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公开(公告)号：US09114238B2
公开(公告)日：2015-08-25
申请号：US12148180
申请日：2008-04-16
申请人： Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
发明人： Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
CPC分类号： A61M37/0015 , A61K9/0021 , A61K38/29 , A61K38/385 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061 , A61M2202/0007 , A61M2202/07 , A61M2202/30 , A61M2207/00
摘要： In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
摘要翻译： 在本发明的一个方面，通过向模具提供对应于微突起的负极的空腔形成微突起阵列，在模具上方铸造包含生物相容性材料和溶剂的第一溶液，除去溶剂，铸造第二溶液 在第一浇铸溶液顶部，从第二溶液中除去溶剂，并将得到的阵列从模具中脱模。 第一溶液优选含有活性成分。
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公开(公告)号：US20080269685A1
公开(公告)日：2008-10-30
申请号：US12148180
申请日：2008-04-16
申请人： Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
发明人： Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
CPC分类号： A61M37/0015 , A61K9/0021 , A61K38/29 , A61K38/385 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061 , A61M2202/0007 , A61M2202/07 , A61M2202/30 , A61M2207/00
摘要： In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
摘要翻译： 在本发明的一个方面，通过向模具提供对应于微突起的负极的空腔形成微突起阵列，在模具上方铸造包含生物相容性材料和溶剂的第一溶液，除去溶剂，铸造第二溶液 在第一浇铸溶液顶部，从第二溶液中除去溶剂，并将得到的阵列从模具中脱模。 第一溶液优选含有活性成分。
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公开(公告)号：US08911749B2
公开(公告)日：2014-12-16
申请号：US12249795
申请日：2008-10-10
申请人： Esi Ghartey-Tagoe , Janet Wendorf , Steve Williams , Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
发明人： Esi Ghartey-Tagoe , Janet Wendorf , Steve Williams , Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
CPC分类号： A61K39/07 , A61B17/205 , A61K9/0021 , A61K39/00 , A61K2039/54 , A61M37/0015 , Y02A50/388 , Y02A50/39 , Y02A50/401 , Y02A50/464 , Y02A50/466 , Y02A50/484
摘要： A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.
摘要翻译： 提供了一种微突出物阵列，其包括近似平面的基底和多个微突出物，其中阵列包括疫苗和聚合物材料。 阵列可能有多个层。 疫苗可以仅放置在一个层中。 在本发明的另一个实施方案中，提供了一种预防疾病的方法，其包括向患者的皮肤插入包含一层包含该疾病的疫苗和聚合物的微阵列的微阵列阵列。
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公开(公告)号：US20090155330A1
公开(公告)日：2009-06-18
申请号：US12249795
申请日：2008-10-10
申请人： Esi Ghartey-Tagoe , Janet Wendorf , Steve Williams , Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
发明人： Esi Ghartey-Tagoe , Janet Wendorf , Steve Williams , Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andy Klemm , Steven Richard Klemm , Guohua Chen
IPC分类号： A61F2/00 , A61K39/102 , A61K39/05 , A61K39/29 , A61K39/145 , A61K39/205 , A61K39/193 , A61K39/20 , A61K39/09 , A61K39/07
CPC分类号： A61K39/07 , A61B17/205 , A61K9/0021 , A61K39/00 , A61K2039/54 , A61M37/0015 , Y02A50/388 , Y02A50/39 , Y02A50/401 , Y02A50/464 , Y02A50/466 , Y02A50/484
摘要： A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.
摘要翻译： 提供了一种微突出物阵列，其包括近似平面的基底和多个微突出物，其中所述阵列包括疫苗和聚合物材料。 阵列可能有多个层。 疫苗可以仅放置在一个层中。 在本发明的另一个实施方案中，提供了一种预防疾病的方法，其包括向患者的皮肤插入包含一层包含该疾病的疫苗和聚合物的微阵列的微阵列阵列。
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公开(公告)号：US20080183144A1
公开(公告)日：2008-07-31
申请号：US12009954
申请日：2008-01-22
申请人： Joseph C. Trautman , Robert Wade Worsham , Danir F. Bayramov , Danny Lee Bowers , Steven Richard Klemm , Parminder Singh
发明人： Joseph C. Trautman , Robert Wade Worsham , Danir F. Bayramov , Danny Lee Bowers , Steven Richard Klemm , Parminder Singh
IPC分类号： A61M5/158
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： A microneedle applicator is provided which has two roughly concentric portions which may be, for example, a solid disk and an annulus surrounding it. On the skin-facing side of the inner portion of the applicator a microneedle array is located. The outer portion of the applicator is placed against the skin, contacting it at a zone. The microneedle array is then pressed towards the skin.
摘要翻译： 提供了一种微针施加器，其具有两个大致同心的部分，其可以是例如实心盘和围绕它的环。 在施用器的内部的面向皮肤的一侧，定位有微针阵列。 将施用器的外部部分放置在皮肤上，使其在一个区域接触。 然后将微针阵列压向皮肤。
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公开(公告)号：US08821446B2
公开(公告)日：2014-09-02
申请号：US12009954
申请日：2008-01-22
申请人： Joseph C. Trautman , Robert Wade Worsham , Danir F. Bayramov , Danny Lee Bowers , Steven Richard Klemm , Parminder Singh
发明人： Joseph C. Trautman , Robert Wade Worsham , Danir F. Bayramov , Danny Lee Bowers , Steven Richard Klemm , Parminder Singh
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： A microneedle applicator is provided which has two roughly concentric portions which may be, for example, a solid disk and an annulus surrounding it. On the skin-facing side of the inner portion of the applicator a microneedle array is located. The outer portion of the applicator is placed against the skin, contacting it at a zone. The microneedle array is then pressed towards the skin.
摘要翻译： 提供了一种微针施加器，其具有两个大致同心的部分，其可以是例如实心盘和围绕它的环。 在施用器的内部的面向皮肤的一侧，定位有微针阵列。 将施用器的外部部分放置在皮肤上，使其在一个区域接触。 然后将微针阵列压向皮肤。
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