公开(公告)号：US20210025884A1

公开(公告)日：2021-01-28

申请号：US17071578

申请日：2020-10-15

Applicant: Panasonic Intellectual Property Management Co., Ltd.

Inventor： TAKASHI KANNO ,  HIROTO YANAGAWA

IPC: G01N33/543 ,  G01N21/64

Abstract: One non-limiting and exemplary embodiment provides a metal microscopic structure capable of detecting a low-concentration analyte with high sensitivity. The metal microscopic structure includes a base member including multiple protrusions arrayed at predetermined intervals, and multiple projections made of a metal film covering the base member and configured to generate surface plasmons upon irradiation with light. A film thickness of the metal film positioned in a bottom portion of a gap between every adjacent two of the multiple projections is greater than a height of the multiple protrusions and is more than or equal to 90% and less than or equal to 100% of a film thickness of the metal film deposited on top portions of the multiple protrusions.

公开(公告)号：US20230398552A1

公开(公告)日：2023-12-14

申请号：US18457404

申请日：2023-08-29

Applicant: Panasonic Intellectual Property Management Co., Ltd.

Inventor： SATOSHI ARIMOTO ,  TAKASHI KANNO ,  RUI HIRAOKA

IPC: B03C5/00 ,  G01N15/14 ,  G01N33/68 ,  B03C5/02 ,  G01N27/447

CPC classification number: B03C5/005 ,  G01N15/1434 ,  G01N33/6854 ,  B03C5/022 ,  G01N27/44721

Abstract: In a detection method, first dielectric particles each capable of being bound to a first target substance and second dielectric particles each capable of being bound to a second target substance are caused to react with a sample that contains a first target substance and a second target substance, the second dielectric particles having a different dielectrophoretic property from the first dielectric particles, a first composite particle to which the first target substance is bound is separated from the other first dielectric particle, and a second composite particle to which the second target substance is bound is separated from the other second dielectric particle by causing dielectrophoresis in the sample after the reaction, and the first target substance contained in the separated first composite particle and the second target substance contained in the second composite particle are each detected.

公开(公告)号：US20210088510A1

公开(公告)日：2021-03-25

申请号：US17111616

申请日：2020-12-04

Applicant: Panasonic Intellectual Property Management Co., Ltd.

Inventor： TAKASHI KANNO

IPC: G01N33/543 ,  G01N33/58 ,  G01N33/84

Abstract: The present disclosure provides a modified particle in which deterioration of a specific binding substance fixed to the surface of the particle is reduced. The modified particle according to the present disclosure contains a particle, a specific binding substance that has a property of specifically binding to an analyte and that has been fixed to the surface of the particle, and an amino sugar molecule fixed to the surface of the particle with an amide bond.

公开(公告)号：US20240027322A1

公开(公告)日：2024-01-25

申请号：US18480536

申请日：2023-10-04

Applicant: Panasonic Intellectual Property Management Co., Ltd.

Inventor： TAKASHI KANNO

IPC: G01N15/14 ,  G01N27/447

CPC classification number: G01N15/1404 ,  G01N15/1456 ,  G01N27/44786 ,  G01N27/44721 ,  G01N2015/1415

Abstract: A detection method includes applying a magnetic field to a sample including a composite particle, an unbound particle, and a first solvent, thereby retaining the composite particle and the unbound particle, each of the composite particle and the unbound particle including a magnetic dielectric particle modified by a substance capable of specifically binding to a target substance, the composite particle being bound to the target substance, the unbound particle being not bound to the target substance; replacing, when a predetermined condition is satisfied, at least part of the first solvent with a second solvent with lower electrical conductivity than the first solvent in a state in which the composite particle and the unbound particle are retained; stopping the application of the magnetic field and applying an electric field, thereby separating the composite particle and the unbound particle by dielectrophoresis; and detecting the separated composite particle, thereby detecting the target substance.

公开(公告)号：US20230020529A1

公开(公告)日：2023-01-19

申请号：US17935929

申请日：2022-09-27

Applicant: Panasonic Intellectual Property Management Co., Ltd.

Inventor： TAKASHI KANNO ,  RUI HIRAOKA ,  SATOSHI ARIMOTO

IPC: B01L3/00 ,  G01N27/447 ,  B03C5/00 ,  G01N33/561

Abstract: A detection method includes forming a complex by binding a target substance and a dielectric particle modified by a single-domain antibody that is bindable to the target substance, separating the complex and an unbound particle in a fluid with dielectrophoresis, the unbound particle being the dielectric particle not forming the complex, and detecting the target substance contained in the separated complex with an imaging element.