公开(公告)号：US5351683A

公开(公告)日：1994-10-04

申请号：US11785

申请日：1993-02-01

申请人： Paolo Chiesi ,  Paolo Ventura ,  Isabella Panza

发明人： Paolo Chiesi ,  Paolo Ventura ,  Isabella Panza

IPC分类号： A61M13/00 ,  A61M11/00 ,  A61M15/00

CPC分类号： A61M11/002 ,  A61M15/0066 ,  A61M2202/064

摘要： An inhaler for the local administration of powdered drugs to the respiratory tract. The inhaler includes a nozzle and a main body which itself defines a storage chamber for the medicinal substance, a dosing mechanism which supplies precisely measured doses of the drug and a dispensing system which pours the dose of the drug delivered into a collecting chamber. A cavity of the nozzle communicates with the collecting chamber through a central channel designed to reduce air flow resistance as much as possible. Lateral holes provided in the body of the inhaler allow for the passage of air from the outside. Upon inhalation, a negative pressure is created in the chamber in which the dose of powder delivered is collected, drawing an air inflow from the outside. The air flow is mixed with the medicinal substance particles and through the central channel, enters the cavity of the nozzle from where it is directly inhaled.

摘要翻译： 一种吸入器，用于向呼吸道局部施用粉末药物。 吸入器包括一个喷嘴和一个主体，它本身限定了一个用于医药物质的储存室，一个定量给料机构，其提供精确测量的药物剂量，以及一个分配系统，其将递送到收集室中的药物的剂量倾倒。 喷嘴的空腔通过设计成尽可能减小气流阻力的中心通道与收集室连通。 设在吸入器主体中的侧向孔允许空气从外部通过。 吸入后，在其中收集粉末的粉末剂量的室中产生负压，从外部吸入空气。 空气流与药物颗粒混合并通过中心通道进入喷嘴的空腔，从那里直接吸入。

公开(公告)号：US5165391A

公开(公告)日：1992-11-24

申请号：US739655

申请日：1991-08-02

申请人： Paolo Chiesi ,  Isabella Panza ,  Paolo Ventura ,  Marco del Corno ,  Mario Varesco

发明人： Paolo Chiesi ,  Isabella Panza ,  Paolo Ventura ,  Marco del Corno ,  Mario Varesco

IPC分类号： A61M11/00 ,  A61M15/00

CPC分类号： A61M15/0086 ,  A61M15/009 ,  A61M2206/16

摘要： A device for mouth-inhaling medicaments dispensed as aerosols by pressurized cans. The device is flat and compact in shape, and includes a seat for housing a can and defines an expansion chamber into which the aerosol dispensed by the can, when operated, penetrates and expands to circulate with a vortex flow which causes the solvent to evaporate and the flow movement to continue for a relatively long time, hence enabling only very small particles of the medicament to be drawn into the bronchial tubes and lungs. There is only minimum aerosol particle deposition on the walls of the oropharingeal cavity, and inhalation can continue after the entry of aerosol into the expansion chamber ceases.

公开(公告)号：US20050034720A1

公开(公告)日：2005-02-17

申请号：US10168546

申请日：2001-01-02

申请人： Gaetano Brambilla ,  Isabella Panza ,  Alessandra Ferraris

发明人： Gaetano Brambilla ,  Isabella Panza ,  Alessandra Ferraris

IPC分类号： A61K9/00 ,  A61M15/00 ,  A61M11/00

CPC分类号： A61M15/0086 ,  A61K9/008 ,  A61M15/009 ,  A61M2206/16

摘要： A device for delivering metered aerosols g an active ingredient in solution in a propellant consisting of a hydrofluoroalkane (HFA), selected from 1,1,1,2-tetrafluoroethane (HFA 134a), 1,1,1,2,3,3,3-heptafluoropropane (HFA 227) or mixtures thereof, a co-solvent such as ethanol and optionally a low-volatility component preferably selected from glycerol, propylene glycol polyethylene glycol, oleic acid and isopropyl myristate, said device comprising a flat body with a seat for housing the can, an inhalation mouthpiece and an expansion chamber shaped to create a vortex flow of the aerosol particles expelled by the actuator, wherein the actuator orifice diameter is in the range between 0.30 and 0.50 mm.

摘要翻译： 一种用于递送计量气溶胶的装置，其是在由选自1,1,1,2-四氟乙烷（HFA 134a），1,1,1,2,3,3（3））中的氢氟烷烃（HFA）组成的推进剂的溶液中的活性成分 ，3-七氟丙烷（HFA 227）或其混合物，共溶剂如乙醇和任选的低挥发性组分，优选选自甘油，丙二醇聚乙二醇，油酸和肉豆蔻酸异丙酯，所述装置包括具有 用于容纳罐的吸入口和膨胀室，其形成为产生由致动器排出的气溶胶颗粒的涡流，其中致动器孔直径在0.30和0.50mm之间的范围内。