摘要:
A device for mouth-inhaling medicaments dispensed as aerosols by pressurized cans. The device is flat and compact in shape, and includes a seat for housing a can and defines an expansion chamber into which the aerosol dispensed by the can, when operated, penetrates and expands to circulate with a vortex flow which causes the solvent to evaporate and the flow movement to continue for a relatively long time, hence enabling only very small particles of the medicament to be drawn into the bronchial tubes and lungs. There is only minimum aerosol particle deposition on the walls of the oropharingeal cavity, and inhalation can continue after the entry of aerosol into the expansion chamber ceases.
摘要:
An inhaler for the local administration of powdered drugs to the respiratory tract. The inhaler includes a nozzle and a main body which itself defines a storage chamber for the medicinal substance, a dosing mechanism which supplies precisely measured doses of the drug and a dispensing system which pours the dose of the drug delivered into a collecting chamber. A cavity of the nozzle communicates with the collecting chamber through a central channel designed to reduce air flow resistance as much as possible. Lateral holes provided in the body of the inhaler allow for the passage of air from the outside. Upon inhalation, a negative pressure is created in the chamber in which the dose of powder delivered is collected, drawing an air inflow from the outside. The air flow is mixed with the medicinal substance particles and through the central channel, enters the cavity of the nozzle from where it is directly inhaled.
摘要:
The invention relates to carrier particles for use in pharmaceutical compositions for the pulmonary administration of medicaments by means of dry powder inhalers. In particular, the invention relates to a novel technological process for obtaining a carrier modified so as to improve the efficiency of redispersion of active particles and hence increase the respirable fraction. After the treatment of the invention, the surface of said modified carrier particles can also be coated with a suitable additive so as to further improve the respirable fraction.
摘要:
A pharmaceutical formulation in the form of a fast dissolving tablet comprising an active ingredient, sodium glycine carbonate and an acid capable of reacting rapidly with sodium glycine carbonate to release carbon dioxide.
摘要:
A pharmaceutical composition in the form of effervescent tablets comprising an active ingredient and an effervescent blend, wherein the effervescent blend comprises an acidic component and sodium glycine carbonate as alkaline components. Preferred acid components are fumaric acid, maleic acid, and their salts. Tablets are prepared in normal thermo-hygrometric conditions and with standard tabletting equipment.
摘要:
The present invention relates to serinamide, glycinamide, alaninamide and phenylalaninamide derivatives of formula (I) wherein R, R', R.sub.1 and R.sub.2 are as defined in the disclosure. The compounds (I) are useful for the treatment of neurological diseases. ##STR1##
摘要:
A process, and variations thereof, for the preparation of 5,6-dihydroxy-2-amino-1,2,3,4-tetrahydronaphthalene derivatives of formula (I), wherein R.sub.1, R.sub.2, R.sub.3 can independently be hydrogen or lower alkyl.
摘要:
Multicomponent inclusion complexes characterized by the presence of an acidic drug, a base and a cyclodextrin are disclosed. Said complexes have a specific solubility in water.
摘要:
A process, and variations thereof, for the preparation of 5,6-dihydroxy-2-amino-1,2,3,4-tetrahydronaphthalene derivatives of formula (I), wherein R.sub.1, R.sub.2, R.sub.3 can independently be hydrogen or lower alkyl.
摘要:
A pharmaceutical composition in the form of effervescent tablets comprising an active ingredient and an effervescent blend, comprising an acidic component and sodium glycine carbonate as alkaline components. Preferred acid components are fumaric acid, maleic acid, and their salts. Tablets are prepared in normal thermohygrometric conditions and with standard tabletting equipment. A pre-granulation process is also disclosed.