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公开(公告)号：US20220018753A1
公开(公告)日：2022-01-20
申请号：US17491585
申请日：2021-10-01
Inventor： SATOSHI ARIMOTO
Abstract: A target substance detection method includes forming a complex by causing a target substance and a dielectric particle to bind to each other, the dielectric particle being modified with a substance (for example, an antibody) having a property of specifically binding to the target substance; subjecting a bound particle and an unbound particle to dielectrophoresis in a liquid, the bound particle being the dielectric particle constituting the complex, the unbound particle being a dielectric particle not constituting the complex; and detecting the target substance in the complex, based on a difference in motion between the bound particle and the unbound particle caused by the dielectrophoresis.
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公开(公告)号：US20230398552A1
公开(公告)日：2023-12-14
申请号：US18457404
申请日：2023-08-29
Inventor： SATOSHI ARIMOTO , TAKASHI KANNO , RUI HIRAOKA
IPC: B03C5/00 , G01N15/14 , G01N33/68 , B03C5/02 , G01N27/447
CPC classification number: B03C5/005 , G01N15/1434 , G01N33/6854 , B03C5/022 , G01N27/44721
Abstract: In a detection method, first dielectric particles each capable of being bound to a first target substance and second dielectric particles each capable of being bound to a second target substance are caused to react with a sample that contains a first target substance and a second target substance, the second dielectric particles having a different dielectrophoretic property from the first dielectric particles, a first composite particle to which the first target substance is bound is separated from the other first dielectric particle, and a second composite particle to which the second target substance is bound is separated from the other second dielectric particle by causing dielectrophoresis in the sample after the reaction, and the first target substance contained in the separated first composite particle and the second target substance contained in the second composite particle are each detected.
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公开(公告)号：US20220018777A1
公开(公告)日：2022-01-20
申请号：US17488399
申请日：2021-09-29
Inventor： SATOSHI ARIMOTO
Abstract: A target substance detection method includes forming a complex by causing a target substance and a dielectric particle to bind to each other, the dielectric particle being modified with a substance having a property of specifically binding to the target substance; separating the complex and an unbound particle from each other in a liquid by dielectrophoresis, the unbound particle being a dielectric particle not constituting the complex; and detecting the target substance included in the separated complex by using an imaging element.
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公开(公告)号：US20230020529A1
公开(公告)日：2023-01-19
申请号：US17935929
申请日：2022-09-27
Inventor： TAKASHI KANNO , RUI HIRAOKA , SATOSHI ARIMOTO
IPC: B01L3/00 , G01N27/447 , B03C5/00 , G01N33/561
Abstract: A detection method includes forming a complex by binding a target substance and a dielectric particle modified by a single-domain antibody that is bindable to the target substance, separating the complex and an unbound particle in a fluid with dielectrophoresis, the unbound particle being the dielectric particle not forming the complex, and detecting the target substance contained in the separated complex with an imaging element.
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公开(公告)号：US20180119209A1
公开(公告)日：2018-05-03
申请号：US15602149
申请日：2017-05-23
Inventor： SATOSHI ARIMOTO
IPC: C12Q1/68
CPC classification number: C12Q1/6825 , C12N15/115 , C12N2310/16 , C12N2310/3517 , C12Q1/68 , C12Q1/6804 , C12Q1/6816 , C12Q2525/205 , G01N33/946 , G01N2458/10 , C12Q2521/319 , C12Q2563/137
Abstract: The present invention provides a cocaine aptamer represented by at least one selected from the group consisting of the following chemical formula (CI) and the following chemical formula (CII), 5′-R-DNA-L-Fc-3′ (CI) 5′-Fc-L-DNA-R-3′ (CII) where R is selected from the group consisting of a hydrocarbon group and the derivative thereof; DNA consists of a gene sequence capable of binding to cocaine; L is absent or an optional linker; and Fc represents a ferrocene group. The above-identified cocaine aptamer is used to detect cocaine with high sensitivity.
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Patent Agency Ranking
公开(公告)号：US20230033118A1
公开(公告)日：2023-02-02
申请号：US17938372
申请日：2022-10-06
Inventor： RUI HIRAOKA , SATOSHI ARIMOTO
Abstract: A counting method includes aggregating particles in a sample by the action of first dielectrophoretic force, dispersing the aggregated particles by the action of second dielectrophoretic force, which is different from the first dielectrophoretic force, capturing a dispersion image including the dispersed particles, and determining the number of particles on the basis of the dispersion image.
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公开(公告)号：US20180112256A1
公开(公告)日：2018-04-26
申请号：US15601060
申请日：2017-05-22
Inventor： SATOSHI ARIMOTO
IPC: C12Q1/68
CPC classification number: C12N15/115 , C12N2310/16 , C12N2310/351 , G01N2458/10
Abstract: The present invention provides a cocaine aptamer represented by the following chemical formula (CI), R-DNA-L-Fc (CI) where R represents R1-PO4—(CH2)n1—; R1 is selected from the group consisting of a hydrocarbon group and the derivative thereof; n1 represents a natural number; DNA consists of a gene sequence capable of binding to cocaine; L is a linker represented by -L1-(CH2)n2-L2-; L1 is absent or an optional linker; L2 is absent or an optional linker; n2 represents a natural number; and Fc represents a ferrocene group. The present invention provides a cocaine aptamer capable of detecting cocaine with high sensitivity.
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公开(公告)号：US20230028960A1
公开(公告)日：2023-01-26
申请号：US17938375
申请日：2022-10-06
Inventor： RUI HIRAOKA , SATOSHI ARIMOTO
Abstract: A counting method includes aggregating particles in a sample by action of first-direction dielectrophoretic force, dispersing the aggregated particles by action of second-direction dielectrophoretic force, which is different from the first-direction dielectrophoretic force, capturing a dispersion image including the dispersed particles, and determining the number of particles on the basis of the dispersion image.
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公开(公告)号：US20180106819A1
公开(公告)日：2018-04-19
申请号：US15601040
申请日：2017-05-22
Inventor： SATOSHI ARIMOTO
IPC: G01N33/94 , C12N15/115
CPC classification number: G01N33/946 , C12N15/115 , C12N2310/16 , C12N2310/3517 , C12Q1/6804 , C12Q2521/319 , C12Q2525/205 , C12Q2563/137
Abstract: The present invention provides a cocaine aptamer represented by the following chemical formula (Cl), R-DNA-L-Fc (Cl) where R is selected from the group consisting of a hydrocarbon group and the derivative thereof; DNA consists of a gene sequence capable of binding to cocaine; L is a linker represented by ((CH2)2—O)n1—PO4—(CH2)n2-L1; L1 is absent or an optional linker; n1 represents a natural number; n2 represents a natural number; and Fc represents a ferrocene group. The cocaine aptamer is capable of detecting cocaine with high sensitivity.
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10.发明申请ELECTROSTATIC ATOMIZER AND METHOD FOR OBTAINING LIQUID SAMPLE FROM GASEOUS SAMPLE USING SAME 有权静电原子和使用其从气相色谱法获得液体样品的方法公开(公告)号：US20160238492A1
公开(公告)日：2016-08-18
申请号：US14740141
申请日：2015-06-15
Inventor： SATOSHI ARIMOTO
IPC: G01N1/22 , G01N33/497 , B05B5/00
CPC classification number: G01N1/2202 , B05B5/0255 , B05B5/0535 , B05B5/16 , G01N1/2273 , G01N33/497 , G01N2001/2244 , G01N2001/2282
Abstract: The present invention provides an electrostatic atomizer comprising: a container having an inlet; an atomization electrode having one end projecting in the container; an opposite electrode provided in the container; a tubular collection electrode provided opposite to the atomization electrode; a mask surrounding an outer periphery of the tubular collection electrode; and a cooling part for cooling the tubular collection electrode. The opposite electrode is provided between the atomization electrode and the tubular collection electrode. The mask is formed of resin. The mask comprises a mask through-hole. The tubular collection electrode is inserted in the mask through-hole. One end of the tubular collection electrode is located in the mask through-hole. The present invention provides a method for efficiently obtaining a liquid sample from a gaseous sample and an electrostatic atomizer suitable for the method.
Abstract translation: 本发明提供一种静电雾化器，包括：具有入口的容器; 雾化电极，其一端突出在容器中; 设置在容器中的相对电极; 与雾化电极相对设置的管状收集电极; 围绕所述管状收集电极的外周的掩模; 以及用于冷却管状收集电极的冷却部件。 相对电极设置在雾化电极和管状收集电极之间。 掩模由树脂形成。 掩模包括掩模通孔。 管状收集电极插入掩模通孔中。 管状收集电极的一端位于掩模通孔中。 本发明提供了一种从气态样品和适用于该方法的静电雾化器有效获得液体样品的方法。
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