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公开(公告)号：US08808754B2
公开(公告)日：2014-08-19
申请号：US11477307
申请日：2006-06-29
摘要： A method of treatment of a wound, said method comprising the step of injecting an effective amount of an oxygen-containing fluid into said wound at a location below a surface of said wound, said step of injecting being carried out through a conduit having one or more outlets for said fluid, wherein substantially all of said outlets are positioned below the surface of the wound during said step of injecting. Injection of oxygen directly into the wound tissue below the wound surface provides enhanced wound healing.
摘要翻译： 一种治疗伤口的方法，所述方法包括在所述伤口表面下方的位置将有效量的含氧流体注入所述伤口的步骤，所述注射步骤通过具有一个或多个 用于所述流体的更多出口，其中在所述注入步骤期间，基本上所有所述出口位于伤口表面下方。 将注射氧气直接注入伤口表面下面的伤口组织提供增强的伤口愈合。
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公开(公告)号：US07361634B2
公开(公告)日：2008-04-22
申请号：US10554375
申请日：2004-04-27
CPC分类号： A61L15/44 , A61K38/08 , A61K38/10 , A61L15/24 , A61L15/32 , A61L2300/402 , A61L2300/404 , A61L2300/434 , A61L2300/602 , A61L2300/604 , C08L33/26
摘要： The invention provides a wound dressing comprising a therapeutic agent and a matrix comprising polymers joined by cross-linkages which cross-linkages comprise oligopeptidic sequences which are cleavable by a kallikrein associated with wound fluid such that the rate of release of the therapeutic agent increases in the presence of elevated kallikrein levels.
摘要翻译： 本发明提供了包含治疗剂和包含通过交联连接的聚合物的基质的伤口敷料，所述交联包含可与受伤液相关的激肽释放酶可切割的寡肽序列，使得治疗剂的释放速率在 存在升高的激肽释放酶水平。
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3.发明申请Debridement Method Using Topical Nitric Oxide Donor Devices and Compositions 有权使用局部一氧化氮供体装置和组合物的清创方法公开(公告)号：US20110033437A1
公开(公告)日：2011-02-10
申请号：US12087837
申请日：2007-01-17
CPC分类号： A61K33/00 , A61K9/0014 , A61K9/7069 , A61K45/06 , A61K47/10 , A61K47/34 , A61L15/44 , A61L26/0066 , A61L2300/114
摘要： The present invention relates to methods for removal of dead tissue from wounds or skin using topical nitric oxide donor devices and/or compositions. In one embodiment, the present invention relates to a transdermal patch device that is designed to deliver nitric oxide. In another embodiment, the present invention relates to one or more devices and/or compositions that are designed to deliver nitric oxide and optionally one or more other compounds, where such devices/compositions include, without limitation, bandages, layered bandages, adhesive bandages, transdermal patches, creams, ointments, or a any combination of two or more thereof.
摘要翻译： 本发明涉及使用局部一氧化氮供体装置和/或组合物从伤口或皮肤去除死组织的方法。 在一个实施方案中，本发明涉及被设计成输送一氧化氮的透皮贴剂装置。 在另一个实施方案中，本发明涉及被设计成递送一氧化氮和任选的一种或多种其它化合物的一种或多种装置和/或组合物，其中这种装置/组合物包括但不限于绷带，分层绷带，粘合绷带， 透皮贴剂，霜剂，软膏剂或其两种或多种的任何组合。
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公开(公告)号：US20080166397A1
公开(公告)日：2008-07-10
申请号：US12041955
申请日：2008-03-04
IPC分类号： A61L15/00
CPC分类号： A61L15/44 , A61K38/08 , A61K38/10 , A61L15/24 , A61L15/32 , A61L2300/402 , A61L2300/404 , A61L2300/434 , A61L2300/602 , A61L2300/604 , C08L33/26
摘要： The invention provides a wound dressing comprising a therapeutic agent and a matrix comprising polymers joined by cross-linkages which cross-linkages comprise oligopeptidic sequences which are cleavable by a kallikrein associated with wound fluid such that the rate of release of the therapeutic agent increases in the presence of elevated kallikrein levels.
摘要翻译： 本发明提供了包含治疗剂和包含通过交联连接的聚合物的基质的伤口敷料，所述交联包含可与受伤液相关的激肽释放酶可切割的寡肽序列，使得治疗剂的释放速率在 存在升高的激肽释放酶水平。
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公开(公告)号：US08067370B2
公开(公告)日：2011-11-29
申请号：US12041955
申请日：2008-03-04
CPC分类号： A61L15/44 , A61K38/08 , A61K38/10 , A61L15/24 , A61L15/32 , A61L2300/402 , A61L2300/404 , A61L2300/434 , A61L2300/602 , A61L2300/604 , C08L33/26
摘要： Disclosed is a wound dressing comprising a therapeutic agent and a matrix comprising polymers joined by cross-linkages, wherein the cross-linkages comprise oligopeptidic sequences which are cleavable by a kallikrein associated with wound fluid such that the rate of release of the therapeutic agent increases in the presence of elevated kallikrein levels.
摘要翻译： 公开了包含治疗剂和包含通过交联连接的聚合物的基质的伤口敷料，其中所述交联包含可由与伤口流体相关的激肽释放酶切割的寡肽序列，使得治疗剂的释放速率增加 存在升高的激肽释放酶水平。
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公开(公告)号：US20080003299A1
公开(公告)日：2008-01-03
申请号：US11477307
申请日：2006-06-29
IPC分类号： A61K33/00
摘要： A method of treatment of a wound, said method comprising the step of injecting an effective amount of an oxygen-containing fluid into said wound at a location below a surface of said wound, said step of injecting being carried out through a conduit having one or more outlets for said fluid, wherein substantially all of said outlets are positioned below the surface of the wound during said step of injecting. Injection of oxygen directly into the wound tissue below the wound surface provides enhanced wound healing.
摘要翻译： 一种治疗伤口的方法，所述方法包括在所述伤口表面下方的位置将有效量的含氧流体注入所述伤口的步骤，所述注射步骤通过具有一个或多个 用于所述流体的更多出口，其中在所述注入步骤期间，基本上所有所述出口位于伤口表面下方。 将注射氧气直接注入伤口表面下面的伤口组织提供增强的伤口愈合。
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