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    MODULES, NEW ASSEMBLAGE KITS AND NEW ASSEMBLES FOR THE CONTROLLED RELEASE OF SUBSTANCES
    4.
    发明申请
    MODULES, NEW ASSEMBLAGE KITS AND NEW ASSEMBLES FOR THE CONTROLLED RELEASE OF SUBSTANCES 审中-公开
    用于控制释放物质的模块，新组装工具和新组件

    公开(公告)号：US20100074926A1

    公开(公告)日：2010-03-25

    申请号：US12312831

    申请日：2006-12-05

    申请人： Paolo Colombo ,  Patrizia Santi ,  Ruggero Bettini ,  Orazio Luca Strusi ,  Fabio Sonvico ,  Gaia Colombo

    发明人： Paolo Colombo ,  Patrizia Santi ,  Ruggero Bettini ,  Orazio Luca Strusi ,  Fabio Sonvico ,  Gaia Colombo

    IPC分类号： A61K9/00 ,  A61J3/10

    CPC分类号： A61K9/2072 ,  A61K9/0065

    摘要： A module which is destroyed in the presence of water solution, composed of a compressed powdery mixture, the said powdery mixture comprising a matrix building component, suitable to release an optionally included active substance into a surrounding aqueous liquid, and one or more tabletting aids chosen from the group consisting of lubricants, glidants, and anti-adherent agents, the said module being provided with particular male topological features allowing its connection to a corresponding female module, giving raise to an assembly that can be safely handled on industrial scale, wherein, in the composition of the male module, the percentage ratio between the tabletting aid and the matrix building component is comprised between 1:2.5 and 1:999. The module can be employed to convey pharmaceuticals, nutraceuticals, agrochemicals or other active principles to the intended site of action.

    摘要翻译： 在水溶液存在下被破坏的模块，由压缩的粉末混合物组成，所述粉末混合物包含基质构建组分，其适于将任选包含的活性物质释放到周围的水性液体中，并且选择一种或多种压片助剂 从由润滑剂，助流剂和抗粘附剂组成的组中，所述模块具有特定的男性拓扑特征，允许其连接到相应的阴模块，从而提高可以以工业规模安全地处理的组件，其中， 在阳模组合物中，压片助剂和基质构成成分之间的百分比为1:2.5至1:9999。 该模块可用于将药物，营养品，农用化学品或其他活性成分输送到预期的作用位置。

    Device for Delivery of Active Principles
    5.
    发明申请
    Device for Delivery of Active Principles 审中-公开
    交付活动原则的设备

    公开(公告)号：US20080292684A1

    公开(公告)日：2008-11-27

    申请号：US11658282

    申请日：2005-07-22

    申请人： Paolo Colombo ,  Patrizia Santi ,  Sara Nicoli ,  Cristina Padula ,  Fabio Marra

    发明人： Paolo Colombo ,  Patrizia Santi ,  Sara Nicoli ,  Cristina Padula ,  Fabio Marra

    IPC分类号： A61F13/00

    CPC分类号： A61K9/7053 ,  A61K9/7061

    摘要： A device for the delivery of active principles for dermal and, in particular, transdermal application having the form of a two-layered patch consisting of a first layer having a homogeneous composition and comprising at least one active principle, a water-soluble film-forming agent and a hydrophilic adhesive polymer, and of a second layer joined in a permanent manner to the first and having a water vapour permeability of less than 500 g/m2 in 24 hours.

    摘要翻译： 用于递送用于皮肤的活性成分的装置，特别是经皮施用，其具有由具有均匀组成并包含至少一种活性成分的第一层组成的双层贴剂形式，水溶性成膜剂 试剂和亲水性粘合剂聚合物，以及在永久性方式连接到第一层并在24小时内具有小于500g / m 2的水蒸气渗透性的第二层。

    COMPOSITIONS IN POWDER FORM MADE OF SOFT AGGLOMERATES OF A MICRONIZED DRUG AND OF A TWO-COMPONENTS EXCIPIENT, AND PROCESS FOR THEIR PREPARATION
    9.
    发明申请
    COMPOSITIONS IN POWDER FORM MADE OF SOFT AGGLOMERATES OF A MICRONIZED DRUG AND OF A TWO-COMPONENTS EXCIPIENT, AND PROCESS FOR THEIR PREPARATION 审中-公开
    一种微量药物和两种组分的软组合粉末形式的组合物及其制备方法

    公开(公告)号：US20100233276A1

    公开(公告)日：2010-09-16

    申请号：US12734300

    申请日：2007-10-26

    申请人： Renata Raffin ,  Paolo Colombo ,  Fabio Sonvico ,  Gaia Colombo ,  Alessandra Rossi ,  Francesca Buttini

    发明人： Renata Raffin ,  Paolo Colombo ,  Fabio Sonvico ,  Gaia Colombo ,  Alessandra Rossi ,  Francesca Buttini

    IPC分类号： A61K9/14 ,  A61K9/50 ,  A61K9/58 ,  A61K9/60 ,  A61K9/62 ,  A61K9/64

    CPC分类号： A61K9/1617 ,  A61K9/1623

    摘要： The described agglomeration of drug microparticles blended with excipient microparticles is a technique for the size enlargement of micronized products that could be damaged by granulation or compaction techniques. These agglomerates can be used as oral prompt or delayed-release dosage forms administered as they are or dispersed in a liquid. The composition and quantity of the excipient microparticles resulted to be the crucial factors for the agglomerate quality. Therefore, adjusting the content of surface-active agent between 8-20%, of the excipient microparticles it is possible to agglomerate microparticles of drugs that could not be agglomerated per se. Increasing the surfactant concentration in the spray-dried excipient microparticles or increasing the fraction of these excipient microparticles in the blend, the agglomeration was improved. The spray drying technique concentrates the surface-active agent on the microparticle surface. By tumbling, the surface-active agent present on microparticles excipient surface was spread to fill the inter-particle interstices of drug particles giving rise to more resistant agglomerates. This phenomenon occurred also by vibration; the production in this case was quicker.

    摘要翻译： 与赋形剂微粒混合的药物微粒的所述团聚是用于通过造粒或压实技术损坏的微粉化产品的尺寸增大的技术。 这些附聚物可以作为口服或缓释剂型使用，或者分散在液体中。 赋形剂微粒的组成和数量是聚集质量的关键因素。 因此，调整表面活性剂的含量在8〜20％之间，赋形剂微粒可能聚集本身不能团聚的药物微粒。 增加喷雾干燥的赋形剂微粒中的表面活性剂浓度或增加共混物中这些赋形剂微粒的分数，聚集得到改善。 喷雾干燥技术将表面活性剂浓缩在微粒表面上。 通过翻滚，存在于微粒赋形剂表面上的表面活性剂被扩散以填充药物颗粒的颗粒间隙，从而产生更多的抗凝结物质。 这种现象也是由振动引起的。 在这种情况下的生产更快。