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1.
公开(公告)号:US08389526B2
公开(公告)日:2013-03-05
申请号:US12849642
申请日:2010-08-03
申请人: Pascal Furet , Clive McCarthy , Joseph Schoepfer , Stefan Stutz
发明人: Pascal Furet , Clive McCarthy , Joseph Schoepfer , Stefan Stutz
IPC分类号: A01N43/58 , A61K31/50 , C07D487/00
CPC分类号: C07D487/04
摘要: The invention relates to compounds of formula (I) and salts thereof wherein the substituents are as defined in the specification, the application of a compound of formula (I) in a process for the treatment of the human or animal body, in particular with regard to C-Met tyrosine kinase mediated disease; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner; processes for the preparation of a compound of formula (I).
摘要翻译: 本发明涉及式(I)化合物及其盐,其中取代基如本说明书中所定义,式(I)化合物在治疗人或动物体的方法中的应用,特别是关于 对C-Met酪氨酸激酶介导的疾病; 使用式(I)化合物制备用于治疗这些疾病的药物; 包含式(I)化合物的药物组合物,任选地在组合配偶体存在下; 制备式(I)化合物的方法。
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2.
公开(公告)号:US20110039831A1
公开(公告)日:2011-02-17
申请号:US12849642
申请日:2010-08-03
申请人: Pascal Furet , Clive McCarthy , Joseph Schoepfer , Stefan Stutz
发明人: Pascal Furet , Clive McCarthy , Joseph Schoepfer , Stefan Stutz
IPC分类号: A61K31/5025 , C07D487/04 , A61K31/551 , A61P35/00
CPC分类号: C07D487/04
摘要: The invention relates to compounds of formula (I) and salts thereof wherein the substituents are as defined in the specification, the application of a compound of formula (I) in a process for the treatment of the human or animal body, in particular with regard to C-Met tyrosine kinase mediated disease; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner; processes for the preparation of a compound of formula (I).
摘要翻译: 本发明涉及式(I)化合物及其盐,其中取代基如本说明书中所定义,式(I)化合物在治疗人或动物体的方法中的应用,特别是关于 对C-Met酪氨酸激酶介导的疾病; 使用式(I)化合物制备用于治疗这些疾病的药物; 包含式(I)化合物的药物组合物,任选地在组合配偶体存在下; 制备式(I)化合物的方法。
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公开(公告)号:US20120165310A1
公开(公告)日:2012-06-28
申请号:US13394534
申请日:2010-09-10
申请人: Bei Chen , Robin Alec Fairhurst , Andreas Floersheimer , Pascal Furet , Vito Guagnano , Jiang Songchun , Wenshuo Lu , Thomas H. Marsilje, III , Clive McCarthy , Pierre-Yves Michellys , Frederic Stauffer , Stefan Stutz , Andrea Vaupel
发明人: Bei Chen , Robin Alec Fairhurst , Andreas Floersheimer , Pascal Furet , Vito Guagnano , Jiang Songchun , Wenshuo Lu , Thomas H. Marsilje, III , Clive McCarthy , Pierre-Yves Michellys , Frederic Stauffer , Stefan Stutz , Andrea Vaupel
IPC分类号: A61K31/519 , A61K31/541 , C07D493/08 , A61K31/5377 , A61K31/554 , A61P19/00 , A61K31/5386 , C07D495/08 , A61P35/00 , A61P11/00 , A61P1/16 , C07D487/04 , C07D487/08
CPC分类号: C07D487/04 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2059 , A61K9/4858
摘要: The invention relates to compounds of formula I, wherein the substituents are as defined in the specification; to processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; such compounds as a medicament; such compounds for the treatment of a proliferative disease.
摘要翻译: 本发明涉及式I化合物,其中取代基如说明书中所定义; 制备这些化合物的方法; 包含这些化合物的药物组合物; 诸如药物的化合物; 这种化合物用于治疗增殖性疾病。
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公开(公告)号:US08969341B2
公开(公告)日:2015-03-03
申请号:US14361068
申请日:2012-11-28
申请人: Pascal Furet , Vito Guagnano , Philipp Holzer , Robert Mah , Keiichi Masuya , Achim Schlapbach , Stefan Stutz , Andrea Vaupel
发明人: Pascal Furet , Vito Guagnano , Philipp Holzer , Robert Mah , Keiichi Masuya , Achim Schlapbach , Stefan Stutz , Andrea Vaupel
IPC分类号: A61K31/5377 , A61K31/497 , A61K31/517 , A61K31/519 , A61K31/505 , A61K31/4709 , A61K31/4523 , A61K31/4155 , C07D413/14 , C07D487/14 , C07D239/02 , C07D403/14 , C07D215/00 , C07D211/80 , C07D401/14 , C07D257/02 , C07D487/04 , A61K31/41 , A61K31/4162 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506
CPC分类号: C07D487/04 , A61K31/41 , A61K31/4162 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377
摘要: The invention relates to compounds of formula (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
摘要翻译: 本发明涉及本文所述的式(I)化合物,包含这些化合物的药物制剂,用于治疗由MDM2和/或MDM4的活性介导的疾病或疾病的化合物的用途和用途,以及组合 包括这样的化合物。
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公开(公告)号:US20140275158A1
公开(公告)日:2014-09-18
申请号:US14127159
申请日:2012-06-19
申请人: Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
发明人: Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
IPC分类号: C07D217/24 , C07D405/08 , A61K31/4725 , A61K31/472 , C07D401/08
CPC分类号: C07D217/24 , A61K31/472 , A61K31/4725 , C07D217/04 , C07D401/08 , C07D405/08
摘要: The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.
摘要翻译: 本发明涉及式(I)化合物:如申请中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。
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公开(公告)号:US20140135306A1
公开(公告)日:2014-05-15
申请号:US14127155
申请日:2012-06-19
申请人: Nicole Buschmann , Pascal Furet , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
发明人: Nicole Buschmann , Pascal Furet , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
IPC分类号: C07D409/10 , A61K31/472 , C07D401/04 , A61K31/4725 , C07D401/10 , C07D405/10 , C07D405/14 , C07D217/24 , C07D401/14
CPC分类号: A61K31/4725 , A61K31/472 , C07D217/24 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/08 , C07D451/02 , C07D451/14 , C07D491/08 , C07D493/08
摘要: The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.
摘要翻译: 本发明涉及式(I)化合物:如申请中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。
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公开(公告)号:US09365576B2
公开(公告)日:2016-06-14
申请号:US13900061
申请日:2013-05-22
申请人: Simona Cotesta , Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Robert Mah , Keiichi Masuya , Achim Schlapbach , Stefan Stutz , Andrea Vaupel
发明人: Simona Cotesta , Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Robert Mah , Keiichi Masuya , Achim Schlapbach , Stefan Stutz , Andrea Vaupel
IPC分类号: C07D487/04 , A61K31/407 , A61K31/44 , A61K31/5377 , A61K31/506 , A61K31/41 , A61K31/4439 , A61K45/06
CPC分类号: C07D487/04 , A61K31/407 , A61K31/41 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K45/06
摘要: The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
摘要翻译: 本发明涉及式(I)化合物:如本文所述,包含这些化合物的药物制剂,用于治疗由MDM2和/或MDM4的活性介导的疾病或疾病的这些化合物的用途和方法,以及 包含这些化合物的组合。
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公开(公告)号:US20130317024A1
公开(公告)日:2013-11-28
申请号:US13900061
申请日:2013-05-22
申请人: Simona Cotesta , Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Robert Mah , Keiichi Masuya , Achim Schlapbach , Stefan Stutz , Andrea Vaupel
发明人: Simona Cotesta , Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Robert Mah , Keiichi Masuya , Achim Schlapbach , Stefan Stutz , Andrea Vaupel
IPC分类号: C07D487/04 , A61K31/4439 , A61K45/06 , A61K31/5377 , A61K31/41 , A61K31/407 , A61K31/506
CPC分类号: C07D487/04 , A61K31/407 , A61K31/41 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K45/06
摘要: The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
摘要翻译: 本发明涉及式(I)化合物:如本文所述,包含这些化合物的药物制剂,用于治疗由MDM2和/或MDM4的活性介导的疾病或疾病的这些化合物的用途和方法,以及 包含这些化合物的组合。
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公开(公告)号:US08859586B2
公开(公告)日:2014-10-14
申请号:US14127159
申请日:2012-06-19
申请人: Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
发明人: Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
IPC分类号: C07D217/22 , A61K31/47 , A61K31/4725 , A61K31/472 , C07D405/08 , C07D401/08 , C07D217/24
CPC分类号: C07D217/24 , A61K31/472 , A61K31/4725 , C07D217/04 , C07D401/08 , C07D405/08
摘要: The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.
摘要翻译: 本发明涉及式(I)化合物:如申请中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。
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公开(公告)号:US08440693B2
公开(公告)日:2013-05-14
申请号:US12973474
申请日:2010-12-20
申请人: Joerg Berghausen , Nicole Buschmann , Pascal Furet , François Gessier , Joanna Hergovich Lisztwan , Philipp Holzer , Edgar Jacoby , Joerg Kallen , Keiichi Masuya , Carole Pissot Soldermann , Haixia Ren , Stefan Stutz
发明人: Joerg Berghausen , Nicole Buschmann , Pascal Furet , François Gessier , Joanna Hergovich Lisztwan , Philipp Holzer , Edgar Jacoby , Joerg Kallen , Keiichi Masuya , Carole Pissot Soldermann , Haixia Ren , Stefan Stutz
IPC分类号: A01N37/18 , A61K31/65 , C07D215/00
CPC分类号: C07D239/82 , C07D217/24 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12
摘要: The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N—R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.
摘要翻译: 本发明涉及式(I)的取代的含氮双环杂环,其中Z是CH 2或N-R 4,X,R 1,R 2,R 4,R 6,R 7和n如说明书中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。
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