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1.发明授权Isolated nucleic acid molecule encoding peptides which form complexes with MHC molecules HLA-Cw*1601 and uses thereof 失效编码与MHC分子HLA-Cw * 1601形成复合物的肽的分离的核酸分子及其用途公开(公告)号：US06465184B1
公开(公告)日：2002-10-15
申请号：US09435524
申请日：1999-11-08
申请人： Pascale Bo{haeck over (e)}l , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
发明人： Pascale Bo{haeck over (e)}l , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
IPC分类号： C12Q168
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/70539
摘要： A family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了一系列肿瘤排斥抗原前体和编码它们的核酸分子。 这些肿瘤排斥抗原前体被称为BAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为BAGE编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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2.发明授权Method for treating subjects by using BAGE tumor rejection antigen precursors or tumor rejection antigens 失效通过使用BAGE肿瘤排斥抗原前体或肿瘤排斥抗原治疗受试者的方法公开(公告)号：US06638512B1
公开(公告)日：2003-10-28
申请号：US09382497
申请日：1999-08-25
申请人： Pascale Bo{haeck over (e)}l , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
发明人： Pascale Bo{haeck over (e)}l , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
IPC分类号： A61K3900
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/70539
摘要： A family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了一系列肿瘤排斥抗原前体和编码它们的核酸分子。 这些肿瘤排斥抗原前体被称为BAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为BAGE编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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3.发明授权Isolated nucleic acid molecule encoding peptides which form complexes with MHC molecule HLA-Cw*1601 and uses thereof 失效编码与MHC分子HLA-Cw * 1601形成复合物的肽的分离的核酸分子及其用途
公开(公告)号：US5877017A
公开(公告)日：1999-03-02
申请号：US389360
申请日：1995-02-16
申请人： Pascale Boel , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
发明人： Pascale Boel , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61P35/00 , A61P37/00 , C07H21/02 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/74 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91 , C12N1/15 , C12N1/19
CPC分类号： C07K14/70539 , C07K14/4748 , A61K38/00
摘要： A family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了一系列肿瘤排斥抗原前体和编码它们的核酸分子。 这些肿瘤排斥抗原前体被称为BAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为BAGE编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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4.发明授权Methods for determining complexes of tumor rejection antigens and HLA-Cw*160/molecules 失效确定肿瘤排斥抗原与HLA-Cw * 1601分子复合物的方法
公开(公告)号：US6110694A
公开(公告)日：2000-08-29
申请号：US38328
申请日：1998-03-11
申请人： Pascale Boel , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
发明人： Pascale Boel , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , C07H21/02 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/74 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91 , G01N33/574
CPC分类号： C07K14/4748 , C07K14/70539 , A61K38/00
摘要： A family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了一系列肿瘤排斥抗原前体和编码它们的核酸分子。 这些肿瘤排斥抗原前体被称为BAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为BAGE编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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5.发明授权Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors 失效分离的编码BAGE肿瘤排斥抗原前体的核酸分子
公开(公告)号：US5571711A
公开(公告)日：1996-11-05
申请号：US79110
申请日：1993-06-17
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , C07H21/02 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/74 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91 , C12P19/34 , C12N1/15 , C12N1/19 , C12N5/00 , C12N15/00
CPC分类号： C07K14/4748 , C07K14/70539 , A61K38/00
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为BAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为BAGE编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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6.发明授权Method for diagnosing a disorder characterized by expression of a BAGE tumor rejection antigen precursor 失效用于诊断以BAGE肿瘤排斥抗原前体的表达为特征的病症的方法
公开(公告)号：US6093540A
公开(公告)日：2000-07-25
申请号：US573186
申请日：1995-12-15
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , C07H21/02 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/74 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/4748 , C07K14/70539 , A61K38/00
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为BAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为BAGE编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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7.发明授权METHOD FOR IDENTIFYING INDIVIDUALS SUFFERING FROM A CELLULAR ABNORMALITY SOME OF WHOSE ABNORMAL CELLS PRESENT COMPLEXES OF HLA-CW 1601/MAGE-1 DERIVED PEPTIDES, AND METHODS FOR TREATING SAID INDIVIDUALS 有权鉴定HLA-CW 1601 / MAGE-1衍生肽复合物异常细胞的一些细胞异常的个体识别方法，以及治疗上述个体的方法公开(公告)号：US06680056B1
公开(公告)日：2004-01-20
申请号：US09633994
申请日：2000-08-08
申请人： Pierre van der Bruggen , Jean-Pierre Szikora , Pierre Coulie , Claude Wildmann , Pascale Boël , Thierry Boon-Falleur
发明人： Pierre van der Bruggen , Jean-Pierre Szikora , Pierre Coulie , Claude Wildmann , Pascale Boël , Thierry Boon-Falleur
IPC分类号： A61K3900
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/70539
摘要： Peptides which satisfy the formula of SEQ ID NO: 10 bind to HLA-Cw*1601 molecules, and stimulate proliferation of cytolytic T cells. Examples of such peptides are those set forth in SEQ ID NOS: 4 and 5.
摘要翻译： 满足SEQ ID NO：10的式的肽与HLA-Cw * 1601分子结合，并刺激溶细胞T细胞的增殖。 这些肽的实例是SEQ ID NO：4和5所示的那些。
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8.发明授权
公开(公告)号：US5977300A
公开(公告)日：1999-11-02
申请号：US531864
申请日：1995-09-21
IPC分类号： G01N33/50 , A61K31/00 , A61K35/14 , A61K38/00 , A61K39/00 , A61P35/00 , C07H21/04 , C07K7/06 , C07K14/47 , C07K14/705 , C07K14/74 , C12N1/21 , C12N5/02 , C12N5/06 , C12N5/08 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , C12R1/91 , G01N33/569 , A61K38/08
CPC分类号： C12Q1/6881 , C07K14/4748 , C07K14/70539 , C12Q1/6886 , G01N33/56977 , A61K39/00 , C12Q2600/112
摘要： Tumor rejection antigens presented by HLA-B44 molecules are described. These peptides are useful in diagnostic and therapeutic methodologies. The tumor rejection antigens are not derived from tyrosinase, which has previously been identified as a tumor rejection antigen precursor processed to an antigen presented by HLA-B44.
摘要翻译： 描述了由HLA-B44分子呈递的肿瘤排斥抗原。 这些肽可用于诊断和治疗方法。 肿瘤排斥抗原不是源自酪氨酸酶，酪氨酸酶先前被鉴定为被HLA-B44呈递的抗原加工的肿瘤排斥抗原前体。
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公开(公告)号：US5585461A
公开(公告)日：1996-12-17
申请号：US217186
申请日：1994-03-24
CPC分类号： C07K14/4748 , A61K38/00 , Y10S530/828 , Y10S530/865
摘要： Tumor rejection antigens derived from tumor rejection precursor MAGE-3 have been identified. These "TRAS" bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the production of cytolytic T cell clones which lyse the presenting cells. The peptides and complexes may be used diagnostically, therapeutically, and as immunogens for the production of antibodies, or as targets for the generation of cytolytic T cell clones.
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公开(公告)号：US06171806B2
公开(公告)日：2001-01-09
申请号：US09266294
申请日：1999-03-11
IPC分类号： G01N33574
CPC分类号： C12Q1/6881 , A61K39/00 , C07K14/4748 , C07K14/70539 , C12Q1/6886 , C12Q2600/112 , G01N33/56977
摘要： Tumor rejection antigens presented by HLA-B44 molecules are described. These peptides are useful in diagnostic and therapeutic methodologies. The tumor rejection antigens are not derived from tyrosinase, which has previously been identified as a tumor rejection antigen precursor processed to an antigen presented by HLA-B44.
摘要翻译： 描述了由HLA-B44分子呈递的肿瘤排斥抗原。 这些肽可用于诊断和治疗方法。 肿瘤排斥抗原不是源自酪氨酸酶，酪氨酸酶先前被鉴定为被HLA-B44呈递的抗原加工的肿瘤排斥抗原前体。
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