares , Jian Hong , William Hornback , Delu Jiang
发明人： Ana Castano Mansanet , Frederic Cordier , Esteban Dominguez-Manzanares , Jian Hong , William Hornback , Delu Jiang
IPC分类号： A61K31/4412 , A61K31/4152 , A61K31/381 , A61K31/277 , A61K31/195 , A61K31/41
CPC分类号： C07D257/04 , C07C311/08 , C07C323/63 , C07D213/75 , C07D213/76 , C07D231/38 , C07D333/36 , C07D409/10
摘要： The present invention relates to AMPA receptor potentiators of Formula I: formulations comprising them, methods for their use, and intermediates useful for their preparation.
摘要翻译： 本发明涉及式I的AMPA受体增强剂：包含它们的制剂，它们的使用方法和可用于其制备的中间体。
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4.发明授权公开(公告)号：US07625932B2
公开(公告)日：2009-12-01
申请号：US10570985
申请日：2004-08-27
申请人： Pamela Ann Albaugh , Esteban Dominguez-Manzanares , Jian Eric Hong , William Joseph Hornback , Delu Jiang , Paul Leslie Ornstein , Michelle Lee Thompson , Eric George Tromiczak , Zhipei Wu , Hamideh Zarrinmayeh , Dennis Michael Zimmerman , Ana Maria Castano Mansanet , Larry Gene Huffman , William David Miller
发明人： Pamela Ann Albaugh , Esteban Dominguez-Manzanares , Jian Eric Hong , William Joseph Hornback , Delu Jiang , Paul Leslie Ornstein , Michelle Lee Thompson , Eric George Tromiczak , Zhipei Wu , Hamideh Zarrinmayeh , Dennis Michael Zimmerman , Ana Maria Castano Mansanet , Larry Gene Huffman , William David Miller
IPC分类号： A61K31/675 , A61K31/433 , C07D417/02 , C07D413/02
CPC分类号： C07D207/34 , C07D207/36 , C07D231/14 , C07D401/10 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/10 , C07D409/10 , C07D409/12 , C07D413/10 , C07D417/10
摘要： The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.
摘要翻译： 本发明涉及式（I）的吡咯和吡唑化合物及其药学上可接受的盐，并且还涉及它们在治疗精神分裂症，与精神分裂症相关的认知缺陷，阿尔茨海默病，阿尔茨海默氏型痴呆，轻度认知障碍或 萧条。 这些化合物作为谷氨酸受体，特别是AMPA和GluR家族的增效剂。
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公开(公告)号：US20060100237A1
公开(公告)日：2006-05-11
申请号：US11302869
申请日：2005-12-14
申请人： Macklin Arnold , Thomas Bleisch , Ana Castano Mansanet , Esteban Dominguez-Manzanares , Jose Martinez-Perez , Paul Ornstein , Mark Winter
发明人： Macklin Arnold , Thomas Bleisch , Ana Castano Mansanet , Esteban Dominguez-Manzanares , Jose Martinez-Perez , Paul Ornstein , Mark Winter
IPC分类号： A61K31/47 , C07D217/12
CPC分类号： C07D401/12 , C07D217/26 , C07D401/14 , C07D409/14 , C07D417/14
摘要： The present invention provides novel compounds of Formula (I) and Formula (I(a)), or the pharmaceutically acceptable salts thereof; methods for treating neurological disorders and neurodegenerative diseases, particularly pain and migraine, comprising administering a compound of Formula (I) or Formula (I(a)); and processes for preparing compounds of Formula (I) or Formula (I(a)).
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公开(公告)号：US07642361B2
公开(公告)日：2010-01-05
申请号：US10596419
申请日：2005-01-05
申请人： Ana Maria Castano Mansanet , Esteban Dominguez-Manzanares , Ana Maria Escribano , Maria Carmen Fernandez , William Joseph Hornback , Alma Maria Jimenez-Aguado , Eric George Tromiczak , Zhipei Wu , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： Ana Maria Castano Mansanet , Esteban Dominguez-Manzanares , Ana Maria Escribano , Maria Carmen Fernandez , William Joseph Hornback , Alma Maria Jimenez-Aguado , Eric George Tromiczak , Zhipei Wu , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： C07D333/38
CPC分类号： C07D307/68 , C07D333/38 , C07D409/10 , C07D417/10
摘要： The present invention relates to thiophene and furan compounds and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression.
摘要翻译： 本发明涉及噻吩和呋喃化合物及其药学上可接受的盐，并且还涉及它们在治疗精神分裂症，与精神分裂症相关的认知缺陷，阿尔茨海默病，阿尔茨海默氏型痴呆，轻度认知障碍或抑郁症中的用途。
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公开(公告)号：US07393868B2
公开(公告)日：2008-07-01
申请号：US11446840
申请日：2006-06-05
申请人： Ana Maria Castano Mansanet , Frederic Laurent Cordier , Esteban Dominguez-Manzanares , Jian Eric Hong , William Joseph Hornback , Delu Jiang
发明人： Ana Maria Castano Mansanet , Frederic Laurent Cordier , Esteban Dominguez-Manzanares , Jian Eric Hong , William Joseph Hornback , Delu Jiang
IPC分类号： A61K31/381 , A61K31/4155 , A61K31/4418 , C07D213/61 , C07D231/16
CPC分类号： C07D257/04 , C07C311/08 , C07C323/63 , C07D213/75 , C07D213/76 , C07D231/38 , C07D333/36 , C07D409/10
摘要： The present invention relates to AMPA receptor potentiators of Formula I: formulations comprising them, methods for their use, and intermediates useful for their preparation.
摘要翻译： 本发明涉及式I的AMPA受体增强剂：包含它们的制剂，它们的使用方法和可用于其制备的中间体。
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公开(公告)号：US07838543B2
公开(公告)日：2010-11-23
申请号：US11719576
申请日：2005-12-16
申请人： James Peter Beck , Brian David Wakefield , Frederic Laurent Cordier , Esteban Dominguez-Manzanares , Kevin Matthew Gardinier , Peter Michael Greenen , Kenneth Allen Savin
发明人： James Peter Beck , Brian David Wakefield , Frederic Laurent Cordier , Esteban Dominguez-Manzanares , Kevin Matthew Gardinier , Peter Michael Greenen , Kenneth Allen Savin
IPC分类号： A01N43/78 , A61K31/425 , C07D417/00 , C07D277/60
CPC分类号： C07D263/58 , C07D277/68 , C07D277/82 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to a melanin concentrating hormone antagonist compound of formula (I); wherein Ar1, L1, R1, q, X, R2, R3, R4, and R5 are as defined, or a pharmaceutically acceptable salt, solvate, or enantiomer thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.
摘要翻译： 本发明涉及式（I）的黑色素浓缩激素拮抗剂化合物; 其中Ar 1，L 1，R 1，q，X，R 2，R 3，R 4和R 5如所定义，或其药学上可接受的盐，溶剂合物或对映异构体可用于治疗，预防或改善与肥胖症和相关疾病相关的症状 。
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公开(公告)号：US06924294B2
公开(公告)日：2005-08-02
申请号：US10450669
申请日：2001-12-19
申请人： Thomas John Bleisch , Ana Maria Castano Mansanet , Esteban Dominguez-Manzanares , Ana Maria Escribano
发明人： Thomas John Bleisch , Ana Maria Castano Mansanet , Esteban Dominguez-Manzanares , Ana Maria Escribano
IPC分类号： C07D217/26 , C07D401/12 , A61K31/472 , C07D217/16
CPC分类号： C07D401/12 , C07D217/26
摘要： The present invention provides novel compounds of Formula (I), or the pharmaceutically acceptable salts or prodrugs thereof, and methods for treating neurological disorders and neurodegenerative diseases, particularly pain and migraine.
摘要翻译： 本发明提供新的式（I）化合物或其药学上可接受的盐或前药，以及用于治疗神经障碍和神经变性疾病，特别是疼痛和偏头痛的方法。
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公开(公告)号：US08097652B2
公开(公告)日：2012-01-17
申请号：US12517431
申请日：2007-12-06
IPC分类号： A61K31/192 , A61P25/16 , A61P25/24
CPC分类号： C07C311/06
摘要： The present invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其可用于治疗与谷氨酸功能失调相关的病症，例如精神病和神经障碍。
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