公开(公告)号：US06648880B2

公开(公告)日：2003-11-18

申请号：US10077183

申请日：2002-02-15

申请人： Patrick Chauvet ,  Daniel Nahon

发明人： Patrick Chauvet ,  Daniel Nahon

IPC分类号： A61B1818

CPC分类号： A61B18/02 ,  A61B2018/0212 ,  A61B2018/0262

摘要： A method is disclosed for treating brain tissue with cryotreatment. A surgical tool, such as a catheter is disposed proximate to a target region of brain tissue. The tool or catheter provided includes a cryotreatment element. The cryotreatment element may be a cryochamber for enclosing the flow of a fluid refrigerant therein. The cryotreatment element is disposed at the situs of brain tissue to be treated, either through endovascular insertion, or via an opening in the cranium. A refrigerant flow within the cryochamber creates endothermic cooling with respect to the surrounding brain tissue, inducing hypothermia and forming iceballs proximate said tissue. The cooling may be reversible and non-permanent, or may be permanent leading to cell death, necrosis, apoptosis and/or surgical excision or ablation of tissue. Mapping using conventional techniques may be used to measure and assess brain function before and after cryotreatment, and cryotreatment itself may be integrally and progressively used to map brain function and treat tissue.

公开(公告)号：US07912554B2

公开(公告)日：2011-03-22

申请号：US11119368

申请日：2005-04-29

申请人： Leonilda Capuano ,  Daniel Nahon ,  Michael Urick ,  Willard W. Hennemann ,  Patrick Chauvet ,  Claudia Lückge

发明人： Leonilda Capuano ,  Daniel Nahon ,  Michael Urick ,  Willard W. Hennemann ,  Patrick Chauvet ,  Claudia Lückge

IPC分类号： A61F2/00

CPC分类号： A61B18/02 ,  A61B18/22 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2018/00095 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61N5/045 ,  A61N5/0601

摘要： A method is disclosed for treating an aneurysm or vascular defect by cooling a target tissue region of the aneurysm or vascular defect to a temperature below body temperature for a preselected time period. The method entails thickening, strengthening, or increasing the density of a blood vessel wall by cooling the blood vessel wall with a cryogenically cooled device. The method also includes irradiating the inner wall of a blood vessel around an aneurysm or vascular defect with various forms of energy to delay or halt aneurysm or vascular defect formation. An energy-emitting element is disposed on the distal end portion of a catheter device to be disposed proximate the aneurysm. Various forms of energy, including visible light energy, laser light energy, ultrasound, microwave and radiofrequency sources may be used to irradiate and treat the aneurysm. In addition, the method may include irradiating a tissue site concomitantly with other treatments, including the delivery of vaso-occlusive compounds, mechanical intravascular devices, or an endovascular graft to the target tissue region.

摘要翻译： 公开了一种用于通过将动脉瘤或血管缺陷的靶组织区域冷却到低于体温的温度预处理时间段来治疗动脉瘤或血管缺陷的方法。 该方法通过用低温冷却装置冷却血管壁来增加，增强或增加血管壁的密度。 该方法还包括以各种形式的能量照射动脉瘤或血管缺损周围的血管内壁，以延迟或停止动脉瘤或血管缺损形成。 能量发射元件设置在导管装置的远端部分上以靠近动脉瘤设置。 可以使用包括可见光能量，激光能量，超声波，微波和射频源在内的各种形式的能量照射和治疗动脉瘤。 此外，该方法可以包括与其它治疗伴随地照射组织部位，包括将血管闭塞化合物，机械血管内装置或血管内移植物递送至靶组织区域。

公开(公告)号：US20050222649A1

公开(公告)日：2005-10-06

申请号：US11119368

申请日：2005-04-29

申请人： Leonilda Capuano ,  Daniel Nahon ,  Michael Urick ,  Willard Hennemann ,  Patrick Chauvet ,  Claudia Luckge

发明人： Leonilda Capuano ,  Daniel Nahon ,  Michael Urick ,  Willard Hennemann ,  Patrick Chauvet ,  Claudia Luckge

IPC分类号： A61B17/22 ,  A61B18/00 ,  A61B18/02 ,  A61B18/22 ,  A61F7/00 ,  A61F7/12 ,  A61N5/06

CPC分类号： A61B18/02 ,  A61B18/22 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2018/00095 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61N5/045 ,  A61N5/0601

摘要： A method is disclosed for treating an aneurysm or vascular defect by cooling a target tissue region of the aneurysm or vascular defect to a temperature below body temperature for a preselected time period. The method entails thickening, strengthening, or increasing the density of a blood vessel wall by cooling the blood vessel wall with a cryogenically cooled device. The method also includes irradiating the inner wall of a blood vessel around an aneurysm or vascular defect with various forms of energy to delay or halt aneurysm or vascular defect formation. An energy-emitting element is disposed on the distal end portion of a catheter device to be disposed proximate the aneurysm. Various forms of energy, including visible light energy, laser light energy, ultrasound, microwave and radiofrequency sources may be used to irradiate and treat the aneurysm. In addition, the method may include irradiating a tissue site concomitantly with other treatments, including the delivery of vaso-occlusive compounds, mechanical intravascular devices, or an endovascular graft to the target tissue region.

摘要翻译： 公开了一种用于通过将动脉瘤或血管缺陷的靶组织区域冷却到低于体温的温度预处理时间段来治疗动脉瘤或血管缺陷的方法。 该方法通过用低温冷却装置冷却血管壁来增加，增强或增加血管壁的密度。 该方法还包括以各种形式的能量照射动脉瘤或血管缺损周围的血管内壁，以延迟或停止动脉瘤或血管缺损形成。 能量发射元件设置在导管装置的远端部分上以靠近动脉瘤设置。 可以使用包括可见光能量，激光能量，超声波，微波和射频源在内的各种形式的能量照射和治疗动脉瘤。 此外，该方法可以包括与其它治疗伴随地照射组织部位，包括将血管闭塞化合物，机械血管内装置或血管内移植物递送至靶组织区域。

公开(公告)号：US06736809B2

公开(公告)日：2004-05-18

申请号：US09964264

申请日：2001-09-26

申请人： Leonilda Capuano ,  Daniel Nahon ,  Michael Urick ,  Willard W. Hennemann ,  Patrick Chauvet

发明人： Leonilda Capuano ,  Daniel Nahon ,  Michael Urick ,  Willard W. Hennemann ,  Patrick Chauvet

IPC分类号： A61B1818

CPC分类号： A61B18/02 ,  A61B2017/22051 ,  A61B2018/00095 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61N5/045 ,  A61N5/0601

摘要： A method is disclosed for treating an aneurysm by cooling a target tissue region of the aneurysm to a temperature below temperature for a preselected time period. The method entails thickening, strengthening, or increasing the density of a blood vessel wall by cooling the blood vessel wall with a cryogenically cooled device. In particular, a device having a heat conductive cooling chamber is disposed proximate to the aneurysm site; and a cryogenic fluid coolant is directed to flow inside the chamber to create endothermic cooling relative to the aneurysm. The method also promotes the growth of collagen and elastin in vascular tissue. Tissue cooling temperatures range from +20 to −20 degrees Celsius. The duration of treatment by application of cooling ranges from 15 seconds to up to 20 minutes or more. The method includes treating the aneurysm both from inside and outside the blood vessel wall forming the aneurysm.

摘要翻译： 公开了一种用于通过将动脉瘤的靶组织区域冷却到低于温度的预选时间段来治疗动脉瘤的方法。 该方法通过用低温冷却装置冷却血管壁来增加，增强或增加血管壁的密度。 特别地，具有导热冷却室的装置设置在动脉瘤部位附近; 并且低温流体冷却剂被引导以在腔室内流动以产生相对于动脉瘤的吸热冷却。 该方法还促进血管组织中胶原和弹性蛋白的生长。 组织冷却温度范围为+20至-20摄氏度。 通过应用冷却治疗的持续时间为15秒至20分钟以上。 该方法包括从形成动脉瘤的血管壁的内部和外部处理动脉瘤。

公开(公告)号：US06369127B1

公开(公告)日：2002-04-09

申请号：US09509068

申请日：2000-04-26

申请人： Daniel Bourgeois ,  Patrick Chauvet

发明人： Daniel Bourgeois ,  Patrick Chauvet

IPC分类号： A61K610

CPC分类号： A61K6/10

摘要： A dispersion for making impression which are capable of gradually releasing antiseptic agent to the surface. The dispersion includes a silicone, a hydrophobic antiseptic agent which is incorporated into the silicone, with the concentration of hydrophobic agent in the dispersion being in the range of about 0.1% to 1% by weight of the total weight of the dispersion. The hydrophobic antiseptic agent is a mixture which includes a chelating agent, a phospholipid membrane attacking agent, and either a virus nucleocapsid attacking agent or a bacteria receptor site attacking agent.

摘要翻译： 用于制造能够逐渐将防腐剂释放到表面的印象的分散体。 分散体包括硅氧烷，掺入硅氧烷中的疏水性防腐剂，疏水剂在分散体中的浓度在分散体总重量的约0.1％至1％的范围内。 疏水性防腐剂是包含螯合剂，磷脂膜攻击剂，病毒核衣壳攻击剂或细菌受体部位攻击剂的混合物。